Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PP_4151-4152/excise(antitoxin) |
| Location | 2691964..2693006 | Replicon | chromosome |
| Accession | NZ_CP086213 | ||
| Organism | Pseudomonas aeruginosa strain Pa3 | ||
Toxin (Protein)
| Gene name | PP_4152 | Uniprot ID | - |
| Locus tag | LLJ53_RS12890 | Protein ID | WP_003153636.1 |
| Coordinates | 2692431..2693006 (+) | Length | 192 a.a. |
Antitoxin (Protein)
| Gene name | PP_4151 | Uniprot ID | I3TV68 |
| Locus tag | LLJ53_RS12885 | Protein ID | WP_003050245.1 |
| Coordinates | 2691964..2692434 (+) | Length | 157 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LLJ53_RS12850 (LLJ53_12860) | 2687356..2688774 | - | 1419 | WP_006226029.1 | TIGR03752 family integrating conjugative element protein | - |
| LLJ53_RS12855 (LLJ53_12865) | 2688764..2689675 | - | 912 | WP_006226028.1 | TIGR03749 family integrating conjugative element protein | - |
| LLJ53_RS12860 (LLJ53_12870) | 2689672..2690364 | - | 693 | WP_003090182.1 | TIGR03746 family integrating conjugative element protein | - |
| LLJ53_RS12865 (LLJ53_12875) | 2690361..2690759 | - | 399 | WP_003050133.1 | TIGR03750 family conjugal transfer protein | - |
| LLJ53_RS12870 (LLJ53_12880) | 2690771..2691130 | - | 360 | WP_003090173.1 | TIGR03745 family integrating conjugative element membrane protein | - |
| LLJ53_RS12875 (LLJ53_12885) | 2691147..2691380 | - | 234 | WP_023101201.1 | TIGR03758 family integrating conjugative element protein | - |
| LLJ53_RS12880 (LLJ53_12890) | 2691377..2691760 | - | 384 | WP_003090167.1 | RAQPRD family integrative conjugative element protein | - |
| LLJ53_RS12885 (LLJ53_12895) | 2691964..2692434 | + | 471 | WP_003050245.1 | helix-turn-helix domain-containing protein | Antitoxin |
| LLJ53_RS12890 (LLJ53_12900) | 2692431..2693006 | + | 576 | WP_003153636.1 | PIN domain-containing protein | Toxin |
| LLJ53_RS12895 (LLJ53_12905) | 2693024..2693938 | + | 915 | WP_016852809.1 | AAA family ATPase | - |
| LLJ53_RS12900 (LLJ53_12910) | 2693935..2694405 | + | 471 | WP_003090160.1 | type III CBASS phage resistance system CD-NTase-associated protein Cap8 | - |
| LLJ53_RS12905 (LLJ53_12915) | 2694402..2694902 | + | 501 | WP_003090159.1 | type III CBASS phage resistance system CD-NTase-associated protein Cap7 | - |
| LLJ53_RS12910 (LLJ53_12920) | 2694902..2695804 | + | 903 | WP_003090158.1 | CBASS oligonucleotide cyclase | - |
| LLJ53_RS12915 (LLJ53_12925) | 2695843..2696568 | + | 726 | WP_003050273.1 | CBASS effector endonuclease NucC | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | - | 2615027..2738498 | 123471 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 192 a.a. Molecular weight: 21629.78 Da Isoelectric Point: 5.9995
>T222753 WP_003153636.1 NZ_CP086213:2692431-2693006 [Pseudomonas aeruginosa]
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQAIHEEWKRNLLINRPDLTRVQVDRTSDLMDRAIPDGLVEGY
EALVAGLTLPDPNDRHVLAAAIRCGASVIVTFNERDFPNDLLAPYGIESQHPDEFVDNLLDLDAAAVVSAAQRQRAQLKH
PPIDVDRYLEILLRQGLVQTTKVLATYRTIL
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQAIHEEWKRNLLINRPDLTRVQVDRTSDLMDRAIPDGLVEGY
EALVAGLTLPDPNDRHVLAAAIRCGASVIVTFNERDFPNDLLAPYGIESQHPDEFVDNLLDLDAAAVVSAAQRQRAQLKH
PPIDVDRYLEILLRQGLVQTTKVLATYRTIL
Download Length: 576 bp
>T222753 NZ_CP118135:735246-735428 [Pseudomonas chlororaphis]
GTGGACAGTCGGTATTTGATCGGCCAAATCGTCGCAGACGGTTGGTATCTAGTCAGGGTCAGGGGCAGTCACCACCATTT
CAAGCATCCCCATAAACCGGGGCTGGTGACCGTTCCCCATCCCAAAAAGGACCTGCTGAGAAAAACCGCCATCAGCATTC
TGAAACAGGCGCTGCTCATGTGA
GTGGACAGTCGGTATTTGATCGGCCAAATCGTCGCAGACGGTTGGTATCTAGTCAGGGTCAGGGGCAGTCACCACCATTT
CAAGCATCCCCATAAACCGGGGCTGGTGACCGTTCCCCATCCCAAAAAGGACCTGCTGAGAAAAACCGCCATCAGCATTC
TGAAACAGGCGCTGCTCATGTGA
Antitoxin
Download Length: 157 a.a. Molecular weight: 17245.62 Da Isoelectric Point: 6.3803
>AT222753 WP_003050245.1 NZ_CP086213:2691964-2692434 [Pseudomonas aeruginosa]
MTTATAQSKMTLPAAGEVKAAVQGQRALAAYLATQFETQHIQIFDDHKQAHQVELPTSALRLLVDILAELADGNAVKVVP
VHAELTTQEAADLLNVSRPHFVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELAQQSQELGMGYE
MTTATAQSKMTLPAAGEVKAAVQGQRALAAYLATQFETQHIQIFDDHKQAHQVELPTSALRLLVDILAELADGNAVKVVP
VHAELTTQEAADLLNVSRPHFVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELAQQSQELGMGYE
Download Length: 471 bp
>AT222753 NZ_CP118135:735461-735868 [Pseudomonas chlororaphis]
ATGCTTTACCCGATTGCAATTTCAATGGGCGATGACGAACACGCCTGGGGGGTGGAAGTCCCCGACATTCCTGGCTGTTT
CTCGGCCGGCGACGACCTCGACGACGCCATGGCCATGGCCCGCGAAGCCATCGAAGGGCACTTCGAGATTCTCGCTGAAG
ACGGTGCCCCCATCCCGCACGCCAACAAGGTCACCCTGCACGCCGCCAACCCCCGGTACGCAGGCTGCACCTGGGCGCTG
ATCGACATCGATGTCACCAAGTACCTGGGCAAGGCGCAGAAGCTCAACATCACCCTGCCCGGCTACTTGCTGAACCGCAT
CGACGAATACGTGCTGCATCACCCGGAAGCCAAGAGCCGCTCGGGTTTTCTCGCTTCGGCTGCACTGAAGGTATTGCAGC
AAGACTGA
ATGCTTTACCCGATTGCAATTTCAATGGGCGATGACGAACACGCCTGGGGGGTGGAAGTCCCCGACATTCCTGGCTGTTT
CTCGGCCGGCGACGACCTCGACGACGCCATGGCCATGGCCCGCGAAGCCATCGAAGGGCACTTCGAGATTCTCGCTGAAG
ACGGTGCCCCCATCCCGCACGCCAACAAGGTCACCCTGCACGCCGCCAACCCCCGGTACGCAGGCTGCACCTGGGCGCTG
ATCGACATCGATGTCACCAAGTACCTGGGCAAGGCGCAGAAGCTCAACATCACCCTGCCCGGCTACTTGCTGAACCGCAT
CGACGAATACGTGCTGCATCACCCGGAAGCCAAGAGCCGCTCGGGTTTTCTCGCTTCGGCTGCACTGAAGGTATTGCAGC
AAGACTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|