Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | chpSB/PRK09812-ChpS |
Location | 4516523..4517118 | Replicon | chromosome |
Accession | NZ_CP086220 | ||
Organism | Escherichia coli strain 779 |
Toxin (Protein)
Gene name | chpB | Uniprot ID | U9Y4M4 |
Locus tag | LMB17_RS21875 | Protein ID | WP_000239579.1 |
Coordinates | 4516768..4517118 (+) | Length | 117 a.a. |
Antitoxin (Protein)
Gene name | chpS | Uniprot ID | U9Y2K1 |
Locus tag | LMB17_RS21870 | Protein ID | WP_001223208.1 |
Coordinates | 4516523..4516774 (+) | Length | 84 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LMB17_RS21860 (4512188) | 4512188..4515967 | + | 3780 | WP_000060895.1 | autotransporter assembly complex protein TamB | - |
LMB17_RS21865 (4515970) | 4515970..4516311 | + | 342 | WP_001219160.1 | gamma-glutamylcyclotransferase | - |
LMB17_RS21870 (4516523) | 4516523..4516774 | + | 252 | WP_001223208.1 | type II toxin-antitoxin system antitoxin ChpS | Antitoxin |
LMB17_RS21875 (4516768) | 4516768..4517118 | + | 351 | WP_000239579.1 | endoribonuclease toxin ChpB | Toxin |
LMB17_RS21880 (4517198) | 4517198..4517728 | - | 531 | WP_000055072.1 | inorganic diphosphatase | - |
LMB17_RS21885 (4518038) | 4518038..4518994 | + | 957 | WP_000265933.1 | galactofuranose ABC transporter substrate-binding protein YtfQ | - |
LMB17_RS21890 (4519304) | 4519304..4520806 | + | 1503 | WP_000205794.1 | sugar ABC transporter ATP-binding protein | - |
LMB17_RS21895 (4520820) | 4520820..4521842 | + | 1023 | WP_001296689.1 | ABC transporter permease | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 12511.45 Da Isoelectric Point: 5.6219
>T222812 WP_000239579.1 NZ_CP086220:4516768-4517118 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE
Download Length: 351 bp
>T222812 NZ_CP118142:c2785521-2785171 [Pseudomonas chlororaphis]
ATGGACGCACTTTTTATTGAGCTGCCCCCGTTCCAACGCCATCGACAGGACTACCTGGACGACGAGCTTTTTCGTAGCTT
GCAGCTTGAATTGCTGAAAGCCCCCGAAGCCGGAGATCTCATCGAGGGAGTCGGTGGCTTGCGCAAGATCCGCTTTGTCG
ATGAGCGACGGCACAAGGGCAAACGCGGCGGGATCCGGGTGATTTATTACTGGTGGTCCGGAGGCGCCCAGTTCTGGCTC
TTCACCCTTTACGCAAAGAACGAGCAGAACGACCTGACATCCCATCAGAAAAAACTGCTCAAGCAACTGCTGAACAGAGA
AGTCGAGGCGAGAACCCATCATGAAACGTGA
ATGGACGCACTTTTTATTGAGCTGCCCCCGTTCCAACGCCATCGACAGGACTACCTGGACGACGAGCTTTTTCGTAGCTT
GCAGCTTGAATTGCTGAAAGCCCCCGAAGCCGGAGATCTCATCGAGGGAGTCGGTGGCTTGCGCAAGATCCGCTTTGTCG
ATGAGCGACGGCACAAGGGCAAACGCGGCGGGATCCGGGTGATTTATTACTGGTGGTCCGGAGGCGCCCAGTTCTGGCTC
TTCACCCTTTACGCAAAGAACGAGCAGAACGACCTGACATCCCATCAGAAAAAACTGCTCAAGCAACTGCTGAACAGAGA
AGTCGAGGCGAGAACCCATCATGAAACGTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9271.58 Da Isoelectric Point: 4.4201
>AT222812 WP_001223208.1 NZ_CP086220:4516523-4516774 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW
Download Length: 252 bp
>AT222812 NZ_CP118142:c2785181-2784867 [Pseudomonas chlororaphis]
ATGAAACGTGACATCTTTTCCGAACTGGTCGAAGGTTTCGACACCCTGGCCAAAGAGCGCCAAGGCAAGCTCACGCTGCG
CACCCACAAGGTCAAGCTGAACGCACTGCTACCGATCACCGCTGAAGAAGTGCTGGCCGTGCGCGAACAGCTGAACCTGT
CCAGATCGGTATTTGCCATGTACCTGCGCACCAATACTCGGACCCTGGAGAACTGGGAGCAAGGACGGGCAAAACCCAAC
GCCCAGGCCACCACCCTGATCCGCCTGGTACAGCGTTTTCCCGATACGGTGGAGCGGCTGGCAGCCCTTGCCTGA
ATGAAACGTGACATCTTTTCCGAACTGGTCGAAGGTTTCGACACCCTGGCCAAAGAGCGCCAAGGCAAGCTCACGCTGCG
CACCCACAAGGTCAAGCTGAACGCACTGCTACCGATCACCGCTGAAGAAGTGCTGGCCGTGCGCGAACAGCTGAACCTGT
CCAGATCGGTATTTGCCATGTACCTGCGCACCAATACTCGGACCCTGGAGAACTGGGAGCAAGGACGGGCAAAACCCAAC
GCCCAGGCCACCACCCTGATCCGCCTGGTACAGCGTTTTCCCGATACGGTGGAGCGGCTGGCAGCCCTTGCCTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0E0Y8A8 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U9LQ26 |