Detailed information of TA system TA222698

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 2159347..2159903
• Replicon: chromosome
• Accession: NZ_CP086194
• Organism: Xanthomonas oryzae strain Z173

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: LL926_RS10035
• Protein ID: WP_229001948.1
• Coordinates: 2159652..2159903 (+)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A854CIX2
• Locus tag: LL926_RS10030
• Protein ID: WP_011408759.1
• Coordinates: 2159347..2159625 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LL926_RS10010 (LL926_10005)	2154464..2155021	-	558	WP_011259349.1	DNA-3-methyladenine glycosylase	-
LL926_RS10015 (LL926_10010)	2155171..2156136	-	966	WP_109181928.1	IS1595-like element ISXo5 family transposase	-
LL926_RS10020 (LL926_10015)	2156717..2157901	+	1185	WP_011408760.1	IS256-like element IS1113 family transposase	-
LL926_RS10025 (LL926_10020)	2158807..2159151	+	345	WP_199285675.1	hypothetical protein	-
LL926_RS10030 (LL926_10025)	2159347..2159625	+	279	WP_011408759.1	CopG family ribbon-helix-helix protein	Antitoxin
LL926_RS10035 (LL926_10030)	2159652..2159903	+	252	WP_229001948.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LL926_RS10040 (LL926_10035)	2159980..2160234	+	255	WP_198912806.1	hypothetical protein	-
LL926_RS10045	2160227..2160361	+	135	WP_011051575.1	hypothetical protein	-
LL926_RS10050 (LL926_10040)	2160430..2160684	+	255	WP_223293127.1	hypothetical protein	-
LL926_RS10055 (LL926_10045)	2160901..2161020	+	120	Protein_1929	IS3 family transposase	-
LL926_RS10060 (LL926_10050)	2161679..2161680	-	2	WP_109181906.1	IS5 family transposase	-
LL926_RS10070 (LL926_10060)	2162400..2162801	-	402	WP_011259345.1	H-NS family nucleoid-associated regulatory protein	-
LL926_RS10075 (LL926_10065)	2163023..2163199	+	177	Protein_1932	DUF3606 domain-containing protein	-
LL926_RS10080 (LL926_10070)	2163481..2163818	+	338	Protein_1933	ATP-dependent DNA ligase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	IScluster/Tn	-	-	2155171..2161950	6779

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-81)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9603.92 Da
• Isoelectric Point: 9.9718

>T222698 WP_229001948.1 NZ_CP086194:2159652-2159903 [Xanthomonas oryzae]
MLRLREFLRPKNPDAARRAGEAIRRGVQALGAHPRMGRLIEDLSEQYREWLIDFGDSGYVARYRFDGDTVTILAVRHQKE
AGY

Nucleotide

• Length: 252 bp

>T222698 NZ_CP118035:c2503200-2502853 [Lacticaseibacillus rhamnosus]
ATGACATATAAGGCTAAGCAAGGTGATGTGGTGTGGCTTGATTTTGATCCGTCCGAGGGTCATGAAATTAGAAAAAGATG
CCCAGCTGTTGTTTTAAGCAGTAACGCATACAATCGTGCAACCGGATTTGTGATTGTCGCACCAATTACCTCAACAATTC
GGACACTACCTGGTTATGTTGATATTGTATCCAATAAAATTCGTGGTCAGGTTGTCACTTCGCAGGTTTATTCTCTGGAT
GTCACTGAACAAGGCAACCGAAAAATCGATTTTATTGAAAGAATGAACATTGAAGATTTTTATACAGTCGCTCAATTCAC
CAAAATGAATTTTGATTTTAAATTTTAG

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10826.11 Da
• Isoelectric Point: 4.9736

>AT222698 WP_011408759.1 NZ_CP086194:2159347-2159625 [Xanthomonas oryzae]
MVTATSIKLDDELKGRVQHLAESRRRTPHWIMREAIEQYVEREEKREALNRDTLKAWDEFQATGLHVTAEEVDKWLASWG
TDDELPPPECHK

Nucleotide

• Length: 279 bp

>AT222698 NZ_CP118035:c2503418-2503200 [Lacticaseibacillus rhamnosus]
ATGATGGATGTGAAAGTTGTAAAACGTGGAAACTCGTTAGCTTTATCACTTCCGAGCAGTGCGGGTTTCAAACGAGGCGA
GGCGTTTTTGCTGATTTCAGATGAAAAAGGTGGTTATCTGTTGATCCCAAAGGTAAAAAATCCCTATACCAAAGCAAAAC
CATTATCATTCCATCAAGAAGAAGCTTGGCCGGATTTTGACTATGAGGATATTGAATAA

Structures

Antitoxin

• AlphaFold DB: A0A854CIX2