Detailed information of TA system TA222717

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1282679..1283166
• Replicon: chromosome
• Accession: NZ_CP086198
• Organism: Macrococcus canis strain KW0150

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LL975_RS06850
• Protein ID: WP_269886439.1
• Coordinates: 1282679..1282945 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: LL975_RS06855
• Protein ID: WP_236365521.1
• Coordinates: 1282942..1283166 (-)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LL975_RS06825 (LL975_06805)	1277756..1278796	-	1041	WP_254253295.1	M42 family metallopeptidase	-
LL975_RS06830 (LL975_06810)	1279055..1279243	-	189	WP_254253294.1	hypothetical protein	-
LL975_RS06835 (LL975_06815)	1279396..1280658	-	1263	WP_254254439.1	Y-family DNA polymerase	-
LL975_RS06840 (LL975_06820)	1281100..1282200	-	1101	WP_254254485.1	DUF1648 domain-containing protein	-
LL975_RS06845 (LL975_06825)	1282200..1282568	-	369	WP_269886438.1	GntR family transcriptional regulator	-
LL975_RS06850 (LL975_06830)	1282679..1282945	-	267	WP_269886439.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LL975_RS06855 (LL975_06835)	1282942..1283166	-	225	WP_236365521.1	DUF6290 family protein	Antitoxin
LL975_RS06860 (LL975_06840)	1283455..1283712	+	258	WP_086042496.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
LL975_RS06865 (LL975_06845)	1283705..1283977	+	273	WP_236365520.1	Txe/YoeB family addiction module toxin	-
LL975_RS06870 (LL975_06850)	1284000..1284455	-	456	WP_269887137.1	hypothetical protein	-
LL975_RS06875 (LL975_06855)	1284409..1284621	-	213	WP_254254481.1	type II toxin-antitoxin system YoeB family toxin	-
LL975_RS06880 (LL975_06860)	1284621..1284872	-	252	WP_254254480.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
LL975_RS06885 (LL975_06865)	1284947..1285333	-	387	WP_254254479.1	sporulation protein	-
LL975_RS06890 (LL975_06870)	1285495..1286499	+	1005	WP_254254478.1	cation diffusion facilitator family transporter	-
LL975_RS06895 (LL975_06875)	1286548..1286736	+	189	WP_086042483.1	2-hydroxymuconate tautomerase	-
LL975_RS06900 (LL975_06880)	1286774..1287715	-	942	WP_254254477.1	LCP family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-87)

Antitoxin

• Protein of unknown function DUF6290 (1-71)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10523.30 Da
• Isoelectric Point: 10.4082

>T222717 WP_269886439.1 NZ_CP086198:c1282945-1282679 [Macrococcus canis]
MKYSVEYDPKVIKQLRKLDAQSSRLLLQWINKNIVHCEDPRSSGKALTGNYSVFWRYRVGQFRIITKIEDDKLIILVISI
DHRKNIYR

Nucleotide

• Length: 267 bp

>T222717 NZ_CP118048:c2520242-2520138 [Enterococcus faecalis]
TTGTCAGCATATGAAACAATTCAGACGATCCTAGGGTTTGGTATGTTTACCATTGCTTTGATTGCGCTGATTGTGAAATT
GCTTAAAAATGACAATAAAAAATAA

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8745.91 Da
• Isoelectric Point: 4.4193

>AT222717 WP_236365521.1 NZ_CP086198:c1283166-1282942 [Macrococcus canis]
MATITIRVSEDEKNFLKYMSEFMNLSLTDLIKNYTIEDLEDLFDTHVADKAYIEWSKHKQTVSHNDVMQEFGLL

Nucleotide

• Length: 225 bp

>AT222717 NZ_CP118048:2520018-2520205 [Enterococcus faecalis]
TGTGCTATAATGAAAATGAAAAGAGAGATATGCTTCAACATACCTCTCTGATGTAGAGCCGTTTAAGACGGTGACCATGT
TAATTATTTAAAAATAACCGTGCTTGGTCAAAGTTGACGGTTATTTTTTATTGTCATTTTTAAGCAATTTCACAATCAGC
GCAATCAAAGCAATGGTAAACATACCAA