Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mazEF/PRK09907-MazE |
| Location | 1404206..1404790 | Replicon | chromosome |
| Accession | NZ_CP086253 | ||
| Organism | Pectobacterium aquaticum strain A212-S19-A16 | ||
Toxin (Protein)
| Gene name | mazF | Uniprot ID | - |
| Locus tag | DMB82_RS06605 | Protein ID | WP_102119239.1 |
| Coordinates | 1404206..1404538 (-) | Length | 111 a.a. |
Antitoxin (Protein)
| Gene name | mazE | Uniprot ID | A0A7T5U8Q8 |
| Locus tag | DMB82_RS06610 | Protein ID | WP_038925224.1 |
| Coordinates | 1404539..1404790 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| DMB82_RS06575 (DMB82_0006600) | 1399330..1401144 | + | 1815 | WP_102119168.1 | S-type pyocin domain-containing protein | - |
| DMB82_RS06580 (DMB82_0006605) | 1401141..1401608 | + | 468 | WP_107333216.1 | DUF6392 family protein | - |
| DMB82_RS06585 (DMB82_0006610) | 1401679..1401864 | - | 186 | WP_107333215.1 | hypothetical protein | - |
| DMB82_RS06590 (DMB82_0006615) | 1402213..1402683 | - | 471 | WP_228400056.1 | HAD hydrolase-like protein | - |
| DMB82_RS06595 (DMB82_0006620) | 1402811..1403938 | + | 1128 | WP_102119602.1 | ISAs1 family transposase | - |
| DMB82_RS06600 (DMB82_0006625) | 1403943..1404134 | - | 192 | WP_116163615.1 | HAD hydrolase-like protein | - |
| DMB82_RS06605 (DMB82_0006630) | 1404206..1404538 | - | 333 | WP_102119239.1 | endoribonuclease MazF | Toxin |
| DMB82_RS06610 (DMB82_0006635) | 1404539..1404790 | - | 252 | WP_038925224.1 | PbsX family transcriptional regulator | Antitoxin |
| DMB82_RS06615 (DMB82_0006640) | 1405361..1405693 | - | 333 | WP_102119240.1 | hypothetical protein | - |
| DMB82_RS06620 (DMB82_0006645) | 1405890..1406216 | - | 327 | Protein_1278 | tyrosine-type recombinase/integrase | - |
| DMB82_RS06625 (DMB82_0006650) | 1406463..1406972 | - | 510 | WP_116163616.1 | hypothetical protein | - |
| DMB82_RS06630 (DMB82_0006655) | 1407302..1408531 | - | 1230 | WP_167469159.1 | tyrosine-type recombinase/integrase | - |
| DMB82_RS06635 (DMB82_0006660) | 1408762..1408944 | + | 183 | Protein_1281 | hydroxyethylthiazole kinase | - |
| DMB82_RS06640 (DMB82_0006665) | 1408956..1409759 | + | 804 | WP_102118922.1 | bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 1402811..1403938 | 1127 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 111 a.a. Molecular weight: 12191.03 Da Isoelectric Point: 7.0819
>T222830 WP_102119239.1 NZ_CP086253:c1404538-1404206 [Pectobacterium aquaticum]
MVSRFVPDSGDLIWLDFDPVVGHEQGGHRPAVVLSPFPYNNLTGMCLCVPCTTQRKGYNFEVELSGDRESVALADQVTCV
DWRNRKATKKGKVTIDELELIRAKAKALIG
MVSRFVPDSGDLIWLDFDPVVGHEQGGHRPAVVLSPFPYNNLTGMCLCVPCTTQRKGYNFEVELSGDRESVALADQVTCV
DWRNRKATKKGKVTIDELELIRAKAKALIG
Download Length: 333 bp
>T222830 NZ_CP118144:c560120-559692 [Pseudomonas chlororaphis]
ATGATCGTGCTCGACACCAATGTGCTGTCGGAACTGATGCGTCCCCAACCGGACGCATCGGTATTGCTGTGGATCGAAGC
GCAACCTGTCGAAGACCTCTACATCAGCGCCATGACCATGGCCGAGATTCTTCACGGCATCGCGCGCCTGCCCCACGGCA
AGCGCAAACAGATGCTCCATGCGTCGGCCCTGGCGATGTTCGAGGAAGATTTCATCGACCGCATCGTGCCCTTCGGGACC
CAGGCGGCTCTTTACTACGCCCATCTGATTTCGCACCGGGAAAGCCTGGGGCGTCCGATCAGCCTGGTGGATGCGCAAAT
TGCGGCCATATGCCGCGTCCACGACGCGGCGATCGCCACCCGTAACGCCAAGGACTTCAGCGACACCGGGTTGATCGTTA
TCAACCCCTGGCTGCCACTCGAGGTTTGA
ATGATCGTGCTCGACACCAATGTGCTGTCGGAACTGATGCGTCCCCAACCGGACGCATCGGTATTGCTGTGGATCGAAGC
GCAACCTGTCGAAGACCTCTACATCAGCGCCATGACCATGGCCGAGATTCTTCACGGCATCGCGCGCCTGCCCCACGGCA
AGCGCAAACAGATGCTCCATGCGTCGGCCCTGGCGATGTTCGAGGAAGATTTCATCGACCGCATCGTGCCCTTCGGGACC
CAGGCGGCTCTTTACTACGCCCATCTGATTTCGCACCGGGAAAGCCTGGGGCGTCCGATCAGCCTGGTGGATGCGCAAAT
TGCGGCCATATGCCGCGTCCACGACGCGGCGATCGCCACCCGTAACGCCAAGGACTTCAGCGACACCGGGTTGATCGTTA
TCAACCCCTGGCTGCCACTCGAGGTTTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9466.97 Da Isoelectric Point: 4.8047
>AT222830 WP_038925224.1 NZ_CP086253:c1404790-1404539 [Pectobacterium aquaticum]
MIDVPVKKWGNSPAIRLSSSVMQAFDMTFNDSFDMEIRETEIALIPKKKPKYQFTLDELLEGMTPEHVHEKVDFGAPVGK
ELL
MIDVPVKKWGNSPAIRLSSSVMQAFDMTFNDSFDMEIRETEIALIPKKKPKYQFTLDELLEGMTPEHVHEKVDFGAPVGK
ELL
Download Length: 252 bp
>AT222830 NZ_CP118144:c560362-560117 [Pseudomonas chlororaphis]
ATGGCCAGCCTGACAATCCGAAACCTGGACGACCACATCAAAGAGCGCCTGCGCATCGAGGCCGCCCACAACGGCCACTC
CATGGAAGAAGAAGCCCGCTTGATTTTGCGCCGCGCCCTGAACAGAACAACCGACAGCCAAGGCCTGGCCAGTCGTATCC
GGGCACGCTTTGCCGAGGCCGGCGGAGTGAAGCTTGAGCTGCCCGAACGTACCGAGCCGGCACGCGTGGTGGATCTGGGC
GAATGA
ATGGCCAGCCTGACAATCCGAAACCTGGACGACCACATCAAAGAGCGCCTGCGCATCGAGGCCGCCCACAACGGCCACTC
CATGGAAGAAGAAGCCCGCTTGATTTTGCGCCGCGCCCTGAACAGAACAACCGACAGCCAAGGCCTGGCCAGTCGTATCC
GGGCACGCTTTGCCGAGGCCGGCGGAGTGAAGCTTGAGCTGCCCGAACGTACCGAGCCGGCACGCGTGGTGGATCTGGGC
GAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|