Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 1164011..1164594 Replicon chromosome
Accession NZ_CP086259
Organism Escherichia coli strain SCPM-O-B-9427

Toxin (Protein)


Gene name mazF Uniprot ID U9XFN8
Locus tag LMH79_RS05655 Protein ID WP_000254745.1
Coordinates 1164259..1164594 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID S1P3W5
Locus tag LMH79_RS05650 Protein ID WP_000581937.1
Coordinates 1164011..1164259 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LMH79_RS05640 (1160350) 1160350..1161651 + 1302 WP_000046785.1 23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD -
LMH79_RS05645 (1161699) 1161699..1163933 + 2235 WP_000226815.1 GTP pyrophosphokinase -
LMH79_RS05650 (1164011) 1164011..1164259 + 249 WP_000581937.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
LMH79_RS05655 (1164259) 1164259..1164594 + 336 WP_000254745.1 endoribonuclease MazF Toxin
LMH79_RS05660 (1164665) 1164665..1165456 + 792 WP_001071648.1 nucleoside triphosphate pyrophosphohydrolase -
LMH79_RS05665 (1165684) 1165684..1167321 + 1638 WP_137583076.1 CTP synthase (glutamine hydrolyzing) -
LMH79_RS05670 (1167409) 1167409..1168707 + 1299 WP_000036723.1 phosphopyruvate hydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-109)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12158.08 Da        Isoelectric Point: 8.4777

>T222855 WP_000254745.1 NZ_CP086259:1164259-1164594 [Escherichia coli]
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPYTTQSKGYPFEVVLSGQERDGVALADQVKS
IAWRARGATKKGTVAPEELQLIKAKINVLIG

Download         Length: 336 bp

>T222855 NZ_CP118147:118275-119153 [Pseudomonas chlororaphis]
ATGTTGCCAGGCCTCTCTCAACCCGTATCGACGGCGGACCTCCAGGCCCGACTGACCCGGGACTTTGCCCAGCGCCAGGT
GACCGTGGCCGGCGGCCGGCAGGCCCTGCGCGAATGCGGCGCGGGCCCGGCGATCGTGCTGCTGCACGGCATCGGTTCCG
GGGCGGCGTCCTGGCTGCAGGTGGCGCAACAACTGGCGCCCCAGGCCCGGGTCATCGCCTGGGACGCGCCCGGCTACGGC
GATTCCAGCCCCCTGGAATCCCCCGCGCCCAAGGCCGAGCACTACGCCGCCCGCCTGGTGCAGATGCTCGATGCCCTGGA
CGTCGAGGAATGCGTGCTGGTGGGGCATTCCCTCGGCGCGCTGCCGGCCCTGGCCTTCGCTCGTAGTTCACAGGCGAGCC
GGGTGAGTCGCCTGGTACTGATCAGCCCGGCCCGGGGTTATGGCGCGCCGGAACGCGGCGAGCAGCGCCAGCAGGTGCGC
CGCCAGCGCCTGGAGAACCTGGAGCATCTGGGGATCACCGGCCTGGCCGAGCAACGCAGCACCCACATGCTCTCGCCCAA
CGCCGCGCCACAGGCCCTGGCCTGGGTGCGCTGGAACATGGCGCGGCTCAACCCCGCGGGTTATCGCCAGGCCATCGAGC
TGCTGTGCGGCGGCGACCTGCTGCGCCACGGCCAGCCCGGCATGCCCTGCGAAGTGCATTGCGGCGAGGCCGACCGCATC
ACCCCGGCCGAGACCTGCCTGACCCTGGCCAAGGCGCTGGGCGCCAGCTTCAACCTGATCGCCGACGCGGGCCATGCCAG
CCCCATCGAACAACCGCTGGTGGTCGCGGGCCGCCTGGCCTTTGCCATCAAAGAATCCCTGACAGGTAGAACCCTATGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9355.74 Da        Isoelectric Point: 4.4665

>AT222855 WP_000581937.1 NZ_CP086259:1164011-1164259 [Escherichia coli]
MIHSSVKRWGNSPAVRIPATLMQALNLNIDDEVKIDLVDGKLIIEPVRKEPVFTLAELVNDITPENLHENIDWGEPKDKE
VW

Download         Length: 249 bp

>AT222855 NZ_CP118147:119150-119983 [Pseudomonas chlororaphis]
ATGAACGACTCCGATCCGCTGAAGGACGCTCAGGACAAATACATAGTGCCGGGCCTGGAGCGTGGCCTGTTGCTGCTCTG
CGAGTTCAGCCGGCGCAACCGCACCCTGACCGCGCCGGAACTGGCCCGCCGCCTGGCCCTGCCGCGCTCGACCATCTTTC
GCCTGCTCACCACCCTGGAAACCATGGGTTTCGTCACCCGCAGCGGCAACGAATACCGCCTCGGCATGTCGGTGCTGCGC
CTGGGCTTCGAATACCTGGCGTCGCTGGAGCTGACCGAGCTCGGCCAGCCGCTGCTGGCGCGCCTGTGCGACCGCCTCAA
CTACCCGAGCAACCTGGTGGTGCGCGACGGCCGCTCGATCGTCTACGTGGCCAAGGTCTCGCCGCCCTCGGTGTTCTCCA
ACGCGGTCAACGTCGGCACCCGCCTGCCGGCCCACGCCACGGTGCTGGGGCGCATCCTCCTGGAAGACCTGTCCCTGGCC
GAACTGCGCGAGCTGTACCCCGAAGAGCATCTGGAGCAGTACTCCCACAGCACGCCGAAAACCGTGCTGGAGCTGTTCGA
CATGGTCCAGGCCGACCGTCAGCGCGGCTTTATCAGCGGCGAAGGTTTCTTCGAATCGGCGATCTCCACGGTGGCCGCGC
CAGTGCGCGACCAGAGCGGGCGCATCGCCGCGGCCCTGGGCGTGACCATCCCCACCACGCAGATCGGCCACGTCAATTTC
GAGGAACTGCTGTCGCAGGTCCGCCGTAGCGCCGACGAGCTGTCACGCCTGCTCAACTACAACGGCGTGGCCCACGACGG
GCAACAGCGCGTGACCGCCTTGATGAGGGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XYM3

Antitoxin

Source ID Structure
PDB 1UB4
PDB 5CQX
PDB 5CQY
PDB 1MVF
PDB 2MRN
PDB 2MRU
AlphaFold DB A0A7U9LMB4

References