Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2212355..2212869 Replicon chromosome
Accession NC_009641
Organism Staphylococcus aureus subsp. aureus str. Newman

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag NWMN_RS11510 Protein ID WP_000581792.1
Coordinates 2212355..2212564 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag NWMN_RS11515 Protein ID WP_000138932.1
Coordinates 2212576..2212869 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NWMN_RS11490 (NWMN_1986) 2207863..2209221 - 1359 WP_000611465.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
NWMN_RS11495 (NWMN_1987) 2209236..2210306 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
NWMN_RS11500 (NWMN_1988) 2210624..2211826 + 1203 WP_001109939.1 rod shape-determining protein RodA -
NWMN_RS11505 (NWMN_1989) 2212090..2212227 - 138 WP_000828354.1 hypothetical protein -
NWMN_RS11510 (NWMN_1990) 2212355..2212564 - 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
NWMN_RS11515 (NWMN_1991) 2212576..2212869 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
NWMN_RS11520 (NWMN_1992) 2213035..2214519 + 1485 WP_000571549.1 cardiolipin synthase -
NWMN_RS11525 (NWMN_1993) 2214547..2215194 + 648 WP_001187629.1 HD domain-containing protein -
NWMN_RS11540 (NWMN_1994) 2216007..2216879 - 873 WP_000725802.1 membrane protein insertase YidC -
NWMN_RS11545 (NWMN_1995) 2216965..2217606 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T22272 WP_000581792.1 NC_009641:c2212564-2212355 [Staphylococcus aureus subsp. aureus str. Newman]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T22272 NC_009641:c2212564-2212355 [Staphylococcus aureus subsp. aureus str. Newman]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT22272 WP_000138932.1 NC_009641:c2212869-2212576 [Staphylococcus aureus subsp. aureus str. Newman]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT22272 NC_009641:c2212869-2212576 [Staphylococcus aureus subsp. aureus str. Newman]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References