Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 823290..823935 Replicon chromosome
Accession NZ_CP086257
Organism Providencia rettgeri strain KM4

Toxin (Protein)


Gene name Hha Uniprot ID B6XA97
Locus tag LL668_RS03575 Protein ID WP_004905417.1
Coordinates 823290..823493 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A6G6PGA8
Locus tag LL668_RS03580 Protein ID WP_004914480.1
Coordinates 823567..823935 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LL668_RS03550 (LL668_03555) 819387..819725 + 339 WP_004905421.1 P-II family nitrogen regulator -
LL668_RS03555 (LL668_03560) 819775..821022 + 1248 WP_228367686.1 ammonium transporter AmtB -
LL668_RS03560 (LL668_03565) 821161..822030 - 870 WP_123382490.1 acyl-CoA thioesterase II -
LL668_RS03565 (LL668_03570) 822270..822728 + 459 WP_004914482.1 YbaY family lipoprotein -
LL668_RS03575 (LL668_03580) 823290..823493 - 204 WP_004905417.1 HHA domain-containing protein Toxin
LL668_RS03580 (LL668_03585) 823567..823935 - 369 WP_004914480.1 Hha toxicity modulator TomB Antitoxin
LL668_RS03585 (LL668_03590) 824458..825828 - 1371 WP_117162849.1 murein transglycosylase D -
LL668_RS03590 (LL668_03595) 825910..826665 - 756 WP_117162848.1 hydroxyacylglutathione hydrolase -
LL668_RS03595 (LL668_03600) 826706..827440 + 735 WP_004914475.1 methyltransferase domain-containing protein -
LL668_RS03600 (LL668_03605) 827437..827907 - 471 WP_228367440.1 ribonuclease HI -
LL668_RS03605 (LL668_03610) 827962..828723 + 762 WP_196718550.1 DNA polymerase III subunit epsilon -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8061.34 Da        Isoelectric Point: 6.9770

>T222845 WP_004905417.1 NZ_CP086257:c823493-823290 [Providencia rettgeri]
MTKSDYLMRLRKCTTIETLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPASVWKFVR

Download         Length: 204 bp

>T222845 NZ_CP118145:c2552245-2551952 [Pseudomonas chlororaphis]
ATGGATTACGAGATCCTGCAGACGACCGTCTTTGCCCAATGGCACACCACACTACGGGACCTGCGCGCCAGGATAGCGAT
CGCTCGGCGTATCGAGCGGGCTTCGGCGGGCAACCTGGGCGACGTGAAAAACCTCGGCGGCGGCCTCTCGGAAATGCGCG
TGAATACAGGCGCCGGCTACCGCCTCTATTTCACGGTGCGCGGCCACACCCTCATCGTCCTGCTGCTGGGCGGCGACAAG
TCCACCCAGCCTGCCGATATCTGCCAGGCCCGTTCCCTGGCCAAGGAGTTCTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14106.06 Da        Isoelectric Point: 4.3849

>AT222845 WP_004914480.1 NZ_CP086257:c823935-823567 [Providencia rettgeri]
MDEYSPKRHDIAELKYLCNSLNRDAILSLQKTNTHWINDLSSPQSAALNELIEHIAAFVWRFKIKYPKENLVISLIEEYL
DETYDLFGSPVITLSEIIDWEAMNQSLVTVLDDDLKCLTSKT

Download         Length: 369 bp

>AT222845 NZ_CP118145:c2551950-2551660 [Pseudomonas chlororaphis]
ATGTCCGACACCCTGCTTCCCTTCGACATCGCCGCCCTGCTCGACAGCGACCAGGCGATCAGCGAATACCTGTCCCAGGT
CCTGGCCGATGGCGATACCGATGAACTGATCCGCGCCCTGGGCCATGTCGCCAGGGCGCGGGGCATGACGCAGATTGCCA
AGGCCACCGGCCAGGGCCGGGCCAGCCTCTACAAGGCTTTTGCCCCGGGTGCCAAGCCGCGTTTCGATACCGTAGTCAAG
GTCATGCGCGCGCTGGGCCTGCAGCTGTGCACCACCGTGTCCCGCGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A291E6Q2

Antitoxin

Source ID Structure
AlphaFold DB A0A6G6PGA8

References