Detailed information of TA system TA222762

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 121096..121872
• Replicon: chromosome
• Accession: NZ_CP086215
• Organism: Staphylococcus aureus strain Patient 14 Isolate 02

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: X5E2E6
• Locus tag: LLZ98_RS00785
• Protein ID: WP_000031108.1
• Coordinates: 121720..121872 (+)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: W8U4V4
• Locus tag: LLZ98_RS00780
• Protein ID: WP_001251224.1
• Coordinates: 121096..121695 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LLZ98_RS00760 (117012)	117012..118469	+	1458	WP_000649908.1	ABC transporter permease subunit	-
LLZ98_RS00765 (118462)	118462..119184	+	723	WP_000590809.1	amino acid ABC transporter ATP-binding protein	-
LLZ98_RS00770 (119335)	119335..120462	+	1128	WP_000379980.1	tRNA epoxyqueuosine(34) reductase QueG	-
LLZ98_RS00775 (120467)	120467..120937	+	471	WP_000181395.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
LLZ98_RS00780 (121096)	121096..121695	+	600	WP_001251224.1	glucosamine-6-phosphate isomerase	Antitoxin
LLZ98_RS00785 (121720)	121720..121872	+	153	WP_000031108.1	SAS053 family protein	Toxin
LLZ98_RS00790 (122420)	122420..122815	+	396	WP_000901023.1	hypothetical protein	-
LLZ98_RS00795 (123011)	123011..124396	+	1386	WP_000116228.1	class II fumarate hydratase	-
LLZ98_RS00800 (124849)	124849..125670	-	822	WP_000669376.1	RluA family pseudouridine synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (124-196)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5936.28 Da
• Isoelectric Point: 3.8962

>T222762 WP_000031108.1 NZ_CP086215:121720-121872 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Nucleotide

• Length: 153 bp

>T222762 NZ_CP118135:6437291-6437935 [Pseudomonas chlororaphis]
ATGAATTACAGCAGACTGAATCCAGAGAAAGCTCTGATCTGGCGTATCGTCCATCGCGACAATCTGCCTTGGATTCTGGA
CAACGGTCTGCATTGCGCAAGCTCCGACGTACAGGCACCACAGTATGTGAATATTGGCAACGTTGACCTGATCAGCAAGC
GCCGATCCCGTCATGTGCCCATTACTCCAGGTGGGGTACTGGCCGATTACGTGCCCTTCTATTTCACCCCCTTCTCTGTG
ATGATGAAAAACATTCACTCAGGGTGGAGTGTTCAACAGCGAAGCAACGACGAGATAGTGATTCTGGTCTCAAGTTTGTA
CCGCGTTGAGCAGTTAGGTTTACCGTTTGTCTTCACAAATGCACATGCCTACCCGGATTGGACAAACTATTACAGCGATC
TGGCGAATCTCAGCCAGATCGACTGGTCTATCCTTCAGCGACGCGACTTCAAGCGCGACCCTGATGACCCTCGAAAAATG
GAGCGCTATCAGGCTGAAGCGCTAATTCACCATCACCTACCGATTACAGGACTCCTTGGCATCATGTGCCACACCGATGC
AATGAAAGAATGCATAGAACAAGACGTGACCGACAGAGGGTTGGCCTTACCTGTTCATGCCCGTCCGGGATGGTATTTCC
AATGA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22343.47 Da
• Isoelectric Point: 5.1445

>AT222762 WP_001251224.1 NZ_CP086215:121096-121695 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Nucleotide

• Length: 600 bp

>AT222762 NZ_CP118135:6437932-6439020 [Pseudomonas chlororaphis]
ATGATCCGTTTTACCCAAGGCAACCTTCTGGAAGCCAAAACCGAAGCCCTGGTCAACACGGTGAATACCGTAGGCGTAAT
GGGTAAAGGTATCGCGCTGATGTTTAAAGAGCGCTTTTCTGAGAATTACCGTCTGTACTCGGCTGCCTGTAAGGCTGGCG
AAGTGGAGACAGGCAGAATGCACGTGACAGCCGTCAACGAGCTGGACGGACCTCGCTGGATCGTGAATTTCCCAACCAAA
CGTCACTGGCGATCACCGTCGCAGATGGCTTGGGTGACGGAAGGTTTGCATGACTTACGTCGCTTCTTGATTGAAAACCA
GGTGAAGTCAGTGGCGGTTCCACCACTAGGAGCCGGCAATGGCGGCTTAAAATGGCCTGAAGTTCGCGAACAGATAGTCA
CCGTATTGGGTGACCTGGATGTGGACATTCTGGTGTTCGAGCCCTCCAACCAGTATTTGAATGTCGCCAAGCGTAGCGGT
GTGGAAAAGCTCACACCTGCTCGTGCCCTAATTGCCGAACTGGTTCGACGCTATTGGATTTTAGGCATGGAATGCAGCTT
GCTTGAAATTCAGAAACTAGCTTGGTTTCTTGAACGAGCTATAGAAAAGCTACCGGCCACCGAAAACCCATTGAACCTTA
AATTTGTGGCTCACAAATACGGACCGTACGCCAACAGACTGGAGCATCTACTCAATAACCTGGATGGGAGCTATCTGCAC
TGCAACAAACGCATCAGCGATGCGGGTATCAGTGATGTGATCTGGTTTGATGAAGAGCGTAAAGCCTTTCTGCAAACCTA
TCTCAAGACAGAAGCCAAGGAGTACTCACAAGCTCTGGAGCATACTGCCAAGCTGATTGATGGCTTTGAGTCCCCCTTCG
GTATGGAGTTATTGGCAACGGTCGATTGGTTGCTGAGTCAAGAAGGGATTTCTCCAACTGTTCCTGCCATGCGCGACGCG
TTGAAGAATTGGGATGGCGGAGCCGGTGCTGCTGTCCGAAAAAGCAGGCTGTTCGACGATCAGGCGCTTGATATCGCGCT
CAAACGCCTGACCTCAAGTAGTTTCATGCCTGAAATGGCTACCTGTTAG

Structures

Toxin

• AlphaFold DB: X5E2E6

Antitoxin

• AlphaFold DB: W8U4V4