Detailed information of TA system TA222739

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 3859869..3860526
• Replicon: chromosome
• Accession: NZ_CP086201
• Organism: Enterobacter roggenkampii strain F1057

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: LL005_RS18205
• Protein ID: WP_032653292.1
• Coordinates: 3859869..3860279 (-)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: W7NX65
• Locus tag: LL005_RS18210
• Protein ID: WP_006178375.1
• Coordinates: 3860260..3860526 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LL005_RS18185 (LL005_18215)	3855862..3857595	-	1734	WP_063616450.1	single-stranded-DNA-specific exonuclease RecJ	-
LL005_RS18190 (LL005_18220)	3857601..3858314	-	714	WP_233396060.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
LL005_RS18195 (LL005_18225)	3858343..3859239	-	897	WP_008499709.1	site-specific tyrosine recombinase XerD	-
LL005_RS18200 (LL005_18230)	3859341..3859862	+	522	WP_023309099.1	flavodoxin FldB	-
LL005_RS18205 (LL005_18235)	3859869..3860279	-	411	WP_032653292.1	protein YgfX	Toxin
LL005_RS18210 (LL005_18240)	3860260..3860526	-	267	WP_006178375.1	FAD assembly factor SdhE	Antitoxin
LL005_RS18215 (LL005_18245)	3860821..3861801	+	981	WP_032653295.1	tRNA-modifying protein YgfZ	-
LL005_RS18220 (LL005_18250)	3861886..3862545	-	660	WP_021242052.1	hemolysin III family protein	-
LL005_RS18225 (LL005_18255)	3862811..3863542	+	732	WP_233396665.1	MurR/RpiR family transcriptional regulator	-
LL005_RS18230 (LL005_18260)	3863659..3865092	+	1434	WP_023294510.1	6-phospho-beta-glucosidase BglA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 16069.03 Da
• Isoelectric Point: 10.9468

>T222739 WP_032653292.1 NZ_CP086201:c3860279-3859869 [Enterobacter roggenkampii]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLNCGMMLRLRKADGGRCQHLWLAADSMDAAEWRDLRRMLLQQTTQG

Nucleotide

• Length: 411 bp

>T222739 NZ_CP118090:974743-975048 [Lactobacillus gasseri]
ATGGCTCAAATTAACTACACTCCTCAATTTAAGCGAGATTATAAGAAGCTTAAAAGAAAACATTATGATTTGAATAAATT
AAAAAATGTCATTCAATTACTTATTGACGAAAAATTTAAAATTCTTGTTGATAAATATGATGACCATCAACTAAAAGGTT
CTTTAAGGTCACTACGTGCATTACATGTTGAGCATAATAAAGCTGGTAATTGGATTTTAGTTTATAAAATTCATAGCGGC
AATTTAGAACTGTTAACCATCGACTTGGTTTCTACTGGTTCCCACGATCATACTTATAGAACATAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10569.05 Da
• Isoelectric Point: 5.1340

>AT222739 WP_006178375.1 NZ_CP086201:c3860526-3860260 [Enterobacter roggenkampii]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT222739 NZ_CP118090:974468-974743 [Lactobacillus gasseri]
ATGACAACTACCGTAAGTTTAAGATTACCAGAAGATTTAAAGAAACAAGCAACAGATGTATTCAACGAATACGGTCTCGA
TTGGTCATCTGCAATGCGAATGATCTTAACTCAAGTCGTAAGTGAAAATGCAATTCCTGTTAATTTACATAGATATTCTG
AAATTTCTCCTTCGATGAAATCAAATATTGATAGGTCACTTCAAGAATACAAAGCAGGAAATTATAAAACCACAAACTCA
GTAAAAGAGCTATTTGAGGAGTTAGATAAAGACTAA

Structures

Antitoxin

• AlphaFold DB: W7NX65