Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-MazE
Location 45754..46415 Replicon chromosome
Accession NZ_CP086201
Organism Enterobacter roggenkampii strain F1057

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LL005_RS00230 Protein ID WP_205245870.1
Coordinates 46026..46415 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A156KC23
Locus tag LL005_RS00225 Protein ID WP_032675702.1
Coordinates 45754..46020 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LL005_RS00200 (LL005_00205) 41808..43136 - 1329 WP_023293713.1 PTS sugar transporter subunit IIC -
LL005_RS00205 (LL005_00210) 43148..43462 - 315 WP_095442769.1 PTS sugar transporter subunit IIB -
LL005_RS00210 (LL005_00215) 43756..44706 + 951 WP_023293714.1 LacI family DNA-binding transcriptional regulator -
LL005_RS00215 (LL005_00220) 44768..45064 - 297 WP_023326396.1 YicS family protein -
LL005_RS00220 (LL005_00225) 45205..45624 + 420 WP_032654363.1 GNAT family N-acetyltransferase -
LL005_RS00225 (LL005_00230) 45754..46020 + 267 WP_032675702.1 virulence protein Antitoxin
LL005_RS00230 (LL005_00235) 46026..46415 + 390 WP_205245870.1 type II toxin-antitoxin system VapC family toxin Toxin
LL005_RS00235 (LL005_00240) 46555..47355 + 801 WP_008500128.1 lipoprotein NlpA -
LL005_RS00240 (LL005_00245) 47478..48257 + 780 WP_032675705.1 MBL fold metallo-hydrolase -
LL005_RS00245 (LL005_00250) 48284..49237 + 954 WP_032675706.1 helix-turn-helix domain-containing protein -
LL005_RS00250 (LL005_00255) 49420..51117 + 1698 WP_233396675.1 ShlB/FhaC/HecB family hemolysin secretion/activation protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-118)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14374.48 Da        Isoelectric Point: 5.6732

>T222725 WP_205245870.1 NZ_CP086201:46026-46415 [Enterobacter roggenkampii]
MLDTNIVSHLFKRHPEVVSRMTCLAPGDVCISSITEAELLYGADKKKSSRLKETIREFLNTITICDWDSDAAATYGELRA
TLEKKGKVMGDLDQLIAAHAISRGTTIVTNDRAFRMVQELAVEDWTTTL

Download         Length: 390 bp

>T222725 NZ_CP118060:846538-846903 [Staphylococcus haemolyticus]
ATGATTAGAAGAGGCGATGTATATTTAGCTGATTTGTCACCAGTACAGGGCTCAGAACAAGGGGGAGTCAGACCTGTAGT
TATCATTCAAAACGATACTGGCAACAAATATAGTCCTACCGTAATCGTTGCTGCGATTACGGGAAGGATTAATAAAGCGA
AAATACCCACACATGTTGAAATCGAGAAAAAGAAATACAGACTTGATAAAGATTCAGTAATTCTACTCGAGCAAATTAGA
ACATTAGATAAAAAACGACTAAAAGAAAAATTAACATATCTATCTGATGAGAAAATGCAAGAAGTAGATGAAGCACTAGA
CATTAGTCTAGGACTGCATGATGAAGTTAAAACGCAAAACACATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10009.34 Da        Isoelectric Point: 4.6310

>AT222725 WP_032675702.1 NZ_CP086201:45754-46020 [Enterobacter roggenkampii]
MERTAKLFRKGQNQAVMLPAEFAFDTESVYIRRDEEGNVVLAAKPVLIKSWDNFLRMLAETDVPDTFLSKEERNQSVTTR
DPLDGACS

Download         Length: 267 bp

>AT222725 NZ_CP118060:846371-846541 [Staphylococcus haemolyticus]
ATGCTTACTTTCAATCAAAATAGAAGTCACAGTCTTGAACAATCTTTAAAAGAAGGCTATTCACAAATGGCTGAATTAAA
TCTCTCCCTAGCGACAGAAGCTTTTCCTCTAGAATGCGAAGCTTGTGATTGCAACGAAACGTACATTATTTCTAATTATA
AAAGTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A156KC23

References