Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 429069..429853 Replicon chromosome
Accession NZ_CP086253
Organism Pectobacterium aquaticum strain A212-S19-A16

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag DMB82_RS01980 Protein ID WP_116164350.1
Coordinates 429359..429853 (+) Length 165 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID A0A3S0Y1Y3
Locus tag DMB82_RS01975 Protein ID WP_038921611.1
Coordinates 429069..429362 (+) Length 98 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DMB82_RS01950 (DMB82_0001960) 424645..425640 - 996 WP_039539586.1 LysR family transcriptional regulator -
DMB82_RS01955 (DMB82_0001965) 426194..426529 - 336 WP_102117174.1 hypothetical protein -
DMB82_RS01960 (DMB82_0001970) 427104..428049 + 946 Protein_376 IS30 family transposase -
DMB82_RS01965 (DMB82_0001975) 428046..428201 - 156 WP_228400031.1 hypothetical protein -
DMB82_RS01970 (DMB82_0001980) 428261..428632 - 372 WP_226887596.1 Arm DNA-binding domain-containing protein -
DMB82_RS01975 (DMB82_0001985) 429069..429362 + 294 WP_038921611.1 DUF1778 domain-containing protein Antitoxin
DMB82_RS01980 (DMB82_0001990) 429359..429853 + 495 WP_116164350.1 GNAT family N-acetyltransferase Toxin
DMB82_RS01985 (DMB82_0001995) 430024..430353 + 330 WP_116164352.1 hypothetical protein -
DMB82_RS01990 (DMB82_0002000) 431112..431327 + 216 Protein_382 helix-turn-helix domain-containing protein -
DMB82_RS01995 (DMB82_0002005) 432219..433295 + 1077 WP_116164356.1 hypothetical protein -
DMB82_RS02000 (DMB82_0002010) 433315..434010 + 696 WP_167469176.1 HAD family hydrolase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 427645..428049 404


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(66-143)

Antitoxin

(14-88)


Sequences


Toxin        


Download         Length: 165 a.a.        Molecular weight: 17728.56 Da        Isoelectric Point: 6.8526

>T222827 WP_116164350.1 NZ_CP086253:429359-429853 [Pectobacterium aquaticum]
MISAPEPLHAEHVLSSFCCGVESTDNWLKLRAMKNQVTGASRTFVSCNDSKVLAYYSLASSAMATNAAPGRFRRNMPDPI
PVVVLGRLAVDTSLHGQGVGRALVRDVGLRVIQVADTIGIRGMLVHALSDEAREFYLRVGFEPSPIDPMMLMVTLGDLVD
SLSI

Download         Length: 495 bp

>T222827 NZ_CP118143:c6350679-6350380 [Pseudomonas chlororaphis]
ATGATCGAGATCAAACAGACCGCGACCTTTATGGAGTGGGAAAACAGGCTCAAGGATTCCAGAGCCAGGGCGTTGATTGC
TGCGCGGATTTTTCGCCTGGCCAACGGTCTTGCCGGGGACGTGTCGCCGGTGGGCGAAGGCGTCAGTGAGCTGCGCATCC
ATTACGGGCCGGGCTACCGGGTTTACTTCCAGCAGCGCGGCTTGCAACTCGTCATCCTGTTGTGCGGCGGCGACAAGAGT
CGCCAGGGCCGCGATATCGAACTGGCCAAACAGCTGGCCCGTCGTTGGAGCCGATCATGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10824.38 Da        Isoelectric Point: 10.1968

>AT222827 WP_038921611.1 NZ_CP086253:429069-429362 [Pectobacterium aquaticum]
VPATNSVSVKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIDQRIIMADPDAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQKK

Download         Length: 294 bp

>AT222827 NZ_CP118143:c6350383-6350090 [Pseudomonas chlororaphis]
ATGAACGAACCGCTTTTCGACTATGACCCCGCCACGGCCCTGCGCGACCCGCAGGCCATTGCCCTGTTCATGGCGGACGC
CTTCGAGACCGGCGATGCCGGCTACATCGCCAAAGCCCTGGGCGTGGTGGCGCGGGCCAAGGGCATGACCGAACTGGCCC
ATGAAACCGGGCTGTCCCGCGAGCAGCTGTACCGCTCATTCAGCGACAAGGGCAACCCGACCCTGAAGACCCTGCTGGCG
GTGATGCGTGCACTGGGGCTGGACATGACGGCGCGGGTGCATGGGGCGTCTTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A3S0Y1Y3

References