Detailed information of TA system TA222738

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 3603994..3604731
• Replicon: chromosome
• Accession: NZ_CP086201
• Organism: Enterobacter roggenkampii strain F1057

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: LL005_RS17005
• Protein ID: WP_105551926.1
• Coordinates: 3604351..3604731 (+)
• Length: 127 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: LL005_RS17000
• Protein ID: WP_105551925.1
• Coordinates: 3603994..3604320 (+)
• Length: 109 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LL005_RS16965 (LL005_16995)	3599221..3599568	-	348	WP_233396003.1	hypothetical protein	-
LL005_RS16970 (LL005_17000)	3600037..3600912	+	876	WP_233396004.1	GTPase family protein	-
LL005_RS16975 (LL005_17005)	3601125..3601826	+	702	WP_200557869.1	WYL domain-containing protein	-
LL005_RS16980 (LL005_17010)	3601832..3602461	+	630	WP_105551922.1	hypothetical protein	-
LL005_RS16985 (LL005_17015)	3602515..3602958	+	444	WP_038251594.1	IrmA family protein	-
LL005_RS16990 (LL005_17020)	3603083..3603502	+	420	WP_105551923.1	antirestriction protein	-
LL005_RS16995 (LL005_17025)	3603516..3603983	+	468	WP_105551924.1	DNA repair protein RadC	-
LL005_RS17000 (LL005_17030)	3603994..3604320	+	327	WP_105551925.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
LL005_RS17005 (LL005_17035)	3604351..3604731	+	381	WP_105551926.1	TA system toxin CbtA family protein	Toxin
LL005_RS17010 (LL005_17040)	3604728..3604937	+	210	WP_105551927.1	DUF5983 family protein	-
LL005_RS17015 (LL005_17045)	3605208..3606254	-	1047	WP_233396005.1	methylated-DNA--[protein]-cysteine S-methyltransferase	-
LL005_RS17020 (LL005_17050)	3606238..3607014	-	777	WP_233396006.1	isocitrate lyase/phosphoenolpyruvate mutase family protein	-
LL005_RS17025 (LL005_17055)	3607172..3607369	-	198	Protein_3327	nucleotidyltransferase domain-containing protein	-
LL005_RS17030 (LL005_17060)	3607757..3608113	+	357	WP_008502540.1	hypothetical protein	-
LL005_RS17035 (LL005_17065)	3608219..3608779	+	561	WP_233396007.1	YceI family protein	-
LL005_RS17040 (LL005_17070)	3608771..3609562	-	792	WP_233396008.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3584955..3607402	22447

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-109)

Antitoxin

• Antitoxin CbeA (4-103)

Sequences

Toxin

Protein

• Length: 127 a.a.
• Molecular weight: 13964.81 Da
• Isoelectric Point: 6.8592

>T222738 WP_105551926.1 NZ_CP086201:3604351-3604731 [Enterobacter roggenkampii]
MQTLSLSEPRAAEPCPSPVQVWQLLLIHLLDKHYGLTLNDTPFGDDSVIQAHINARISLCDAVNFIVQRYELVRTDNSSF
NLSDRSSLIGAIDILHARRATGLIVRSGYSNITRITTGRYQGGEAQ

Nucleotide

• Length: 381 bp

>T222738 NZ_CP118088:974734-975039 [Lactobacillus gasseri]
ATGGCTCAAATTAACTACACTCCTCAATTTAAGCGAGATTATAAGAAGCTTAAAAGAAAACATTATGATTTGAATAAATT
AAAAAATGTCATTCAATTACTTATTGACGAAAAATTTAAAATTCTTGTTGATAAATATGATGACCATCAACTAAAAGGTT
CTTTAAGGTCACTACGTGCATTACATGTTGAGCATAATAAAGCTGGTAATTGGATTTTAGTTTATAAAATTCATAGCGGC
AATTTAGAACTGTTAACCATCGACTTGGTTTCTACTGGTTCCCACGATCATACTTATAGAACATAA

Antitoxin

Protein

• Length: 109 a.a.
• Molecular weight: 12067.55 Da
• Isoelectric Point: 5.9514

>AT222738 WP_105551925.1 NZ_CP086201:3603994-3604320 [Enterobacter roggenkampii]
MHSQQWGLTCSKTPSFDARLVQEGNRLHFLADRAGFTGDFSDDEALRLDQAFPLIMKQLEQMLTTGELNPRHQQRVTLNH
IGLTCEADTLGSHGYVYIAIYPSSTVTG

Nucleotide

• Length: 327 bp

>AT222738 NZ_CP118088:974459-974734 [Lactobacillus gasseri]
ATGACAACTACCGTAAGTTTAAGATTACCAGAAGATTTAAAGAAACAAGCAACAGATGTATTCAACGAATACGGTCTCGA
TTGGTCATCTGCAATGCGAATGATCTTAACTCAAGTCGTAAGTGAAAATGCAATTCCTGTTAATTTACATAGATATTCTG
AAATTTCTCCTTCGATGAAATCAAATATTGATAGGTCACTTCAAGAATACAAAGCAGGAAATTATAAAACCACAAACTCA
GTAAAAGAGCTATTTGAGGAGTTAGATAAAGACTAA