Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yoeB-relB/YoeB-RelB
Location 6080..6584 Replicon plasmid pCF011-68
Accession NZ_CP086248
Organism Clostridium sp. CF011

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag LL036_RS18795 Protein ID WP_216304438.1
Coordinates 6327..6584 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag LL036_RS18790 Protein ID WP_216304437.1
Coordinates 6080..6334 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LL036_RS18760 (LL036_18695) 1605..1829 + 225 WP_216304432.1 DUF1659 domain-containing protein -
LL036_RS18765 (LL036_18700) 1888..2124 + 237 WP_216304433.1 DUF2922 domain-containing protein -
LL036_RS18770 (LL036_18705) 2312..3091 + 780 WP_216304434.1 N-acetylmuramoyl-L-alanine amidase -
LL036_RS18775 3147..3272 + 126 WP_258280793.1 hypothetical protein -
LL036_RS18780 (LL036_18710) 3336..3542 - 207 WP_216304435.1 hypothetical protein -
LL036_RS18785 (LL036_18715) 4890..5363 - 474 WP_216304436.1 ASCH domain-containing protein -
LL036_RS18790 (LL036_18720) 6080..6334 + 255 WP_216304437.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LL036_RS18795 (LL036_18725) 6327..6584 + 258 WP_216304438.1 Txe/YoeB family addiction module toxin Toxin
LL036_RS18800 (LL036_18730) 7513..7746 + 234 WP_268064233.1 RepB family plasmid replication initiator protein -
LL036_RS18805 (LL036_18735) 8000..9175 - 1176 WP_216304439.1 replication initiation protein -
LL036_RS18810 (LL036_18740) 10085..10291 + 207 WP_216304440.1 hypothetical protein -
LL036_RS18815 (LL036_18745) 10480..11358 + 879 WP_216304441.1 CPBP family intramembrane metalloprotease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..68240 68240


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10220.58 Da        Isoelectric Point: 6.9776

>T222821 WP_216304438.1 NZ_CP086248:6327-6584 [Clostridium sp. CF011]
MNKIFSEVSWEHYVYWQSEDKKILRKINELIKDIERNGNEGLGKPEALKHELVGYWSRRITEVHRLIYSIDDENIYVASC
KGHYH

Download         Length: 258 bp

>T222821 NZ_CP118143:780791-781087 [Pseudomonas chlororaphis]
ATGCGTGTAATCACGGCTAAACGAATTTGGGATGCCAAGGAAAAATGGCCACAGTCGGCCAAGGCGTTGGATGATTGGTA
TCGCGCGCTTAAACGCAATCGGCTTGCGGATTTTGCCGCGATGAAGGCGATGTTTCCGGCGGTGGACAAGGTCGGACCGC
TGCATGTGTTCGATATCGGTGGCAACAAGATACGACTGATTGCATTGGTCCGTTATACGACGCAAAAGCTCTATATCCGC
CATGTGTTGGACCACCGTGAATATGACCGGGGTAAGTGGAAGGAGGATCGAGGATGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9848.18 Da        Isoelectric Point: 4.6151

>AT222821 WP_216304437.1 NZ_CP086248:6080-6334 [Clostridium sp. CF011]
MIAIGYSNVRQNFKNYCDKATKDFETIIITRERGDNVVMLSESAYNNLMENLYVRSDPTYYNELLKSIEQLKMGKGIERE
LLDE

Download         Length: 255 bp

>AT222821 NZ_CP118143:781084-781485 [Pseudomonas chlororaphis]
ATGAGTGCATTGATCGAGCAAGTGGCCGAACACTGGCAGTTCGTTGCGCCGTTGCTGCGCAAGCCGAAAACCGAGGCGGA
CTACGACAGGCTGGTTCAGGCCCTTGACGAGTTGTTGGACCTGACAGGGGAAGATGAGGCCCATCCTCTCAACAGCCTGG
TGGACATCATCGGGGACTGGATCGAAGCCTACGATCTTGAACATCGCCCGATGCCTGTTGCCAGCGGAATAGATGTGTTG
CGCTACATGATGCGCGAACACGGTCTGACCCAGAGCGACCTGCCCGGTGTCGGCGCGCAGTCGGTAGTCTCGGAGATCCT
GAGCGGCAAGCGTCAGCTCAACCTGCGTCAGATCCGCTGGCTGGCCGAACGTTTCAAGGTCTCGATGGAAACCTTTATCT
GA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References