Detailed information of TA system TA222677

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 180033..180589
• Replicon: chromosome
• Accession: NZ_CP086185
• Organism: Xanthomonas oryzae strain PXO112

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: LL920_RS00885
• Protein ID: WP_229001948.1
• Coordinates: 180033..180284 (-)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A854CIX2
• Locus tag: LL920_RS00890
• Protein ID: WP_011408759.1
• Coordinates: 180311..180589 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LL920_RS00835 (LL920_00835)	175803..176894	+	1092	WP_011408756.1	ribonuclease D	-
LL920_RS00840 (LL920_00840)	176991..177307	-	317	Protein_162	ATP-dependent DNA ligase	-
LL920_RS00845 (LL920_00845)	177589..177765	-	177	Protein_163	DUF3606 domain-containing protein	-
LL920_RS00850 (LL920_00850)	177987..178388	+	402	WP_011259345.1	H-NS family nucleoid-associated regulatory protein	-
LL920_RS00860	178819..178947	-	129	WP_012444694.1	hypothetical protein	-
LL920_RS00865 (LL920_00860)	178916..179035	-	120	Protein_166	IS3 family transposase	-
LL920_RS00870 (LL920_00865)	179252..179506	-	255	WP_223293127.1	hypothetical protein	-
LL920_RS00875	179575..179709	-	135	WP_011408758.1	hypothetical protein	-
LL920_RS00880 (LL920_00870)	179702..179956	-	255	WP_198912806.1	hypothetical protein	-
LL920_RS00885 (LL920_00875)	180033..180284	-	252	WP_229001948.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LL920_RS00890 (LL920_00880)	180311..180589	-	279	WP_011408759.1	CopG family ribbon-helix-helix protein	Antitoxin
LL920_RS00895 (LL920_00885)	180785..181129	-	345	WP_198912817.1	hypothetical protein	-
LL920_RS00900 (LL920_00890)	181523..182479	-	957	WP_041182545.1	IS30-like element IS1112b family transposase	-
LL920_RS00905 (LL920_00895)	182839..184157	-	1319	Protein_174	IS701-like element ISXo15 family transposase	-
LL920_RS00910 (LL920_00900)	184294..185262	+	969	WP_012446083.1	IS5-like element ISXo1 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-81)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9603.92 Da
• Isoelectric Point: 9.9718

>T222677 WP_229001948.1 NZ_CP086185:c180284-180033 [Xanthomonas oryzae]
MLRLREFLRPKNPDAARRAGEAIRRGVQALGAHPRMGRLIEDLSEQYREWLIDFGDSGYVARYRFDGDTVTILAVRHQKE
AGY

Nucleotide

• Length: 252 bp

>T222677 NZ_CP118014:2512406-2512660 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10826.11 Da
• Isoelectric Point: 4.9736

>AT222677 WP_011408759.1 NZ_CP086185:c180589-180311 [Xanthomonas oryzae]
MVTATSIKLDDELKGRVQHLAESRRRTPHWIMREAIEQYVEREEKREALNRDTLKAWDEFQATGLHVTAEEVDKWLASWG
TDDELPPPECHK

Nucleotide

• Length: 279 bp

>AT222677 NZ_CP118014:2512158-2512409 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Structures

Antitoxin

• AlphaFold DB: A0A854CIX2