Detailed information of TA system TA222684

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): rlegTA/AbiEii-AbiEi
• Location: 4682668..4684187
• Replicon: chromosome
• Accession: NZ_CP086188
• Organism: Xanthomonas oryzae strain PXO79

Toxin (Protein)

• Gene name: rlegT
• Uniprot ID: A0A0K0GMB6
• Locus tag: LL930_RS21905
• Protein ID: WP_011259680.1
• Coordinates: 4682668..4683591 (-)
• Length: 308 a.a.

Antitoxin (Protein)

• Gene name: rlegA
• Uniprot ID: A0A854CLN1
• Locus tag: LL930_RS21910
• Protein ID: WP_011409027.1
• Coordinates: 4683588..4684187 (-)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LL930_RS21875 (LL930_21845)	4678267..4678419	+	153	Protein_4193	SAM-dependent methyltransferase	-
LL930_RS21880 (LL930_21850)	4678531..4679907	+	1377	Protein_4194	IS5 family transposase	-
LL930_RS21885 (LL930_21855)	4679927..4680459	+	533	Protein_4195	methyltransferase domain-containing protein	-
LL930_RS21890 (LL930_21860)	4680476..4680985	-	510	WP_011259678.1	hypothetical protein	-
LL930_RS21895 (LL930_21865)	4681410..4681652	-	243	WP_011259679.1	hypothetical protein	-
LL930_RS21900 (LL930_21870)	4682118..4682588	+	471	WP_228329666.1	helix-turn-helix domain-containing protein	-
LL930_RS21905 (LL930_21875)	4682668..4683591	-	924	WP_011259680.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
LL930_RS21910 (LL930_21880)	4683588..4684187	-	600	WP_011409027.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
LL930_RS21915 (LL930_21885)	4684552..4684842	+	291	WP_233282844.1	FaeA/PapI family transcriptional regulator	-
LL930_RS21920 (LL930_21890)	4684874..4685362	+	489	WP_044756654.1	BrxE family protein	-
LL930_RS21925 (LL930_21895)	4685876..4685877	-	2	WP_094187731.1	IS5 family transposase	-
LL930_RS21930 (LL930_21900)	4686283..4687316	-	1034	Protein_4204	IS630 family transposase	-
LL930_RS21935 (LL930_21905)	4687875..4688105	+	231	WP_012445460.1	hypothetical protein	-
LL930_RS21940 (LL930_21910)	4688086..4688460	+	375	WP_229002607.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (41-269)

Antitoxin

• Transcriptional regulator, AbiEi antitoxin (7-52)

Sequences

Toxin

Protein

• Length: 308 a.a.
• Molecular weight: 34114.16 Da
• Isoelectric Point: 5.4588

>T222684 WP_011259680.1 NZ_CP086188:c4683591-4682668 [Xanthomonas oryzae]
MNEPDKSRRTVAASVRARLLNKARAERLDFNLLLTRYALERVLYRLSVSEQQGQFLLKGALLFDIWFDIPHRPTHDADLL
GFGSTEIPHLEDLFRRISQIASDDGIVFQADSVKAAEIRKEANYAGVRVTMIGLLDGARCTVQIDIGFGDAVTPGPDNVQ
YPVILDGMPQPQLRVYPRYTVVAEKLEAMVKLGILNSRMKDYFDLWVLAGHSDFDGAVLATAIRATFECRGTAIPPGAPL
GLTDEFGLDEQKTKQWQAFLRKNTLEPMPLTTVIEALREFVLPVLAALAAGEGFDRQWRAGAGWDAA

Nucleotide

• Length: 924 bp

>T222684 NZ_CP118014:3395607-3395714 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22037.74 Da
• Isoelectric Point: 10.1240

>AT222684 WP_011409027.1 NZ_CP086188:c4684187-4683588 [Xanthomonas oryzae]
MDTTVDKLLELVRTRGLLRPHDLAPLGIPRVALTRAVRRGQLERVGRGLYGLVARPVSAHGTLAEVARRVPKGVVCLLSA
LRVHDLTTQAPFEVWLAIDNKAAAPKLDYPPLRLVRFSGPALSEGVEEHVVDGVPVHVTSVAKTVADCFKYRNKIGIDVA
LEALREAWVARRMTSDEIWHYAKIDRVANVMRPYLESLA

Nucleotide

• Length: 600 bp

>AT222684 NZ_CP118014:c3395557-3395494 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTAAACCTCTCAACGTGCGGGGGTTTTCT

Structures

Toxin

• AlphaFold DB: A0A0K0GMB6

Antitoxin

• AlphaFold DB: A0A854CLN1