Detailed information of TA system TA222674

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 1568820..1569376
• Replicon: chromosome
• Accession: NZ_CP086184
• Organism: Xanthomonas oryzae strain PXO280

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: LL919_RS07315
• Protein ID: WP_229001948.1
• Coordinates: 1569125..1569376 (+)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A854CIX2
• Locus tag: LL919_RS07310
• Protein ID: WP_011408759.1
• Coordinates: 1568820..1569098 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LL919_RS07290 (LL919_07285)	1563973..1565157	+	1185	WP_011408397.1	IS256-like element IS1113 family transposase	-
LL919_RS07295 (LL919_07290)	1565561..1566528	+	968	WP_012445118.1	IS5-like element ISXo1 family transposase	-
LL919_RS07300 (LL919_07295)	1566930..1567886	+	957	WP_041182719.1	IS30-like element IS1112b family transposase	-
LL919_RS07305 (LL919_07300)	1568280..1568624	+	345	WP_198912817.1	hypothetical protein	-
LL919_RS07310 (LL919_07305)	1568820..1569098	+	279	WP_011408759.1	CopG family ribbon-helix-helix protein	Antitoxin
LL919_RS07315 (LL919_07310)	1569125..1569376	+	252	WP_229001948.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LL919_RS07320 (LL919_07315)	1569453..1569707	+	255	WP_198912806.1	hypothetical protein	-
LL919_RS07325	1569700..1569834	+	135	WP_011408758.1	hypothetical protein	-
LL919_RS07330 (LL919_07320)	1569903..1570157	+	255	WP_223293127.1	hypothetical protein	-
LL919_RS07335 (LL919_07325)	1570374..1570493	+	120	Protein_1406	IS3 family transposase	-
LL919_RS07340	1570462..1570590	+	129	WP_012444694.1	hypothetical protein	-
LL919_RS07350 (LL919_07335)	1571021..1571422	-	402	WP_011259345.1	H-NS family nucleoid-associated regulatory protein	-
LL919_RS07355 (LL919_07340)	1571644..1571820	+	177	Protein_1409	DUF3606 domain-containing protein	-
LL919_RS07360 (LL919_07345)	1572102..1572418	+	317	Protein_1410	ATP-dependent DNA ligase	-
LL919_RS07365 (LL919_07350)	1572515..1573606	-	1092	WP_011408756.1	ribonuclease D	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-81)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9603.92 Da
• Isoelectric Point: 9.9718

>T222674 WP_229001948.1 NZ_CP086184:1569125-1569376 [Xanthomonas oryzae]
MLRLREFLRPKNPDAARRAGEAIRRGVQALGAHPRMGRLIEDLSEQYREWLIDFGDSGYVARYRFDGDTVTILAVRHQKE
AGY

Nucleotide

• Length: 252 bp

>T222674 NZ_CP118014:1638654-1638989 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10826.11 Da
• Isoelectric Point: 4.9736

>AT222674 WP_011408759.1 NZ_CP086184:1568820-1569098 [Xanthomonas oryzae]
MVTATSIKLDDELKGRVQHLAESRRRTPHWIMREAIEQYVEREEKREALNRDTLKAWDEFQATGLHVTAEEVDKWLASWG
TDDELPPPECHK

Nucleotide

• Length: 279 bp

>AT222674 NZ_CP118014:1638406-1638654 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A854CIX2