Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3788332..3788984 Replicon chromosome
Accession NZ_CP086203
Organism Morganella morganii strain MMAS2018

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag LLY23_RS18425 Protein ID WP_080939504.1
Coordinates 3788332..3788679 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID -
Locus tag LLY23_RS18430 Protein ID WP_046024792.1
Coordinates 3788679..3788984 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LLY23_RS18385 (LLY23_18410) 3783696..3784319 - 624 WP_004236525.1 thiol:disulfide interchange protein DsbA -
LLY23_RS18390 (LLY23_18415) 3784338..3785333 - 996 WP_004236526.1 serine/threonine protein kinase -
LLY23_RS18395 (LLY23_18420) 3785333..3785602 - 270 WP_004240741.1 YihD family protein -
LLY23_RS18400 (LLY23_18425) 3785823..3786395 + 573 Protein_3577 molybdenum cofactor guanylyltransferase MobA -
LLY23_RS18405 (LLY23_18430) 3786402..3786920 + 519 WP_228342987.1 molybdopterin-guanine dinucleotide biosynthesis protein MobB -
LLY23_RS18410 (LLY23_18435) 3787130..3787432 + 303 WP_004236529.1 HdeA/HdeB family chaperone -
LLY23_RS18415 (LLY23_18440) 3787560..3788081 + 522 WP_046024836.1 isopentenyl-diphosphate Delta-isomerase -
LLY23_RS18420 (LLY23_18445) 3788078..3788218 + 141 WP_004236531.1 hypothetical protein -
LLY23_RS18425 (LLY23_18450) 3788332..3788679 - 348 WP_080939504.1 GNAT family N-acetyltransferase Toxin
LLY23_RS18430 (LLY23_18455) 3788679..3788984 - 306 WP_046024792.1 DUF1778 domain-containing protein Antitoxin
LLY23_RS18435 (LLY23_18460) 3789116..3790468 - 1353 WP_046024838.1 glutathione-disulfide reductase -
LLY23_RS18440 (LLY23_18465) 3790538..3791380 - 843 WP_004236535.1 23S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ -
LLY23_RS18445 (LLY23_18470) 3791570..3791959 + 390 WP_064483574.1 DUF1090 domain-containing protein -
LLY23_RS18450 (LLY23_18475) 3792371..3793363 + 993 WP_049242212.1 inner membrane protein YhjD -
LLY23_RS18455 (LLY23_18480) 3793471..3793677 + 207 WP_004236540.1 4-oxalocrotonate tautomerase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(28-90)

Antitoxin

Vibrio phage ICP1, Orf50

(17-91)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12424.59 Da        Isoelectric Point: 10.3028

>T222744 WP_080939504.1 NZ_CP086203:c3788679-3788332 [Morganella morganii]
MAYYALSTGVITCSQAAGRFRRNMPPEIPVILPGRLAVDESVKGRGIGRGLIKDAALRVLQAAGIVGIRGIVVRALSDNA
RRFYEHTGFIPSPADPMLLMITLRDLQLATGIYSE

Download         Length: 348 bp

>T222744 NZ_CP118097:c892188-891343 [Streptococcus dysgalactiae subsp. equisimilis]
ATGAACAAAGCTAAATTAACAGCACTCTGTCATAAAATATCAAAGAATACTGGTTTAACCTTTAATTCCGTGATGACCTA
TTACTTCCTAGAAGTCATTTTGAAAAAATTAAGTCAAAGTTCTTATTCAAATCACTATATCTTCAAAGGAGGATTCCTAC
TGTCGAATGTCATCGGAGTTGAATCTCGTAGCACTGTTGATATTGACTTTTTATTCCATCAAATAACACTCTCAGAAGAA
ACTGTTAAACAGCAACTCAAGGAAATTTTAGCAGATTCCGAAGAAGGTATATCTTTTGTGATTCAATCAATCACAACTAT
TAAAGAAAGTGATGACTATGGTGGCTATCGAGCAACAATTTCGTGCCAACTTGAGAATATTAAACAAGTTATCCATTTGG
ATATTGCGACAGGTGATGTTGTAACTCCTCAGCCGATAACATACGACTATAAAGCTATTTTTGATGAAGACAATTTTCCA
ATCATTGCTTATACAATTGAAACAATTCTAGCTGAAAAACTCCAAACCATCTATTCACGAAACTTCTTGAACAGCAGAAG
CAAAGACTTTTACGATGTTTATATTCTTTCAAAATTGAAGAAAAAAGATATTGATTTCAATCAGTTAAAAAATGCTTGCC
AAAGAACTTTTTCCTATCGCGAAACTGAGCTCGATTTCGAAAAAATTATTGAACTACTCGAGAGATTCAAATCTGATCCT
ACTCAGAATCAACAATGGCAAAATTATTCAAAAAAATATAGTTATACAAAAGGAATTTCACTTGCAAATGTGCTTGATGA
GATGATTAGTCTTATTACAATTATTATTTCTACTGACTCTGATTAA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11158.62 Da        Isoelectric Point: 6.6439

>AT222744 WP_046024792.1 NZ_CP086203:c3788984-3788679 [Morganella morganii]
MTKHIDEQHPVSGVNITRSTLNLRIKPEDKILIDRAAHAAGKNRTEFVLEAARRAAEETLADLRVIDVSTDVYQQFITRL
DMAPQSGEALHGHLSSVTITG

Download         Length: 306 bp

>AT222744 NZ_CP118097:c892775-892185 [Streptococcus dysgalactiae subsp. equisimilis]
ATGTCAAAAAAAGAGATTCTACTCGATTTTATAGAAAAGAACAATGGCATTGTCACAAACAAAGATTGTAAAGCACTAGG
TATTCCAACAATATATCTGACAAGACTAGAGAAAGAAGGCATTATCTTCCGAGTTGAAAAAGGTATTTTCCTAACCCAAA
ACGGAGACTATGATGAATACTACTTCTTTCAATATCGTTTTCCTAAGGCTATTTTCTCTTATATTTCGGCACTGTATCTA
CAACAGTTTACAGATGAAATTCCACAATATTTTGATGTGACAGTTCCTAGAGGCTACCGCTTTAATACTCCTCCAGCTAA
TCTAAACATTCACTTTGTCTCTAAAGAATACAGCGAGCTGGGAATGACTACTGTACCTACTCCTATGGGAAACAACGTAA
GGGTATATGATTTTGAACGTATTATTTGTGATTTTGTAATACATCGAGAAAAGATTGATTCCGAACTCTTTGTCAAGACA
CTTCAATCTTATGGGAACTATCCTAAAAAAAATCTAGCAAAACTCTATGAATATGCGACAAAAATGAATACTTTAGAAAA
AGTTAAACAAACTCTGGAGGTTCTAATATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References