Detailed information of TA system TA222712

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 1486302..1486858
• Replicon: chromosome
• Accession: NZ_CP086197
• Organism: Xanthomonas oryzae strain JS97-2

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: LL929_RS06925
• Protein ID: WP_229001948.1
• Coordinates: 1486607..1486858 (+)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A854CIX2
• Locus tag: LL929_RS06920
• Protein ID: WP_011408759.1
• Coordinates: 1486302..1486580 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LL929_RS06900 (LL929_06900)	1481419..1481976	-	558	WP_011259349.1	DNA-3-methyladenine glycosylase	-
LL929_RS06905 (LL929_06905)	1482126..1483091	-	966	WP_109181928.1	IS1595-like element ISXo5 family transposase	-
LL929_RS06910 (LL929_06910)	1483672..1484856	+	1185	WP_011408760.1	IS256-like element IS1113 family transposase	-
LL929_RS06915 (LL929_06915)	1485762..1486106	+	345	WP_199285675.1	hypothetical protein	-
LL929_RS06920 (LL929_06920)	1486302..1486580	+	279	WP_011408759.1	CopG family ribbon-helix-helix protein	Antitoxin
LL929_RS06925 (LL929_06925)	1486607..1486858	+	252	WP_229001948.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LL929_RS06930 (LL929_06930)	1487119..1487316	+	198	WP_004541336.1	hypothetical protein	-
LL929_RS06935 (LL929_06935)	1487385..1487639	+	255	WP_223293127.1	hypothetical protein	-
LL929_RS06940 (LL929_06940)	1487856..1487975	+	120	Protein_1327	IS3 family transposase	-
LL929_RS06945	1487944..1488072	+	129	WP_012444694.1	hypothetical protein	-
LL929_RS06955 (LL929_06950)	1488503..1488904	-	402	WP_011259345.1	H-NS family nucleoid-associated regulatory protein	-
LL929_RS06960 (LL929_06955)	1489126..1489302	+	177	Protein_1330	DUF3606 domain-containing protein	-
LL929_RS06965 (LL929_06960)	1489584..1489921	+	338	Protein_1331	ATP-dependent DNA ligase	-
LL929_RS06970 (LL929_06965)	1489997..1491088	-	1092	WP_041182166.1	ribonuclease D	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-81)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9603.92 Da
• Isoelectric Point: 9.9718

>T222712 WP_229001948.1 NZ_CP086197:1486607-1486858 [Xanthomonas oryzae]
MLRLREFLRPKNPDAARRAGEAIRRGVQALGAHPRMGRLIEDLSEQYREWLIDFGDSGYVARYRFDGDTVTILAVRHQKE
AGY

Nucleotide

• Length: 252 bp

>T222712 NZ_CP118046:316591-317349 [Streptococcus anginosus]
ATGATAGCAGACTTTAGTACGGCTGACTTTGACCTAGCATTGAAACGAACCATTCGTTCCTTAACTCGTGGTAAAATCGC
TTCACCTGAGCCTAAAGCTATCTTATTGGGTGGACAAAGCGGAGCAGGCAAGACAACGATACATCGCATTAAACAAAAGG
AATTTCAAGGTAATATCATCATTATCGATGGTGATAGCTACCGTTCTTTACACCCCAATTACCTTGCTTTACAAGAAAAA
TATGGCAAAGATAGTGTTGATTATACAAAAGGTTTTGCAGGAAAAATGGTTGAACATCTTGTTGATGAGCTCAGCAAACA
AGGCTATCATCTGTTAATTGAAGGAACTCTGAGAACAACAGAAGTCCCACGAAAAACAGCTATACTATTGAAATCAAGGG
ACTACCAAGTGTCATTAGCGCTTATTGCCACAAAACCAGAACTGTCTTATCTAAGCACTCTCATTCGCTACGAGGAGCTC
TTTGCCATAGTCCCAAATCAAGCAAGGGCAACTCCTAAAGACCACCATGATGGAATTGTCAATCACTTGGTTGATAACTT
ACGAGAGCTAGAAAACGACCAACTCTTTGATTATATTCAAATTTACCAACGAGATAGAAGTTGTGTCTATGATTCGGAAA
CTGATGACGGTTCAGCTGCCGATGTTCTACAAAACTGTCTTTTGGGAAAATGGAGTAAGGTTGAGAAGGAAATGTTGAAG
GTGGACCAAGAACGGTTGAGAGAGATGCAAGAATTGTAG

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10826.11 Da
• Isoelectric Point: 4.9736

>AT222712 WP_011408759.1 NZ_CP086197:1486302-1486580 [Xanthomonas oryzae]
MVTATSIKLDDELKGRVQHLAESRRRTPHWIMREAIEQYVEREEKREALNRDTLKAWDEFQATGLHVTAEEVDKWLASWG
TDDELPPPECHK

Nucleotide

• Length: 279 bp

>AT222712 NZ_CP118046:316112-316588 [Streptococcus anginosus]
ATGATTGGAGAAAATATCAAATCGTTACGAAAAACGCATGATTTGACCCAACCTGAATTTGCCAAAATCATTGGAATTTC
TCGAAATAGTTTGAGCCGTTATGAAAATGGGACAAGTTCAGTATCAACAGAGCTCATAGACCGTATCTGTCAGAAATTTA
ATGTATCATATGTTGATATTGTAGGAGGAGAAAAAATGTTAACACCAGTGGAAGATTATCAATTAACCTTAAAAATTGAA
GTTATCAAAGAGCGTGGTGCTGCGATTTTAGCTCAGCTTTACCGTTACCAAGACAGTCAAGGCATTGCCTTTGACGACGA
AACAAATCCTTGGATTTTAATGAGTGATGACCTGTCTGTTCAAATTAATACAAAGATTTATCTTGTTGATACCTTTGATG
AAGTAGAACGTTATAATGGTTATTTAGACGGTATTGAACGTATGTTAGAAGTTGCCAGTCATCAGGTGGTGGCCTAG

Structures

Antitoxin

• AlphaFold DB: A0A854CIX2