Detailed information of TA system TA222670

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 2334225..2334781
• Replicon: chromosome
• Accession: NZ_CP086183
• Organism: Xanthomonas oryzae strain PXO341

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: LL922_RS10875
• Protein ID: WP_229001948.1
• Coordinates: 2334530..2334781 (+)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A854CIX2
• Locus tag: LL922_RS10870
• Protein ID: WP_011408759.1
• Coordinates: 2334225..2334503 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LL922_RS10850 (LL922_10845)	2329342..2329899	-	558	WP_011259349.1	DNA-3-methyladenine glycosylase	-
LL922_RS10855 (LL922_10850)	2330049..2331014	-	966	WP_109181928.1	IS1595-like element ISXo5 family transposase	-
LL922_RS10860 (LL922_10855)	2331595..2332779	+	1185	WP_011408522.1	IS256-like element IS1113 family transposase	-
LL922_RS10865 (LL922_10860)	2333685..2334029	+	345	WP_199285675.1	hypothetical protein	-
LL922_RS10870 (LL922_10865)	2334225..2334503	+	279	WP_011408759.1	CopG family ribbon-helix-helix protein	Antitoxin
LL922_RS10875 (LL922_10870)	2334530..2334781	+	252	WP_229001948.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LL922_RS10880 (LL922_10875)	2334858..2335112	+	255	WP_198912806.1	hypothetical protein	-
LL922_RS10885	2335105..2335239	+	135	WP_011051575.1	hypothetical protein	-
LL922_RS10890 (LL922_10880)	2335308..2335562	+	255	WP_223293127.1	hypothetical protein	-
LL922_RS10895 (LL922_10885)	2335779..2335898	+	120	Protein_2093	IS3 family transposase	-
LL922_RS10900	2335867..2335995	+	129	WP_012444694.1	hypothetical protein	-
LL922_RS10910 (LL922_10895)	2336426..2336827	-	402	WP_011259345.1	H-NS family nucleoid-associated regulatory protein	-
LL922_RS10915 (LL922_10900)	2337049..2337225	+	177	Protein_2096	DUF3606 domain-containing protein	-
LL922_RS10920 (LL922_10905)	2337507..2337844	+	338	Protein_2097	ATP-dependent DNA ligase	-
LL922_RS10925 (LL922_10910)	2337920..2339011	-	1092	WP_041182166.1	ribonuclease D	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-81)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9603.92 Da
• Isoelectric Point: 9.9718

>T222670 WP_229001948.1 NZ_CP086183:2334530-2334781 [Xanthomonas oryzae]
MLRLREFLRPKNPDAARRAGEAIRRGVQALGAHPRMGRLIEDLSEQYREWLIDFGDSGYVARYRFDGDTVTILAVRHQKE
AGY

Nucleotide

• Length: 252 bp

>T222670 NZ_CP118014:876262-876492 [Escherichia coli]
CTGGATCAGCTATTTAAATCACCTTTACCTCAAGGAATCAAATGGACTGATATAGAATCTCTGGTTAAAGCGTTAGGCGG
AGAAATTAAGGAAGGTAGGGGGTCGCGCTGTAAGTTCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGT
CGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTGCGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10826.11 Da
• Isoelectric Point: 4.9736

>AT222670 WP_011408759.1 NZ_CP086183:2334225-2334503 [Xanthomonas oryzae]
MVTATSIKLDDELKGRVQHLAESRRRTPHWIMREAIEQYVEREEKREALNRDTLKAWDEFQATGLHVTAEEVDKWLASWG
TDDELPPPECHK

Nucleotide

• Length: 279 bp

>AT222670 NZ_CP118014:876489-876848 [Escherichia coli]
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCTGCTGTTATCACTTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AACTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA

Structures

Antitoxin

• AlphaFold DB: A0A854CIX2