Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 893292..893918 Replicon chromosome
Accession NZ_CP086203
Organism Morganella morganii strain MMAS2018

Toxin (Protein)


Gene name Hha Uniprot ID A0A0A2RCL2
Locus tag LLY23_RS04125 Protein ID WP_024474604.1
Coordinates 893292..893495 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J7U1S9
Locus tag LLY23_RS04130 Protein ID WP_004236473.1
Coordinates 893559..893918 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LLY23_RS04105 (LLY23_04110) 889849..890187 + 339 WP_004236467.1 P-II family nitrogen regulator -
LLY23_RS04110 (LLY23_04115) 890207..891496 + 1290 WP_064483483.1 ammonium transporter AmtB -
LLY23_RS04115 (LLY23_04120) 891556..892419 - 864 WP_032097922.1 acyl-CoA thioesterase II -
LLY23_RS04125 (LLY23_04130) 893292..893495 - 204 WP_024474604.1 HHA domain-containing protein Toxin
LLY23_RS04130 (LLY23_04135) 893559..893918 - 360 WP_004236473.1 Hha toxicity modulator TomB Antitoxin
LLY23_RS04135 (LLY23_04140) 894481..897657 - 3177 WP_015422956.1 efflux RND transporter permease subunit -
LLY23_RS04140 (LLY23_04145) 897672..898868 - 1197 WP_024474606.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-113)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8073.39 Da        Isoelectric Point: 6.9770

>T222741 WP_024474604.1 NZ_CP086203:c893495-893292 [Morganella morganii]
MTKLDYLMRLRKCTSIETLERVIEKNKYELTDDELEVFYSAADHRLAELTMNKLYDKIPASVWKFVR

Download         Length: 204 bp

>T222741 NZ_CP118095:c1172596-1172330 [Aerococcus christensenii]
ATGACCTATAGGTTAGTTTTGAGTAAGCGAGCACGAAAACAATTAAAAAAGATGGACAGGCACGTTGCTTACATGTTAGC
CAAATACATGAAGAAACAGCTTGATGGATTGAGTGATCCACGAATTTATGGAAAGGCACTTGTTGGCGATAAGACAGGCT
TATGGCGGTATCGCCTTGGTGATTATCGAGTGATTTGTGAGATTAAAGATGAGCAGCTTGTCATCTTAGCGCTAGAAATA
GGCCATCGAAAATTAATATACAAGTAG

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13826.54 Da        Isoelectric Point: 4.2870

>AT222741 WP_004236473.1 NZ_CP086203:c893918-893559 [Morganella morganii]
MDEYSPRNYDIAVLKYLCDELCREGTQTLIRSNNYWVNDLASDSNLKLNELLGYIADVAWSFKIKHTQNKDLISFVDEYI
DETYALFGQMEVSFNDVEEWKKMASLVSSMLTSEGHLVH

Download         Length: 360 bp

>AT222741 NZ_CP118095:c1172813-1172586 [Aerococcus christensenii]
ATGGCAGTTGTGTCTTTACGATTAAATGAAACAGAAGAAAGAACTTTTCGAGATTACGCAAAGCTGACAGGGAAAACTTT
ATCAGAGTTATTTAAGGAATCACTAACACAAGAAATTGAGGATAAACTAGATTATCAAGTTGGCCTAGAAGCTTTGGAAG
AGTTTCAGCTTGATCCTACAACTTATGATATTGATGAAGTTATTGAGGAGTTAGGGCATGACCTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A2RCL2

Antitoxin

Source ID Structure
AlphaFold DB J7U1S9

References