Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yoeB-relB/YoeB-RelB
Location 218248..218752 Replicon plasmid pDSM14864-244
Accession NZ_CP086250
Organism Clostridium estertheticum strain DSM 14864

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag LL032_RS23915 Protein ID WP_151553814.1
Coordinates 218248..218505 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag LL032_RS23920 Protein ID WP_151553813.1
Coordinates 218498..218752 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LL032_RS23895 (LL032_23885) 213815..214366 + 552 WP_151553818.1 GNAT family N-acetyltransferase -
LL032_RS23900 (LL032_23890) 214618..215571 - 954 WP_151553817.1 stage II sporulation protein P -
LL032_RS23905 (LL032_23895) 215683..217434 - 1752 WP_151553816.1 M56 family metallopeptidase -
LL032_RS23910 (LL032_23900) 217440..217823 - 384 WP_151553815.1 BlaI/MecI/CopY family transcriptional regulator -
LL032_RS23915 (LL032_23905) 218248..218505 - 258 WP_151553814.1 Txe/YoeB family addiction module toxin Toxin
LL032_RS23920 (LL032_23910) 218498..218752 - 255 WP_151553813.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LL032_RS23925 (LL032_23915) 219254..219478 + 225 WP_151553812.1 hypothetical protein -
LL032_RS23930 (LL032_23920) 220310..220525 + 216 WP_268034107.1 Tn3 family transposase -
LL032_RS23935 (LL032_23925) 220682..221326 - 645 WP_151553810.1 hypothetical protein -
LL032_RS23940 (LL032_23930) 221453..222100 - 648 WP_170288062.1 CYTH domain-containing protein -
LL032_RS23945 (LL032_23935) 222469..223281 - 813 WP_170288061.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..243849 243849


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-70)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10206.55 Da        Isoelectric Point: 6.9774

>T222822 WP_151553814.1 NZ_CP086250:c218505-218248 [Clostridium estertheticum]
MNKIFSEVSWEHYVYWQSEDKKILRKINELIKDIERNGNEGLGKPEALKHELVGYWSRRITDVHRLIYSIDDENIYVASC
KGHYH

Download         Length: 258 bp

>T222822 NZ_CP118143:1221894-1222172 [Pseudomonas chlororaphis]
GTGAGGGAATTGAAATGGACGAGCAAGGCACTGTCGGACCTGGCCCGACTGTTTGAGTTTCTTGCTCCGGTGAACCGTTC
GGTGGCAGCTCGAACTGTGCACTCGCTCACGCAGGCCCCGGATACCCTGCTGATCAATCCGCGTATCGGCGAACAGTTGG
AGGAGTTTCAGCCTCGCGATGTTCGGCGTTTATTGGTCGGGCCTTACGAGATGCGTTACGAGATCCAGGATGCGACGCTC
TACATCTTGCGGGTGTGGCATGTACGAGAAGACCGCTAG

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9805.16 Da        Isoelectric Point: 5.1086

>AT222822 WP_151553813.1 NZ_CP086250:c218752-218498 [Clostridium estertheticum]
MIAIGYSNARQNFKNYCDKATKDFETIIITRERGDNVVMLSESAYNNLMENLYVRSDPTYYNELLKSIDQLKMGKGIRKE
LLDE

Download         Length: 255 bp

>AT222822 NZ_CP118143:1221634-1221897 [Pseudomonas chlororaphis]
ATGACCGCAACTAAAGTGCTGACCGCACATGTGCCGTTGGAGTTGGCCGACAAGGTCGACCAGATGGCCTCCCGGCTGGA
GCGCTCGCGCGGCTGGATCGTCAAGCAGGCTCTGGTAGCGTGGGTCGATCAGGAAGAGGAGCGCAGTCGCCTGACCCATG
AGGCTTTGGCCGATGTGGATGTTGGGCGGGTCATCGATCACCAGGCTGTCCAGGCATGGGCCGAGAGCCTGATGAATGAC
AAGCCTTTGCCGGTGCCCAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References