222769

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 2395509..2396032 Replicon chromosome
Accession NZ_CP086215
Organism Staphylococcus aureus strain Patient 14 Isolate 02

Toxin (Protein)


Gene name relE Uniprot ID A0A3A5LQI3
Locus tag LLZ98_RS11840 Protein ID WP_000074049.1
Coordinates 2395766..2396032 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag LLZ98_RS11835 Protein ID WP_000587616.1
Coordinates 2395509..2395766 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LLZ98_RS11820 (2392006) 2392006..2392755 - 750 WP_000072461.1 CPBP family lipoprotein N-acylation protein LnsB -
LLZ98_RS11825 (2392950) 2392950..2394527 + 1578 WP_000143494.1 FMN-binding glutamate synthase family protein -
LLZ98_RS11830 (2394695) 2394695..2395150 - 456 WP_000732076.1 DUF1307 domain-containing protein -
LLZ98_RS11835 (2395509) 2395509..2395766 + 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LLZ98_RS11840 (2395766) 2395766..2396032 + 267 WP_000074049.1 Txe/YoeB family addiction module toxin Toxin
LLZ98_RS11845 (2396387) 2396387..2397463 + 1077 WP_001076673.1 M42 family metallopeptidase -
LLZ98_RS11850 (2397711) 2397711..2398373 + 663 WP_000923526.1 ATP-binding cassette domain-containing protein -
LLZ98_RS11855 (2398366) 2398366..2399142 + 777 WP_000072149.1 iron export ABC transporter permease subunit FetB -
LLZ98_RS11860 (2399538) 2399538..2400725 + 1188 WP_000026189.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10676.24 Da        Isoelectric Point: 10.1597

>T222769 WP_000074049.1 NZ_CP086215:2395766-2396032 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLRKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T222769 NZ_CP118136:4672366-4672716 [Pseudomonas chlororaphis]
ATGGACGCACTTTTTATTGAGCTGCCCCCGTTCCAACGCCATCGACAGGACTACCTGGACGACGAGCTTTTTCGTAGCTT
GCAGCTTGAGTTGCTGAAAGCCCCCGAAGCCGGAGATCTCATCGAGGGAACCGATGGCTTGCGCAAGATCCGCTTTGTCG
ATGAGCGACGGCACAAGGGCAAACGCGGCGGGATCCGGGTGATTTATTACTGGTGGTCCGGAGGCGCCCAATTCTGGCTC
TTCACCCTTTACGCAAAGAACGAGCAGAACGACCTGACACCCCATCAGAAAAAACTGCTCAAGCAACTGCTGAACAGAGA
AGTCGAGGCGAGAACCCATCATGAAACGTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT222769 WP_000587616.1 NZ_CP086215:2395509-2395766 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT222769 NZ_CP118136:4672706-4673020 [Pseudomonas chlororaphis]
ATGAAACGTGACATCTTTTCCGAACTGGTCGAAGGTTTCGACGCCCTGGCCAAAGAGCGCCAAGGCAAGCTCACGCTGCG
CACCTACAAGGTCAAGCTGAACGCGCTGCTCCCGATCACCGCTGAAGAAGTGCTGGCCGTGCGCGAGCAGTTGAACCTGT
CCAGATCGGTATTTGCCATGTACCTGCGCATCAATACTCGGACCCTGGAGAACTGGGAGCAAGGACGGGCAAAACCCAAC
GCTCAGGCCACCACCCTGATCCGCCTGGTACAGCGTTTTCCCGATACGGTGGAGCGGCTGGCAGCACTGGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A5LQI3

Antitoxin

Source ID Structure
AlphaFold DB W8TQT5

References