Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/-
Location 4069586..4070807 Replicon chromosome
Accession NZ_CP086213
Organism Pseudomonas aeruginosa strain Pa3

Toxin (Protein)


Gene name vapC Uniprot ID A0A0H2Z8V4
Locus tag LLJ53_RS19150 Protein ID WP_003110488.1
Coordinates 4070229..4070807 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LLJ53_RS19145 Protein ID WP_003088112.1
Coordinates 4069586..4070140 (+) Length 185 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LLJ53_RS19120 (LLJ53_19120) 4065154..4065705 + 552 WP_003450159.1 XRE family transcriptional regulator -
LLJ53_RS19125 (LLJ53_19125) 4065702..4066100 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
LLJ53_RS19130 (LLJ53_19130) 4066113..4066436 - 324 WP_015648646.1 multidrug efflux SMR transporter -
LLJ53_RS19135 (LLJ53_19135) 4066767..4067228 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
LLJ53_RS19140 (LLJ53_19140) 4067233..4069428 + 2196 WP_003122807.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
LLJ53_RS19145 (LLJ53_19145) 4069586..4070140 + 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
LLJ53_RS19150 (LLJ53_19150) 4070229..4070807 + 579 WP_003110488.1 HD domain-containing protein Toxin
LLJ53_RS19155 (LLJ53_19155) 4070916..4072103 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
LLJ53_RS19160 (LLJ53_19160) 4072093..4074264 - 2172 WP_025297367.1 type I secretion system permease/ATPase -
LLJ53_RS19165 (LLJ53_19165) 4074254..4075531 - 1278 WP_003102743.1 TolC family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(7-188)

Antitoxin

(14-62)


Sequences


Toxin        


Download         Length: 193 a.a.        Molecular weight: 21913.75 Da        Isoelectric Point: 5.3655

>T222755 WP_003110488.1 NZ_CP086213:4070229-4070807 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGETAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

>T222755 NZ_CP118135:c1753779-1753483 [Pseudomonas chlororaphis]
ATGCATATCATCACCGCCAAACGAATCTGGGAGGCCAAGAACCGCTGGCCACAATCGGCCAATGCTCTGGAAACCTGGTA
CAGAAAAGCCAAAAGCCTCAATCCGGCCGATTTTGCAGCCATCAAGGCGGTATTTCCGGCCACCGACAAAGTGGGGGCGT
TTCACGTCTTCGATATTGGTGGCAACAAGTTACGAATCATCGCCGTGGTGCGTTATGAAGTACGACGTCTCTATATCAGG
CACGTGCTGGACCATCACGAATACGACAAAGGCAGGTGGAAGGAGGAAACCAGATGA

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT222755 WP_003088112.1 NZ_CP086213:4069586-4070140 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp

>AT222755 NZ_CP118135:c1753486-1753085 [Pseudomonas chlororaphis]
ATGAACGTTCTGGTGAAGCAGGCGGCGGATCATTGGCATTTCGTGGCGCCTGTGTTGCGTAAACCCAAGACCGAAGCCGA
TTACGATGCATTGGTCGCCGCGCTGGATGAACTGCTGGATCTCATGGGAGAGGACGAGAACCATCCAGTGACTTCGCTGG
TGGACATCATCGGCGACTGGATCGAAGCCTACGACGAAGAACACCGACCGATGCCGATAGCCAGTGGTGTTGACGTCTTG
CGCTCCCTGATGCGCGAACATGGCCTGACCCAGAGCGATCTGCCAGGCGTGGGCGCGCAGTCGGTGGTTTCCGAAGTGCT
GAGCGGCAAGCGCCAGCTCAACCTGCGGCAGATCCGCTGGCTGGCCGAGCGCTTCGGTGTTTCGGCCGAGGTCTTTATCT
GA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0H2Z8V4


Antitoxin

Source ID Structure

References