Detailed information of TA system TA222742

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 937310..937802
• Replicon: chromosome
• Accession: NZ_CP086203
• Organism: Morganella morganii strain MMAS2018

Toxin (Protein)

• Gene name: relE
• Uniprot ID: J7TMG3
• Locus tag: LLY23_RS04270
• Protein ID: WP_004237651.1
• Coordinates: 937575..937802 (+)
• Length: 76 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: LLY23_RS04265
• Protein ID: WP_064483260.1
• Coordinates: 937310..937591 (+)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LLY23_RS04260 (LLY23_04265)	932476..937110	+	4635	WP_064483259.1	hemagglutinin repeat-containing protein	-
LLY23_RS04265 (LLY23_04270)	937310..937591	+	282	WP_064483260.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
LLY23_RS04270 (LLY23_04275)	937575..937802	+	228	WP_004237651.1	type II toxin-antitoxin system YafQ family toxin	Toxin
LLY23_RS04275 (LLY23_04280)	938105..939589	+	1485	WP_004237652.1	C69 family dipeptidase	-
LLY23_RS04280 (LLY23_04285)	939655..940107	-	453	WP_004237653.1	NfeD family protein	-
LLY23_RS04285 (LLY23_04290)	940104..941042	-	939	WP_004237654.1	SPFH domain-containing protein	-
LLY23_RS04290 (LLY23_04295)	941098..941955	-	858	WP_015422944.1	co-chaperone YbbN	-
LLY23_RS04295 (LLY23_04300)	942015..942800	-	786	WP_004241009.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (3-74)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-81)

Sequences

Toxin

Protein

• Length: 76 a.a.
• Molecular weight: 9069.63 Da
• Isoelectric Point: 9.9416

>T222742 WP_004237651.1 NZ_CP086203:937575-937802 [Morganella morganii]
MARTIERSSQFKKDYKREVKGIYRMMLNDSLQNILNILVNDLPIPEKYADHPLKGNWRTFRDCHLYPDLILIYKK

Nucleotide

• Length: 228 bp

>T222742 NZ_CP118095:1192720-1192998 [Aerococcus christensenii]
ATGTTGAAAGTTGAACAATCAAGCGAATTTATTAAGCACTTAAAAAAGTACGTAAAGAAACATTACGATATGGAGAAGTT
GCATCGAGCCGTTCAAGCTTTAGTAAAACAAGATGAACAATTGCTCAAAACAAAATATAAAGATCATTCTTTAAACGGTC
AACTTCAAGGTCTGAGAGAATTACACATCGAAGGAGATTGGCTACTCATCTATAAAATAGATCACGGAAAGCTTATTCTA
TACTTACTAGATACAGGTTCACACGATGATTTATTCTAA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10454.14 Da
• Isoelectric Point: 5.8765

>AT222742 WP_064483260.1 NZ_CP086203:937310-937591 [Morganella morganii]
MSKVEYVRAKIDPKLKAEAIETLESMGLTVSDAIRMLMIQIVEQKAMPFCVKSTQYRHAARTRASIEELECGKGKKFDSI
SDLMADLQDGKDD

Nucleotide

• Length: 282 bp

>AT222742 NZ_CP118095:1192473-1192733 [Aerococcus christensenii]
ATGACAAATTCAACTGTTACTGTACGCATGGATTCTAAACTAAAAGAAGATACAAGAGAAATTCTCGATTCATTAGGCTT
GGATTTTTCAGCAGCTATTAATATATATTTTAAACAAATCAACATGAAACAAGGTTTGCCTTTTGAGATTAAATGTTCGG
GGTTACAACAAACCCTTGACGATATAAAAAACGGAAACAGCATGACATTTGAAAACGAAAAAGATTGGTGGAAATGGGTA
ACAGAAAATGTTGAAAGTTGA

Structures

Toxin

• AlphaFold DB: J7TMG3