Detailed information of TA system TA222723

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 3046282..3046838
• Replicon: chromosome
• Accession: NZ_CP086200
• Organism: Xanthomonas oryzae pv. oryzae strain GXO2006

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: LLC55_RS14250
• Protein ID: WP_229001948.1
• Coordinates: 3046587..3046838 (+)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A854CIX2
• Locus tag: LLC55_RS14245
• Protein ID: WP_011408759.1
• Coordinates: 3046282..3046560 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LLC55_RS14225 (LLC55_14230)	3041399..3041956	-	558	WP_011259349.1	DNA-3-methyladenine glycosylase	-
LLC55_RS14230 (LLC55_14235)	3042106..3043071	-	966	WP_109181928.1	IS1595-like element ISXo5 family transposase	-
LLC55_RS14235 (LLC55_14240)	3043652..3044836	+	1185	WP_011408397.1	IS256-like element IS1113 family transposase	-
LLC55_RS14240 (LLC55_14245)	3045742..3046086	+	345	WP_199285675.1	hypothetical protein	-
LLC55_RS14245 (LLC55_14255)	3046282..3046560	+	279	WP_011408759.1	CopG family ribbon-helix-helix protein	Antitoxin
LLC55_RS14250 (LLC55_14260)	3046587..3046838	+	252	WP_229001948.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LLC55_RS14255 (LLC55_14265)	3047099..3047296	+	198	WP_153296741.1	hypothetical protein	-
LLC55_RS14260 (LLC55_14270)	3047365..3047619	+	255	WP_223293127.1	hypothetical protein	-
LLC55_RS14265 (LLC55_14275)	3047836..3047955	+	120	Protein_2745	IS3 family transposase	-
LLC55_RS23485	3047924..3048052	+	129	WP_012444694.1	hypothetical protein	-
LLC55_RS14275 (LLC55_14285)	3048483..3048884	-	402	WP_011259345.1	H-NS family nucleoid-associated regulatory protein	-
LLC55_RS14280 (LLC55_14290)	3049106..3049282	+	177	Protein_2748	DUF3606 domain-containing protein	-
LLC55_RS14285 (LLC55_14300)	3049564..3049901	+	338	Protein_2749	ATP-dependent DNA ligase	-
LLC55_RS14290 (LLC55_14305)	3049977..3051068	-	1092	WP_041182166.1	ribonuclease D	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-81)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9603.92 Da
• Isoelectric Point: 9.9718

>T222723 WP_229001948.1 NZ_CP086200:3046587-3046838 [Xanthomonas oryzae pv. oryzae]
MLRLREFLRPKNPDAARRAGEAIRRGVQALGAHPRMGRLIEDLSEQYREWLIDFGDSGYVARYRFDGDTVTILAVRHQKE
AGY

Nucleotide

• Length: 252 bp

>T222723 NZ_CP118054:1388407-1389252 [Streptococcus anginosus]
ATGAATAAAGCAAAATTAACAGCACTCTGCCATAAAATATCGAAGAATACTGGATTAACTTTTAATTCCGTCATGACCTA
TTACTTTCTTGAAGCTATTCTGAAAAAATTAAGTCAGAGTTCTTATTCGAATCACTATATTTTTAAAGGTGGGTTCCTAC
TTTCAAACGTCATTGGGGTCGAATCTCGTAGTACGGCGGATATTGACTTCCTGTTTCATAAACAAACTTTATCAGAAGAA
AATATTCAACAACAGCTTGAAGAAATTTTAACTGAATCGAAAGATGGTATTCAATTTTCAATTCAATCCATAACAGCTAT
TAAGGAAAGCGATGATTATGGTGGTTACCGAGCAACCATTTTATGTCAACTCGAAAATATTAAACAAATTATCCATTTAG
ATATTGCGACTGGAGACATTGTCACACCTTACCCTGCTACCTATGACTACAAAGCCATTTTTGATGATGACAATTTTCCA
ATCATTGCTTATACGATTGAAACAATCTTAGCTGAAAAACTCCAAACCATTTATTCACGAAATTTCTTGAACAGTCGCAG
CAAAGATTTTTACGATGTCTATATCCTTTCAAAGCTAAAGAAAGATGACATTGATTTTTCACAATTAAAAATTGCTTGTG
AAAGAACCTTTTCCTATCGTGAAACTGAACTCGATTTCAATAAAATCATTGAACTACTGGAGAGATTCAAATCTGACTCT
ATTCAACAGCAACAATGGCAAAATTATTCAAAAAAATATAGCTATACAAAAGACATTCTATTCACAGATATACTTAATGA
GATTATCAGCCTCCTGATAGCTCTCAATTCTAATCATAACGCTTAA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10826.11 Da
• Isoelectric Point: 4.9736

>AT222723 WP_011408759.1 NZ_CP086200:3046282-3046560 [Xanthomonas oryzae pv. oryzae]
MVTATSIKLDDELKGRVQHLAESRRRTPHWIMREAIEQYVEREEKREALNRDTLKAWDEFQATGLHVTAEEVDKWLASWG
TDDELPPPECHK

Nucleotide

• Length: 279 bp

>AT222723 NZ_CP118054:1387820-1388410 [Streptococcus anginosus]
ATGTCTAAAAAAGAATTGTTACTTGAGTACTTAGACAGTCACAATGGCATGATTACTTATAGAGATTGTAAAAAATTAGG
TATTCCAACCATTTATCTAACGAGACTAGAAAACGAAGGGGTTATCTTTAGGGTCGATAAAGGAATCTATCTGTCCTCTA
GTGGAGATTATGATGAATACTATTTCTTTCAGTATCGTTACCCCAGAACTGTTTTTTCTCATATCTCTGCTCTTTATCTA
CAGGGACTTACAGATGAAATTCCTCAATATTTTGAAGTAACAGTCCCAAGGGACTACCGTTTTAGGAATACACCATTAAA
TTTAAATATCCACACTGTTTCTAAAGACATTGTCAACCTCGGGGTCACCAGTGTAAAAACTCCAATGGGAAACACCGTTA
ACGTTTATAATTTTGAACGTGTTCTGTGTGATTTTATCCTTAATCGAAATAACATTGATGCTGAGCTATTTGTTAAAACA
CTTCAAACTTATAGCAACTTCCCTAAAAAAAATCTCTCAAAGCTCTATGAATATGCTCAAAAACTGAATATCTTAGATGA
AGTTAAACGAACCTTGGAGGTACTACTATGA

Structures

Antitoxin

• AlphaFold DB: A0A854CIX2