Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 1663574..1664371 Replicon chromosome
Accession NZ_CP086201
Organism Enterobacter roggenkampii strain F1057

Toxin (Protein)


Gene name KacT Uniprot ID A0A155TD66
Locus tag LL005_RS07730 Protein ID WP_032651255.1
Coordinates 1663850..1664371 (+) Length 174 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID W7PG43
Locus tag LL005_RS07725 Protein ID WP_008499829.1
Coordinates 1663574..1663843 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LL005_RS07695 (LL005_07710) 1659197..1659640 - 444 WP_008499834.1 helix-turn-helix domain-containing protein -
LL005_RS07700 (LL005_07715) 1659793..1661034 + 1242 WP_233396469.1 bifunctional glucose-1-phosphatase/inositol phosphatase -
LL005_RS07705 (LL005_07720) 1661070..1661297 - 228 WP_008499832.1 YccJ family protein -
LL005_RS07710 (LL005_07725) 1661318..1661914 - 597 WP_008499831.1 NAD(P)H:quinone oxidoreductase -
LL005_RS07715 (LL005_07730) 1662306..1662476 + 171 WP_013097201.1 general stress protein -
LL005_RS07720 (LL005_07735) 1662595..1663512 + 918 WP_025912980.1 DMT family transporter -
LL005_RS07725 (LL005_07740) 1663574..1663843 + 270 WP_008499829.1 DUF1778 domain-containing protein Antitoxin
LL005_RS07730 (LL005_07745) 1663850..1664371 + 522 WP_032651255.1 GNAT family N-acetyltransferase Toxin
LL005_RS07735 (LL005_07750) 1664445..1665767 - 1323 WP_104948907.1 pyrimidine utilization transport protein G -
LL005_RS07740 (LL005_07755) 1665789..1666283 - 495 WP_023292823.1 pyrimidine utilization flavin reductase protein F -
LL005_RS07745 (LL005_07760) 1666293..1666883 - 591 WP_008499824.1 malonic semialdehyde reductase -
LL005_RS07750 (LL005_07765) 1666893..1667693 - 801 WP_233396470.1 pyrimidine utilization protein D -
LL005_RS07755 (LL005_07770) 1667701..1668087 - 387 WP_008499822.1 pyrimidine utilization protein C -
LL005_RS07760 (LL005_07775) 1668099..1668788 - 690 WP_047745127.1 pyrimidine utilization protein B -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 174 a.a.        Molecular weight: 19714.46 Da        Isoelectric Point: 7.0497

>T222729 WP_032651255.1 NZ_CP086201:1663850-1664371 [Enterobacter roggenkampii]
VDNLTIEMFSEGKDYDFRDFDCGEPSLNVFLTEHLVRQHNGRILRGYLLKDRDGPRVLGYYTLSGSCFEKAMLPSKTQQR
RIPYSNVPSVTLGRLAIHKDLQGLEWGTTLVTHAMRVVYLASQAVGVHGIFVDALNDQAKQFYLKQGFIPLTDENSHSLF
FPTKSIERLFEQA

Download         Length: 522 bp

>T222729 NZ_CP118079:c250062-249727 [Streptococcus agalactiae]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCCCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAATGACATAGAAAAACTTGAAGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAGAAATCAGCAATTATCACAGTACTAGAGGTTACACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAAGAGGAAGAGAATAGCGTTGTCATTGATTACTTGCTTCCTACTCGAAGCGACTATAT
GAAATTGTTTAAATAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10262.72 Da        Isoelectric Point: 5.8836

>AT222729 WP_008499829.1 NZ_CP086201:1663574-1663843 [Enterobacter roggenkampii]
MPALKKQRIDLRLTDEDKTMIEEAAAMTNQTITQFMVNSASERAAEVIEQHRRLVLNEASWNAVMDAIDNPPEPNERLKR
AAKRLRNME

Download         Length: 270 bp

>AT222729 NZ_CP118079:c250339-250052 [Streptococcus agalactiae]
ATGGTTACAGTAGAAAAAAATAGAGCTGTCACATTCCAAGCTAACAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCCGAAATCAGCAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A155TD66

Antitoxin

Source ID Structure
AlphaFold DB W7PG43

References