Detailed information of TA system TA222664

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 1760308..1760864
• Replicon: chromosome
• Accession: NZ_CP086182
• Organism: Xanthomonas oryzae strain PXO347

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: LL921_RS08205
• Protein ID: WP_229001948.1
• Coordinates: 1760613..1760864 (+)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A854CIX2
• Locus tag: LL921_RS08200
• Protein ID: WP_011408759.1
• Coordinates: 1760308..1760586 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LL921_RS08180 (LL921_08180)	1755425..1755982	-	558	WP_011259349.1	DNA-3-methyladenine glycosylase	-
LL921_RS08185 (LL921_08185)	1756132..1757097	-	966	WP_109181928.1	IS1595-like element ISXo5 family transposase	-
LL921_RS08190 (LL921_08190)	1757678..1758862	+	1185	WP_011408397.1	IS256-like element IS1113 family transposase	-
LL921_RS08195 (LL921_08195)	1759768..1760112	+	345	WP_199285675.1	hypothetical protein	-
LL921_RS08200 (LL921_08200)	1760308..1760586	+	279	WP_011408759.1	CopG family ribbon-helix-helix protein	Antitoxin
LL921_RS08205 (LL921_08205)	1760613..1760864	+	252	WP_229001948.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LL921_RS08210 (LL921_08210)	1761125..1761322	+	198	WP_004541336.1	hypothetical protein	-
LL921_RS08215 (LL921_08215)	1761391..1761645	+	255	WP_223293127.1	hypothetical protein	-
LL921_RS08220 (LL921_08220)	1761862..1761981	+	120	Protein_1571	IS3 family transposase	-
LL921_RS08225	1761950..1762078	+	129	WP_012444694.1	hypothetical protein	-
LL921_RS08235 (LL921_08230)	1762509..1762910	-	402	WP_011259345.1	H-NS family nucleoid-associated regulatory protein	-
LL921_RS08240 (LL921_08235)	1763132..1763308	+	177	Protein_1574	DUF3606 domain-containing protein	-
LL921_RS08245 (LL921_08240)	1763590..1763927	+	338	Protein_1575	ATP-dependent DNA ligase	-
LL921_RS08250 (LL921_08245)	1764003..1765094	-	1092	WP_041182166.1	ribonuclease D	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-81)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9603.92 Da
• Isoelectric Point: 9.9718

>T222664 WP_229001948.1 NZ_CP086182:1760613-1760864 [Xanthomonas oryzae]
MLRLREFLRPKNPDAARRAGEAIRRGVQALGAHPRMGRLIEDLSEQYREWLIDFGDSGYVARYRFDGDTVTILAVRHQKE
AGY

Nucleotide

• Length: 252 bp

>T222664 NZ_CP117994:1893894-1894193 [Vibrio alginolyticus]
ATGAGACCATTTCAGTTAACTAACAAGGCGAAATCTGATTTAAGAGATATAGCCTTGTTTACCTCTCGACGCTGGGGTCG
TGAACAGCGAAATATTTATCTAAAACAGTTTGATGACTCATTTTGGCTGTTAGCCGAAAACCCTGACATTGGTAAAACCT
GTGACGAAATTCGCGATGGATACAGAAAATTCCCCCAAGGAAGCCACGTAATATTTTATCGTCAGATCGGCAGTCAAAAT
ATTGAGATTATCCGTATACTCCACAAAAGCATGGATGTGAATCCAATTTTTGGCGCATAA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10826.11 Da
• Isoelectric Point: 4.9736

>AT222664 WP_011408759.1 NZ_CP086182:1760308-1760586 [Xanthomonas oryzae]
MVTATSIKLDDELKGRVQHLAESRRRTPHWIMREAIEQYVEREEKREALNRDTLKAWDEFQATGLHVTAEEVDKWLASWG
TDDELPPPECHK

Nucleotide

• Length: 279 bp

>AT222664 NZ_CP117994:1893655-1893897 [Vibrio alginolyticus]
ATGGCTAAGAACACTAGTATTACTTTGGGTGACCATTTTGACGGTTTTATTGCTAATCAAATCCAAAGCGGTCGCTATGC
CTCTGCAAGTGAAGTCATTCGTTCCGCTTTACGTTTACTTGAAACCCAAGAAACTAAAATGAACACTTTACGCCAATTAC
TTGTTGAAGGTGAAGAAAGTGGAGTTGCGGATTATGACCTTGATTCGTTTATCAATGAGTTAGATAGCGAAGAGAAAAAA
TGA

Structures

Antitoxin

• AlphaFold DB: A0A854CIX2