Detailed information of TA system TA222706

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 708351..708907
• Replicon: chromosome
• Accession: NZ_CP086196
• Organism: Xanthomonas oryzae strain KS6-6

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: LL923_RS03310
• Protein ID: WP_229001948.1
• Coordinates: 708351..708602 (-)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A854CIX2
• Locus tag: LL923_RS03315
• Protein ID: WP_011408759.1
• Coordinates: 708629..708907 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LL923_RS03260 (LL923_03270)	704121..705212	+	1092	WP_011408756.1	ribonuclease D	-
LL923_RS03265 (LL923_03275)	705309..705625	-	317	Protein_621	ATP-dependent DNA ligase	-
LL923_RS03270 (LL923_03280)	705907..706083	-	177	Protein_622	DUF3606 domain-containing protein	-
LL923_RS03275 (LL923_03285)	706305..706706	+	402	WP_011259345.1	H-NS family nucleoid-associated regulatory protein	-
LL923_RS03285	707137..707265	-	129	WP_012444694.1	hypothetical protein	-
LL923_RS03290 (LL923_03295)	707234..707353	-	120	Protein_625	IS3 family transposase	-
LL923_RS03295 (LL923_03300)	707570..707824	-	255	WP_223293127.1	hypothetical protein	-
LL923_RS03300	707893..708027	-	135	WP_011408758.1	hypothetical protein	-
LL923_RS03305 (LL923_03305)	708020..708274	-	255	WP_198912806.1	hypothetical protein	-
LL923_RS03310 (LL923_03310)	708351..708602	-	252	WP_229001948.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LL923_RS03315 (LL923_03315)	708629..708907	-	279	WP_011408759.1	CopG family ribbon-helix-helix protein	Antitoxin
LL923_RS03320 (LL923_03320)	709103..709447	-	345	WP_199285675.1	hypothetical protein	-
LL923_RS03325 (LL923_03325)	710353..711537	-	1185	WP_011408397.1	IS256-like element IS1113 family transposase	-
LL923_RS03330 (LL923_03330)	712118..713083	+	966	WP_109181928.1	IS1595-like element ISXo5 family transposase	-
LL923_RS03335 (LL923_03335)	713233..713790	+	558	WP_011259349.1	DNA-3-methyladenine glycosylase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-81)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9603.92 Da
• Isoelectric Point: 9.9718

>T222706 WP_229001948.1 NZ_CP086196:c708602-708351 [Xanthomonas oryzae]
MLRLREFLRPKNPDAARRAGEAIRRGVQALGAHPRMGRLIEDLSEQYREWLIDFGDSGYVARYRFDGDTVTILAVRHQKE
AGY

Nucleotide

• Length: 252 bp

>T222706 NZ_CP118044:c827886-827698 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10826.11 Da
• Isoelectric Point: 4.9736

>AT222706 WP_011408759.1 NZ_CP086196:c708907-708629 [Xanthomonas oryzae]
MVTATSIKLDDELKGRVQHLAESRRRTPHWIMREAIEQYVEREEKREALNRDTLKAWDEFQATGLHVTAEEVDKWLASWG
TDDELPPPECHK

Nucleotide

• Length: 279 bp

>AT222706 NZ_CP118044:c828175-827915 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Structures

Antitoxin

• AlphaFold DB: A0A854CIX2