Detailed information of TA system TA222690

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 4523639..4524195
• Replicon: chromosome
• Accession: NZ_CP086191
• Organism: Xanthomonas oryzae strain JS49-6

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: LL928_RS21340
• Protein ID: WP_229001948.1
• Coordinates: 4523639..4523890 (-)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A854CIX2
• Locus tag: LL928_RS21345
• Protein ID: WP_011408759.1
• Coordinates: 4523917..4524195 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LL928_RS21300 (LL928_21270)	4519409..4520500	+	1092	WP_041182166.1	ribonuclease D	-
LL928_RS21305 (LL928_21275)	4520576..4520913	-	338	Protein_4067	ATP-dependent DNA ligase	-
LL928_RS21310 (LL928_21280)	4521195..4521371	-	177	Protein_4068	DUF3606 domain-containing protein	-
LL928_RS21315 (LL928_21285)	4521593..4521994	+	402	WP_011259345.1	H-NS family nucleoid-associated regulatory protein	-
LL928_RS21325 (LL928_21295)	4522522..4522641	-	120	Protein_4070	IS3 family transposase	-
LL928_RS21330 (LL928_21300)	4522858..4523112	-	255	WP_223293127.1	hypothetical protein	-
LL928_RS21335 (LL928_21305)	4523181..4523378	-	198	WP_004541336.1	hypothetical protein	-
LL928_RS21340 (LL928_21310)	4523639..4523890	-	252	WP_229001948.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LL928_RS21345 (LL928_21315)	4523917..4524195	-	279	WP_011408759.1	CopG family ribbon-helix-helix protein	Antitoxin
LL928_RS21350 (LL928_21320)	4524391..4524735	-	345	WP_199285675.1	hypothetical protein	-
LL928_RS21355 (LL928_21325)	4525641..4526825	-	1185	WP_011408397.1	IS256-like element IS1113 family transposase	-
LL928_RS21360 (LL928_21330)	4527406..4528371	+	966	WP_109181928.1	IS1595-like element ISXo5 family transposase	-
LL928_RS21365 (LL928_21335)	4528521..4529078	+	558	WP_011259349.1	DNA-3-methyladenine glycosylase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-81)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9603.92 Da
• Isoelectric Point: 9.9718

>T222690 WP_229001948.1 NZ_CP086191:c4523890-4523639 [Xanthomonas oryzae]
MLRLREFLRPKNPDAARRAGEAIRRGVQALGAHPRMGRLIEDLSEQYREWLIDFGDSGYVARYRFDGDTVTILAVRHQKE
AGY

Nucleotide

• Length: 252 bp

>T222690 NZ_CP118014:c4998254-4997904 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10826.11 Da
• Isoelectric Point: 4.9736

>AT222690 WP_011408759.1 NZ_CP086191:c4524195-4523917 [Xanthomonas oryzae]
MVTATSIKLDDELKGRVQHLAESRRRTPHWIMREAIEQYVEREEKREALNRDTLKAWDEFQATGLHVTAEEVDKWLASWG
TDDELPPPECHK

Nucleotide

• Length: 279 bp

>AT222690 NZ_CP118014:c4998499-4998248 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGCGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A854CIX2