Detailed information of TA system TA222768

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 1249419..1249896
• Replicon: chromosome
• Accession: NZ_CP086215
• Organism: Staphylococcus aureus strain Patient 14 Isolate 02

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: T1Y7S2
• Locus tag: LLZ98_RS06420
• Protein ID: WP_000052076.1
• Coordinates: 1249708..1249896 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: T1Y6P8
• Locus tag: LLZ98_RS06415
• Protein ID: WP_001059690.1
• Coordinates: 1249419..1249679 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LLZ98_RS06380 (1244812)	1244812..1245528	-	717	WP_000150011.1	type I 3-dehydroquinate dehydratase	-
LLZ98_RS06385 (1245676)	1245676..1246098	+	423	WP_000974460.1	organic hydroperoxide resistance protein	-
LLZ98_RS06390 (1246497)	1246497..1246991	+	495	WP_000569883.1	GNAT family N-acetyltransferase	-
LLZ98_RS06395 (1247146)	1247146..1247763	+	618	WP_000255551.1	LysE/ArgO family amino acid transporter	-
LLZ98_RS06400 (1247836)	1247836..1248417	-	582	WP_001140693.1	histidine phosphatase family protein	-
LLZ98_RS06405 (1248642)	1248642..1248878	+	237	WP_000349581.1	hypothetical protein	-
LLZ98_RS06410 (1248875)	1248875..1249078	-	204	WP_000145163.1	sterile alpha motif-like domain-containing protein	-
LLZ98_RS06415 (1249419)	1249419..1249679	+	261	WP_001059690.1	hypothetical protein	Antitoxin
LLZ98_RS06420 (1249708)	1249708..1249896	+	189	WP_000052076.1	hypothetical protein	Toxin
LLZ98_RS06425 (1250084)	1250084..1250653	+	570	WP_001106658.1	lipoprotein N-acylation protein LnsA	-
LLZ98_RS06430 (1250741)	1250741..1251010	+	270	WP_001004398.1	hypothetical protein	-
LLZ98_RS06435 (1251087)	1251087..1251305	+	219	WP_000005886.1	hypothetical protein	-
LLZ98_RS06440 (1251797)	1251797..1251997	-	201	WP_001059082.1	cold-shock protein	-
LLZ98_RS06445 (1252354)	1252354..1253040	-	687	WP_000141557.1	thermonuclease family protein	-
LLZ98_RS06450 (1253381)	1253381..1253902	-	522	WP_000824482.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (1-54)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-127)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7142.82 Da
• Isoelectric Point: 9.9971

>T222768 WP_000052076.1 NZ_CP086215:1249708-1249896 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T222768 NZ_CP118136:c3003951-3003784 [Pseudomonas chlororaphis]
TTGATCAAGGAGCTTGAAGCCGCAGGCTGGGTGCTGGAGCGCGTTACCGGCAGCCATCATCTGTTCAAGCATCCCTACCG
GCCGGAGACCGTTCCAGTGCCTCACCCGAAGAAGGATCTGCCACGGGGGACGGTCAGGGCCATCCAGAAACTGGCCGGGC
TGATATAG

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9940.09 Da
• Isoelectric Point: 4.0624

>AT222768 WP_001059690.1 NZ_CP086215:1249419-1249679 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Nucleotide

• Length: 261 bp

>AT222768 NZ_CP118136:c3003748-3003347 [Pseudomonas chlororaphis]
GTGCAATATCCCATCTGCATCGAGTGGGGCGACGAGCACACTGCTACCGGCATCCAGATTCCTGACATTCCTGGCGCGGT
CACCGCCGGCGACACCTTCGAGGCCGCGTACAGCGCCGCCATCGAGATCGCCCACGTCATGCTCGAAGAGCTGGCCCGCG
AGGGGCAAACCATTCCCCTGCCCTCGCCCACCGGCACACACCGCGCCAACCCCGACTTCGAGGGGATGGGCTGGGGCATG
CTGGATATCGATATCACGCCTTACCTGGGCAAAACCGAAAAGGTCAATGTGACCCTGCCGGGTTATGTGATTCAGCGGAT
TGATCGCTTTGTGCGGGAGCACAACATCAAGAGCCGGTCGTCTTTCCTGGCGGATGCGGCGATGGAAAAGCTGGGGCGTT
AA

Structures

Toxin

• AlphaFold DB: A0A0E0VP18

Antitoxin

• AlphaFold DB: A0A0E0VN56