Detailed information of TA system TA222691

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 637607..638163
• Replicon: chromosome
• Accession: NZ_CP086193
• Organism: Xanthomonas oryzae strain GDV

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: LL918_RS02980
• Protein ID: WP_229001948.1
• Coordinates: 637607..637858 (-)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A854CIX2
• Locus tag: LL918_RS02985
• Protein ID: WP_011408759.1
• Coordinates: 637885..638163 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LL918_RS02935 (LL918_02940)	633377..634468	+	1092	WP_041182166.1	ribonuclease D	-
LL918_RS02940 (LL918_02945)	634544..634881	-	338	Protein_559	ATP-dependent DNA ligase	-
LL918_RS02945 (LL918_02950)	635163..635339	-	177	Protein_560	DUF3606 domain-containing protein	-
LL918_RS02950 (LL918_02955)	635561..635962	+	402	WP_011259345.1	H-NS family nucleoid-associated regulatory protein	-
LL918_RS02960	636393..636521	-	129	WP_012444694.1	hypothetical protein	-
LL918_RS02965 (LL918_02965)	636490..636609	-	120	Protein_563	IS3 family transposase	-
LL918_RS02970 (LL918_02970)	636826..637080	-	255	WP_223293127.1	hypothetical protein	-
LL918_RS02975 (LL918_02975)	637149..637346	-	198	WP_004541336.1	hypothetical protein	-
LL918_RS02980 (LL918_02980)	637607..637858	-	252	WP_229001948.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LL918_RS02985 (LL918_02985)	637885..638163	-	279	WP_011408759.1	CopG family ribbon-helix-helix protein	Antitoxin
LL918_RS02990 (LL918_02990)	638359..638703	-	345	WP_199285675.1	hypothetical protein	-
LL918_RS02995 (LL918_02995)	639609..640793	-	1185	WP_011408397.1	IS256-like element IS1113 family transposase	-
LL918_RS03000 (LL918_03000)	641374..642339	+	966	WP_109181928.1	IS1595-like element ISXo5 family transposase	-
LL918_RS03005 (LL918_03005)	642489..643046	+	558	WP_011259349.1	DNA-3-methyladenine glycosylase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-81)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9603.92 Da
• Isoelectric Point: 9.9718

>T222691 WP_229001948.1 NZ_CP086193:c637858-637607 [Xanthomonas oryzae]
MLRLREFLRPKNPDAARRAGEAIRRGVQALGAHPRMGRLIEDLSEQYREWLIDFGDSGYVARYRFDGDTVTILAVRHQKE
AGY

Nucleotide

• Length: 252 bp

>T222691 NZ_CP118015:c33579-33304 [Escherichia coli]
ATGGAACTGAAGTGGACCAGTAAGGCGCTTTCTGATTTGGCGCGGTTATATGATTTTCTGGTGCTGACCAGTAAACCTGC
GGCCGCCAGAACGGTGCAGTCCCTGACACATGCTCCGGTCATTCTGTTAACTCATCCACGTATGGGAGAACAGTTGTTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAACTTAATGGCCAGACTATTTAT
GTATTGCGCCTGTGGCACACACGAGAAAACAGGTAG

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10826.11 Da
• Isoelectric Point: 4.9736

>AT222691 WP_011408759.1 NZ_CP086193:c638163-637885 [Xanthomonas oryzae]
MVTATSIKLDDELKGRVQHLAESRRRTPHWIMREAIEQYVEREEKREALNRDTLKAWDEFQATGLHVTAEEVDKWLASWG
TDDELPPPECHK

Nucleotide

• Length: 279 bp

>AT222691 NZ_CP118015:c33863-33579 [Escherichia coli]
ATGCAAATGAAAAACAATACCGCACAAGCAACAAAAGTAATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGCTCCCGGGGCTGGATTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAGGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATCGACCATCAGGCTGTACAGGCCTGG
GCGGACAGCCTCAGTACTGACAATCCGTTACCGGTGCCACGCTGA

Structures

Antitoxin

• AlphaFold DB: A0A854CIX2