222777

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2770792..2771306 Replicon chromosome
Accession NZ_CP086215
Organism Staphylococcus aureus strain Patient 14 Isolate 02

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag LLZ98_RS13795 Protein ID WP_000581792.1
Coordinates 2771097..2771306 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag LLZ98_RS13790 Protein ID WP_000138932.1
Coordinates 2770792..2771085 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LLZ98_RS13770 (2765955) 2765955..2766596 + 642 WP_000483153.1 thiamine phosphate synthase -
LLZ98_RS13775 (2766682) 2766682..2767554 + 873 WP_000725802.1 membrane protein insertase YidC -
LLZ98_RS13780 (2768467) 2768467..2769114 - 648 WP_001187630.1 HD domain-containing protein -
LLZ98_RS13785 (2769142) 2769142..2770626 - 1485 WP_000571549.1 cardiolipin synthase -
LLZ98_RS13790 (2770792) 2770792..2771085 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
LLZ98_RS13795 (2771097) 2771097..2771306 + 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
LLZ98_RS13800 (2771434) 2771434..2771571 + 138 WP_000828354.1 Lmo0850 family protein -
LLZ98_RS13805 (2771835) 2771835..2773037 - 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
LLZ98_RS13810 (2773355) 2773355..2774425 + 1071 WP_000159631.1 D-alanine--D-alanine ligase -
LLZ98_RS13815 (2774440) 2774440..2775798 + 1359 WP_000611464.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T222777 WP_000581792.1 NZ_CP086215:2771097-2771306 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T222777 NZ_CP118137:c2613139-2612957 [Pseudomonas chlororaphis]
GTGCAAAGCAGACAGTTGATCAAGGAGCTTGAAGCCGCAGGCTGGGTGCTGGAGCGCGTTACCGGTAGCCATCATCTGTT
CAAGCATCCCTACCGGCCCGAGACCGTTCCGGTGCCTCACCCGAAGAAAGATCTGCCACGGGGGACGGTCAGGGCCATCC
AGAAACTGGCCGGGCTGATATAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT222777 WP_000138932.1 NZ_CP086215:2770792-2771085 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT222777 NZ_CP118137:c2612921-2612520 [Pseudomonas chlororaphis]
GTGCAATATCCCATCTGCATCGAGTGGGGCGACGAGCACACTGCTACCGGCATCCAGATTCCTGACATTCCGGGCGCGGT
AACCGCCGGCGACACCTTCGAGGCCGCGTATAGCGCCGCCATCGAGATCGCCCACGTCATGCTCGAAGAGCTGGCCCGTG
AGGGGCAAGCCATTCCCCTGCCCTCGCCCACCGGCACGCACCGCGCCAACCCCGACTTCGAGGGGATGGGCTGGGGCATG
CTGGATATCGATATCACGCCTTACCTGGGCAAAACCGAGAAGGTCAATGTGACCCTGCCGGGTTACGTGATTCAACGAAT
CGACCGCTTTGTGCGGGAGCACAACATCAAGAGCCGATCGTCATTCCTGGCGGATGCGGCGATGGAAAAGCTGGGGCGTT
AA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References