Detailed information of TA system TA222749

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 3431421..3431890
• Replicon: chromosome
• Accession: NZ_CP086206
• Organism: Pseudomonas sp. HN8-3

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A5D3G6G1
• Locus tag: LJX92_RS14890
• Protein ID: WP_032880728.1
• Coordinates: 3431421..3431696 (-)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: LJX92_RS14895
• Protein ID: WP_228308503.1
• Coordinates: 3431696..3431890 (-)
• Length: 65 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LJX92_RS14865 (LJX92_14885)	3426432..3427220	+	789	WP_228308498.1	helix-turn-helix transcriptional regulator	-
LJX92_RS14870 (LJX92_14890)	3427313..3427744	+	432	WP_228308499.1	hypothetical protein	-
LJX92_RS14875 (LJX92_14895)	3427774..3428892	-	1119	WP_228308500.1	carboxylate-amine ligase	-
LJX92_RS14880 (LJX92_14900)	3428899..3429843	-	945	WP_228308501.1	class I SAM-dependent methyltransferase	-
LJX92_RS14885 (LJX92_14905)	3429855..3431234	-	1380	WP_228308502.1	iron-containing redox enzyme family protein	-
LJX92_RS14890 (LJX92_14910)	3431421..3431696	-	276	WP_032880728.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LJX92_RS14895 (LJX92_14915)	3431696..3431890	-	195	WP_228308503.1	stability determinant	Antitoxin
LJX92_RS14900 (LJX92_14920)	3432039..3433781	-	1743	WP_003192009.1	ABC transporter substrate-binding protein	-
LJX92_RS14905 (LJX92_14925)	3433814..3434086	-	273	WP_003192011.1	DUF2160 domain-containing protein	-
LJX92_RS14910 (LJX92_14930)	3434098..3434898	-	801	WP_003232361.1	carbohydrate ABC transporter permease	-
LJX92_RS14915 (LJX92_14935)	3434909..3435775	-	867	WP_005789024.1	sugar ABC transporter permease	-
LJX92_RS14920 (LJX92_14940)	3435772..3436869	-	1098	WP_148853871.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-88)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10216.89 Da
• Isoelectric Point: 6.2138

>T222749 WP_032880728.1 NZ_CP086206:c3431696-3431421 [Pseudomonas sp. HN8-3]
MLAVVWLDEAIGDLIDIVTFIAAENPGAARRIKTRLEGAPLPLAEHPYLYPCGRVPGTREVVVHPNYVLVYRVTAERIEI
VNVLHARQEYP

Nucleotide

• Length: 276 bp

>T222749 NZ_CP118134:c1826921-1826607 [Pseudomonas synxantha]
ATGATTTTCATAGAGACGTCAGTCTTCACCCGTCGCGTTAAAGAATTGATCGACGAGGATGCCTACATGGCTCTTCAGAA
CGTGCTGGTAGTCAACCCTTCTGCTGGCGATGTGATTGAGGGTACGGGTGGAGTTCGCAAGATACGAGTAGCAGCCAAAG
GCCATGGCAAACGAGGCGGGGCGCGGGTGATCTATTACCATTTCGTCTCGGCATCACAGATTGTTTTACTGATGATCTAT
CCCAAAAATGAACAGCAGGACTTGACTGCCGTAGAGCGCAAGTCACTGAAGGCTGCGATTGAGCACTGGAGATAG

Antitoxin

Protein

• Length: 65 a.a.
• Molecular weight: 7098.12 Da
• Isoelectric Point: 5.0509

>AT222749 WP_228308503.1 NZ_CP086206:c3431890-3431696 [Pseudomonas sp. HN8-3]
MGVPLSPIVSEFETEEQASSHDLWFRKKVEKSLANPGPGVPHDEVMARVEAIILKAELEQRAKA

Nucleotide

• Length: 195 bp

>AT222749 NZ_CP118134:c1826604-1826317 [Pseudomonas synxantha]
ATGAGCAGATTTTTTGATGAACTGATGGAAAGCGTTCAAGAGATGAACGAGATCCTGCGCGGAGAACGCGAACCTTCTCG
TGAGTTCCATGTTGATTCAATGCGAGTCAAAGAGATCCGTAAGGCGACAGGGCTAACCCAGGCTAAATTCGCAGCGCTGA
TTGATGTGCAACTTGGCACGTTACGGAACTGGGAGCAGGGTCGTCGTGAGCCTACCGGACCAGCAAAGGCATTGTTGAAA
GCTATCCATAATGACCCAGTCCATGTACTGAATGCGTTGGCTAGCTAA

Structures

Toxin

• AlphaFold DB: A0A5D3G6G1