Detailed information of TA system TA222703

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 2958832..2959388
• Replicon: chromosome
• Accession: NZ_CP086195
• Organism: Xanthomonas oryzae strain JS158-2

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: LL925_RS13995
• Protein ID: WP_229001948.1
• Coordinates: 2958832..2959083 (-)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A854CIX2
• Locus tag: LL925_RS14000
• Protein ID: WP_011408759.1
• Coordinates: 2959110..2959388 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LL925_RS13950 (LL925_13950)	2954602..2955693	+	1092	WP_041182166.1	ribonuclease D	-
LL925_RS13955 (LL925_13955)	2955769..2956106	-	338	Protein_2662	ATP-dependent DNA ligase	-
LL925_RS13960 (LL925_13960)	2956388..2956564	-	177	Protein_2663	DUF3606 domain-containing protein	-
LL925_RS13965 (LL925_13965)	2956786..2957187	+	402	WP_011259345.1	H-NS family nucleoid-associated regulatory protein	-
LL925_RS13975	2957618..2957746	-	129	WP_012444694.1	hypothetical protein	-
LL925_RS13980 (LL925_13975)	2957715..2957834	-	120	Protein_2666	IS3 family transposase	-
LL925_RS13985 (LL925_13980)	2958051..2958305	-	255	WP_223293127.1	hypothetical protein	-
LL925_RS13990 (LL925_13985)	2958374..2958571	-	198	WP_004541336.1	hypothetical protein	-
LL925_RS13995 (LL925_13990)	2958832..2959083	-	252	WP_229001948.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LL925_RS14000 (LL925_13995)	2959110..2959388	-	279	WP_011408759.1	CopG family ribbon-helix-helix protein	Antitoxin
LL925_RS14005 (LL925_14000)	2959584..2959928	-	345	WP_199285675.1	hypothetical protein	-
LL925_RS14010 (LL925_14005)	2960834..2962017	-	1184	Protein_2672	IS256-like element IS1113 family transposase	-
LL925_RS14015 (LL925_14010)	2962598..2963563	+	966	WP_109181928.1	IS1595-like element ISXo5 family transposase	-
LL925_RS14020 (LL925_14015)	2963713..2964270	+	558	WP_011259349.1	DNA-3-methyladenine glycosylase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-81)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9603.92 Da
• Isoelectric Point: 9.9718

>T222703 WP_229001948.1 NZ_CP086195:c2959083-2958832 [Xanthomonas oryzae]
MLRLREFLRPKNPDAARRAGEAIRRGVQALGAHPRMGRLIEDLSEQYREWLIDFGDSGYVARYRFDGDTVTILAVRHQKE
AGY

Nucleotide

• Length: 252 bp

>T222703 NZ_CP118043:680315-680584 [Streptococcus agalactiae]
ATGGCGAATATTACTGACTTCACCGAAAAGCAATTTGAAGATCGTTTAGAAAAGAATGTTGAACGACTAACTAAAAATAG
ACTAGCGGTTGAATCGCCAACCGCTTTTTTACTTGGTGGGCAACCAGGATCAGGTAAAACTAGTTTGCGATCGGCAATTT
CCGAAGAGACACAAGGAAATGTTGTTATCATTGATAATGATACGTTCAAACAACAGCACCCTAGAAGCACGTTCGCCAAT
GTCAACAAGAGAAATAACTTTAACAGTTGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10826.11 Da
• Isoelectric Point: 4.9736

>AT222703 WP_011408759.1 NZ_CP086195:c2959388-2959110 [Xanthomonas oryzae]
MVTATSIKLDDELKGRVQHLAESRRRTPHWIMREAIEQYVEREEKREALNRDTLKAWDEFQATGLHVTAEEVDKWLASWG
TDDELPPPECHK

Nucleotide

• Length: 279 bp

>AT222703 NZ_CP118043:680041-680313 [Streptococcus agalactiae]
ATGGCAGTTACGTATGAAAAAACATTTGAAATAGAGATCATTAACGAATTATCGGCAAGCGTTTATAATCGAGTATTAAA
CTATGTTTTGAACCATGAACTAGATACTAAAAATACTCGTTTACTAGAAGTGAATCTTTTAAATCAATTAGAAGTGGCAC
AAGAAGTTGATTTATTTCAACAACCATTTGAAGAATTACAAGCTATTCATGAGTATTGGCGGTCAATGAATCAATATTCA
AAACAAATTTTGACAAAAGAGAAAGTGGCTTAA

Structures

Antitoxin

• AlphaFold DB: A0A854CIX2