Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1071003..1071623 Replicon chromosome
Accession NZ_CP086201
Organism Enterobacter roggenkampii strain F1057

Toxin (Protein)


Gene name Hha Uniprot ID A0A1H8SI38
Locus tag LL005_RS04960 Protein ID WP_008499287.1
Coordinates 1071003..1071221 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V3PBI9
Locus tag LL005_RS04965 Protein ID WP_008499288.1
Coordinates 1071249..1071623 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LL005_RS04930 (LL005_04945) 1067016..1067276 + 261 WP_006176933.1 type B 50S ribosomal protein L31 -
LL005_RS04935 (LL005_04950) 1067279..1067419 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
LL005_RS04940 (LL005_04955) 1067416..1068126 - 711 WP_032656573.1 GNAT family protein -
LL005_RS04945 (LL005_04960) 1068228..1069688 + 1461 WP_233396354.1 PLP-dependent aminotransferase family protein -
LL005_RS04950 (LL005_04965) 1069660..1070127 - 468 WP_008499285.1 YlaC family protein -
LL005_RS04955 (LL005_04970) 1070245..1070796 - 552 WP_008499286.1 maltose O-acetyltransferase -
LL005_RS04960 (LL005_04975) 1071003..1071221 - 219 WP_008499287.1 HHA domain-containing protein Toxin
LL005_RS04965 (LL005_04980) 1071249..1071623 - 375 WP_008499288.1 Hha toxicity modulator TomB Antitoxin
LL005_RS04970 (LL005_04985) 1072133..1075279 - 3147 WP_008499289.1 multidrug efflux RND transporter permease subunit AcrB -
LL005_RS04975 (LL005_04990) 1075302..1076495 - 1194 WP_021241633.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8612.00 Da        Isoelectric Point: 8.9008

>T222728 WP_008499287.1 NZ_CP086201:c1071221-1071003 [Enterobacter roggenkampii]
MSDKPLTKIDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFVR

Download         Length: 219 bp

>T222728 NZ_CP118078:c1497945-1497580 [Streptococcus anginosus]
GTGCATAATATCTATTTTTACAAGGATAAAAACGGTAATGAGCCTATTTTAGATTATATGCGAGAGCTTGCCAGTAAAAA
GGGAAAAGATAGTAGAATTAAACTCAATAAAATCAATGATTATATTGAGTTGTTAAGTCAACACGGAACACGCACAGGCG
AGCCATATATTAAGCATTTAGATGCTGAAATTTGGGAACTAAGACCATTAAGGGATAGAATTTTATTTGTTGCATGGATT
GATGGTAGCTTTGTTTTACTCCATCATTTCATGAAAAAGACACAGAAAACACCAAAAAGAGAGATTGAACAAGCTAAACG
TGAGTTAGCAGACTTAAAAGAAAGAGGTTTAGACAATGAAAAATAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14481.28 Da        Isoelectric Point: 4.8886

>AT222728 WP_008499288.1 NZ_CP086201:c1071623-1071249 [Enterobacter roggenkampii]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNVSRANPVSLSC

Download         Length: 375 bp

>AT222728 NZ_CP118078:c1497590-1497297 [Streptococcus anginosus]
ATGAAAAATAGTGCAATTGGTAGTAACTGGAAAGATGTAAGAGCTGAGTTATTCAGCAAAGAAGAAATTTTAGAAAGTGA
TATGCGCGTGGCTATCATGAGTGAGCTTATCGAGGCTAGGAATGAAAGGGGCATTAGTCAAAAAAAACTAGAGGAGCTGA
GTGGCGTTAGTCAGCCAGTCATAGCTAGAATGGAGACAGGAAAAACAAGCCCACAGCTTGATACAGTATTAAAGGTTTTG
GCAAGTCTTGATAAGACTTTAGCGGTTGTACCACTAGAGCGTGAACAAGTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8SI38

Antitoxin

Source ID Structure
AlphaFold DB V3PBI9

References