Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 150978..151585 Replicon chromosome
Accession NZ_CP086201
Organism Enterobacter roggenkampii strain F1057

Toxin (Protein)


Gene name hicA Uniprot ID A0A7H0N5B9
Locus tag LL005_RS00685 Protein ID WP_071993467.1
Coordinates 150978..151163 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A155E9Y3
Locus tag LL005_RS00690 Protein ID WP_032675741.1
Coordinates 151178..151585 (+) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LL005_RS00670 (LL005_00675) 147410..148948 + 1539 WP_023345218.1 aldehyde dehydrogenase AldB -
LL005_RS00675 (LL005_00680) 148945..149910 - 966 WP_063435980.1 LysR family transcriptional regulator -
LL005_RS00680 (LL005_00685) 150028..150768 + 741 WP_021242443.1 MipA/OmpV family protein -
LL005_RS00685 (LL005_00690) 150978..151163 + 186 WP_071993467.1 type II toxin-antitoxin system HicA family toxin Toxin
LL005_RS00690 (LL005_00695) 151178..151585 + 408 WP_032675741.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LL005_RS00695 (LL005_00700) 151589..152665 - 1077 WP_233396192.1 type I restriction enzyme HsdR N-terminal domain-containing protein -
LL005_RS00700 (LL005_00705) 153011..153706 - 696 WP_032675742.1 L-ribulose-5-phosphate 4-epimerase -
LL005_RS00705 (LL005_00710) 153700..154560 - 861 WP_032675743.1 L-ribulose-5-phosphate 3-epimerase -
LL005_RS00710 (LL005_00715) 154563..155216 - 654 WP_032654530.1 3-keto-L-gulonate-6-phosphate decarboxylase UlaD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6882.06 Da        Isoelectric Point: 11.2341

>T222726 WP_071993467.1 NZ_CP086201:150978-151163 [Enterobacter roggenkampii]
VKSADVITVLISHGWKCVRTKGSHHQFRHPEQKGLVTVPHPKKDIKPGTLAQIWRQAGIKH

Download         Length: 186 bp

>T222726 NZ_CP118060:982149-982298 [Staphylococcus haemolyticus]
ATGACTAAAAATAAAGATTCAGAATTAAATTATCATGAGGAAGAAAATGCGATGGTTCAAGATTTAGATGACTTGAAAAC
ATTGGGCAAAGAAATGGAACAAATTTCTGAAGAAAACGACGAGGACAGGTTGAATCAATCGCATGAGTAA

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 15010.78 Da        Isoelectric Point: 4.3897

>AT222726 WP_032675741.1 NZ_CP086201:151178-151585 [Enterobacter roggenkampii]
MFYPAYIHSDSDGSASGFFPDVPGCFFAGDSLDDAFQDARDALTAHFEALFEMDNALPLPGNVEAHLESRPEDFTGGQWL
LVDINMKQFDGRAERINITMPRRLLVKIDSFVSEHPQFGNRSAFLAEAARRVLPG

Download         Length: 408 bp

>AT222726 NZ_CP118060:981527-982126 [Staphylococcus haemolyticus]
ATGGCAATGAACTTTAAAGTATTTAATGATGTAGAACATGTAGCTGAGTACACAGCAGATATCATTAGAAAGCAATTTAA
TAACAACCCTACAACTATTGCGGGAATTCATTTAACAAAGGATGCTGCACCTGTTATAGATGAGTTAAAGAAAGATGTAG
ATCATAATGCGGTTGATTTTAGTCAAGTAAATATCTTAGATTATGACGATAATCGCTCATACTATGAAGCATTAGGTGTA
CCTACTAGTCAAATTTATCCGATTAATCTTGACGATGATGCAGAATCTTTAATTGATGACAAAATTAAAACTAAAGAAAA
TAAAGGTAAATTAATTTTACAAGTTACTTCTATTGATGAATCAGGTAGTTTAAATGTAAATGTAAGACAAGGATTATTAA
AAGCGCGTGAAGTAGTATTAGTTGTGACTGGTGCTAATAAACGTGAAGTTGTTAAAAAACTTTATGAAGAAAATGGTAAA
TCTAGCTTTGAACCAGCTGATTTAAAAGCTCATAGAATGGTAACAGTTGTTTTAGATAGAGCAGCTGCAGAAGGTTTACC
TGAAGATGTTAAAGAATATTTCACTGCTAGATTTGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7H0N5B9

Antitoxin

Source ID Structure
AlphaFold DB A0A155E9Y3

References