Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1688524..1689182 Replicon chromosome
Accession NZ_CP086253
Organism Pectobacterium aquaticum strain A212-S19-A16

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag DMB82_RS07895 Protein ID WP_116162549.1
Coordinates 1688754..1689182 (+) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag DMB82_RS07890 Protein ID WP_116162551.1
Coordinates 1688524..1688754 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DMB82_RS07850 (DMB82_0007890) 1684226..1684591 + 366 WP_116162567.1 hypothetical protein -
DMB82_RS07855 (DMB82_0007895) 1684634..1685041 + 408 WP_116162565.1 hypothetical protein -
DMB82_RS07860 (DMB82_0007900) 1685074..1685286 + 213 WP_116162563.1 hypothetical protein -
DMB82_RS07865 (DMB82_0007905) 1685368..1686189 + 822 WP_116162561.1 DUF932 domain-containing protein -
DMB82_RS07870 (DMB82_0007910) 1686242..1686715 + 474 WP_116162559.1 DNA repair protein RadC -
DMB82_RS07875 (DMB82_0007915) 1686755..1687090 + 336 WP_116162557.1 type IV toxin-antitoxin system YeeU family antitoxin -
DMB82_RS07880 (DMB82_0007920) 1687160..1687480 + 321 WP_116162555.1 TA system toxin CbtA family protein -
DMB82_RS07885 (DMB82_0007925) 1687596..1688429 + 834 WP_116162553.1 DUF4942 domain-containing protein -
DMB82_RS07890 (DMB82_0007930) 1688524..1688754 + 231 WP_116162551.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
DMB82_RS07895 (DMB82_0007935) 1688754..1689182 + 429 WP_116162549.1 tRNA(fMet)-specific endonuclease VapC Toxin
DMB82_RS07900 (DMB82_0007940) 1689493..1689690 - 198 WP_226888919.1 hypothetical protein -
DMB82_RS07905 (DMB82_0007945) 1689894..1690181 - 288 WP_102118418.1 HigA family addiction module antitoxin -
DMB82_RS07910 (DMB82_0007950) 1690181..1690459 - 279 WP_102118419.1 type II toxin-antitoxin system RelE/ParE family toxin -
DMB82_RS07915 (DMB82_0007955) 1690589..1690969 - 381 WP_208644314.1 hypothetical protein -
DMB82_RS07920 (DMB82_0007960) 1691489..1691626 + 138 WP_240348903.1 YnfU family zinc-binding protein -
DMB82_RS07925 (DMB82_0007965) 1691665..1691856 + 192 WP_116162547.1 hypothetical protein -
DMB82_RS07930 (DMB82_0007970) 1691944..1692867 + 924 WP_116162681.1 LpxL/LpxP family Kdo(2)-lipid IV(A) lauroyl/palmitoleoyl acyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1656312..1692867 36555


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(7-54)


Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15744.97 Da        Isoelectric Point: 6.7190

>T222832 WP_116162549.1 NZ_CP086253:1688754-1689182 [Pectobacterium aquaticum]
MLKYLLDTNICIYTIKNKPQEVRDAFYRHYGQFAISAITLMELIYGAEKSVNPEKNLAVIEGFSARLEVQTYGFDAAVHT
GQIRAELAKQGTPIGPYDAMLAGHARSAGLILVTNNVREFERVPGLRVENWVGSSADNSQPL

Download         Length: 429 bp

>T222832 NZ_CP118144:1221912-1222190 [Pseudomonas chlororaphis]
GTGAGGGAATTGAAATGGACGAGCAAGGCACTGTCGGACCTGGCCCGACTGTTTGAGTTTCTTGCTCCGGTGAACCGTTC
GGTGGCAGCTCGAACTGTGCACTCGCTCACGCAGGCCCCGGATACCCTGCTGATCAATCCGCGTATCGGCGAACAGTTGG
AGGAGTTTCAGCCTCGCGATGTTCGGCGTTTATTGGTCGGGCCTTACGAGATGCGTTACGAGATCCAGGATGCGACGCTC
TACATCTTGCGGGTGTGGCATGTACGAGAAGACCGCTAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8681.76 Da        Isoelectric Point: 4.4091

>AT222832 WP_116162551.1 NZ_CP086253:1688524-1688754 [Pectobacterium aquaticum]
MEKTTVFKSNRSQAVRLPKAVALPDDVKQVDIIAIGRTRIITPAGESWDSWFEGEGVTPDFMITREQQDDQIREDF

Download         Length: 231 bp

>AT222832 NZ_CP118144:1221652-1221915 [Pseudomonas chlororaphis]
ATGACCGCAACTAAAGTGCTGACCGCACATGTGCCGTTGGAGTTGGCCGACAAGGTCGACCAGATGGCCTCCCGGCTGGA
GCGCTCGCGCGGCTGGATCGTCAAGCAGGCTCTGGTAGCGTGGGTCGATCAGGAAGAGGAGCGCAGTCGCCTGACCCATG
AGGCTTTGGCCGATGTGGATGTTGGGCGGGTCATCGATCACCAGGCTGTCCAGGCATGGGCCGAGAGCCTGATGAATGAC
AAGCCTTTGCCGGTGCCCAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References