Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3034415..3035213 Replicon chromosome
Accession NZ_CP086220
Organism Escherichia coli strain 779

Toxin (Protein)


Gene name yeeV Uniprot ID U9XMP3
Locus tag LMB17_RS14820 Protein ID WP_000854735.1
Coordinates 3034836..3035213 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A067H947
Locus tag LMB17_RS14815 Protein ID WP_001285415.1
Coordinates 3034415..3034789 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LMB17_RS14780 (3030346) 3030346..3031026 + 681 WP_001282919.1 WYL domain-containing protein -
LMB17_RS14785 (3031174) 3031174..3031851 + 678 WP_001097302.1 hypothetical protein -
LMB17_RS14790 (3031857) 3031857..3032090 + 234 WP_001278287.1 DUF905 family protein -
LMB17_RS14795 (3032180) 3032180..3032998 + 819 WP_072644953.1 DUF932 domain-containing protein -
LMB17_RS14800 (3033080) 3033080..3033559 + 480 WP_000844100.1 antirestriction protein -
LMB17_RS14805 (3033575) 3033575..3034051 + 477 WP_001366855.1 RadC family protein -
LMB17_RS14810 (3034114) 3034114..3034335 + 222 WP_000692309.1 DUF987 domain-containing protein -
LMB17_RS14815 (3034415) 3034415..3034789 + 375 WP_001285415.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
LMB17_RS14820 (3034836) 3034836..3035213 + 378 WP_000854735.1 TA system toxin CbtA family protein Toxin
LMB17_RS14825 (3035210) 3035210..3035698 + 489 WP_000761676.1 DUF5983 family protein -
LMB17_RS14830 (3035710) 3035710..3035907 + 198 WP_000839291.1 DUF957 domain-containing protein -
LMB17_RS14835 (3035992) 3035992..3036858 + 867 WP_001280433.1 DUF4942 domain-containing protein -
LMB17_RS14840 (3036930) 3036930..3037193 + 264 WP_001143297.1 type II toxin-antitoxin system ParD family antitoxin -
LMB17_RS14845 (3037190) 3037190..3037516 + 327 WP_000779483.1 type II toxin-antitoxin system RelE/ParE family toxin -
LMB17_RS14850 (3037980) 3037980..3039242 + 1263 WP_001218875.1 integrase arm-type DNA-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2986458..3037782 51324


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14061.07 Da        Isoelectric Point: 8.2904

>T222806 WP_000854735.1 NZ_CP086220:3034836-3035213 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T222806 NZ_CP118141:1215628-1215906 [Pseudomonas chlororaphis]
GTGAGGGAATTGAAATGGACGAGCAAGGCACTGTCGGACCTGGCCCGACTGTTTGAGTTTCTTGCTCCGGTGAACCGTTC
GGTGGCAGCTCGAACTGTGCAATCGCTCACGCAGGCCCCGGATACCTTGCTGACCAATCCGCGTATCGGCGAACAGTTGG
AGGAGTTTCAGCCTCGCGATGTTCGGCGTTTATTGGTCGGGCCTTACGAGATGCGTTACGAGATCCAGGATGCGACGCTC
TACATCCTGCGAGTGTGGCATGTACGAGAAGACCGCTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13663.32 Da        Isoelectric Point: 5.8640

>AT222806 WP_001285415.1 NZ_CP086220:3034415-3034789 [Escherichia coli]
VSDTHPGTTHPDNNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT222806 NZ_CP118141:1215368-1215631 [Pseudomonas chlororaphis]
ATGACCGCAACTAAAGTGCTGACCGCACATGTGCCGTTGGAGTTGGCCGACAAGGTCGACCAGATGGCCTCTCGGCTGGA
GCGCTCGCGCGGCTGGATCGTCAAGCAGGCTCTGGTGGCGTGGGTCGATCAGGAAGAGGAACGCAGTCGCCTGACCCATG
AGGCTTTGGCCGATGTGGATGTTGGGCGGGTCATCGATCACCAGGCGGTCCAGGCATGGGCTGAAAGCCTGATGAGTGAC
AAGCCTTTGCCGGTGCCCAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XMP3

Antitoxin

Source ID Structure
AlphaFold DB A0A067H947

References