Detailed information of TA system TA222660

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 2815863..2816419
• Replicon: chromosome
• Accession: NZ_CP086181
• Organism: Xanthomonas oryzae strain PXO349

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: LL917_RS13340
• Protein ID: WP_229001948.1
• Coordinates: 2815863..2816114 (-)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A854CIX2
• Locus tag: LL917_RS13345
• Protein ID: WP_011408759.1
• Coordinates: 2816141..2816419 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LL917_RS13295 (LL917_13295)	2811633..2812724	+	1092	WP_041182166.1	ribonuclease D	-
LL917_RS13300 (LL917_13300)	2812800..2813137	-	338	Protein_2535	ATP-dependent DNA ligase	-
LL917_RS13305 (LL917_13305)	2813419..2813595	-	177	Protein_2536	DUF3606 domain-containing protein	-
LL917_RS13310 (LL917_13310)	2813817..2814218	+	402	WP_011259345.1	H-NS family nucleoid-associated regulatory protein	-
LL917_RS13320	2814649..2814777	-	129	WP_012444694.1	hypothetical protein	-
LL917_RS13325 (LL917_13320)	2814746..2814865	-	120	Protein_2539	IS3 family transposase	-
LL917_RS13330 (LL917_13325)	2815082..2815336	-	255	WP_223293127.1	hypothetical protein	-
LL917_RS13335 (LL917_13330)	2815405..2815602	-	198	WP_004541336.1	hypothetical protein	-
LL917_RS13340 (LL917_13335)	2815863..2816114	-	252	WP_229001948.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LL917_RS13345 (LL917_13340)	2816141..2816419	-	279	WP_011408759.1	CopG family ribbon-helix-helix protein	Antitoxin
LL917_RS13350 (LL917_13345)	2816615..2816959	-	345	WP_199285675.1	hypothetical protein	-
LL917_RS13355 (LL917_13350)	2817865..2819049	-	1185	WP_011408397.1	IS256-like element IS1113 family transposase	-
LL917_RS13360 (LL917_13355)	2819630..2820595	+	966	WP_109181928.1	IS1595-like element ISXo5 family transposase	-
LL917_RS13365 (LL917_13360)	2820745..2821302	+	558	WP_011259349.1	DNA-3-methyladenine glycosylase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-81)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9603.92 Da
• Isoelectric Point: 9.9718

>T222660 WP_229001948.1 NZ_CP086181:c2816114-2815863 [Xanthomonas oryzae]
MLRLREFLRPKNPDAARRAGEAIRRGVQALGAHPRMGRLIEDLSEQYREWLIDFGDSGYVARYRFDGDTVTILAVRHQKE
AGY

Nucleotide

• Length: 252 bp

>T222660 NZ_CP117993:c3851576-3851289 [Enterobacter hormaechei]
ATGCCTATAGAGTATGAATGGGATAGCAATAAGGCGAAAAGCAATCTGCAAAAACACGCCATTCGTTTTGAAGATGCAGT
TCTGGTTTTTGACGATCCCTGCCATTTGTCTGTTCAGGATCGTTATGAAAACGGGGAGTTTCGCTGGCAAACCATTGGTC
TTGTACAGGGCGTTATTGTCATTCTGGTCGCGCACACGGTACGTTTTGAAAGCGGGGATGAAATCATACGTATCATCAGT
GCGCGTAAAGCGGATCGTAAAGAGAGGAGGCGTTATGAGCATCGTTAA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10826.11 Da
• Isoelectric Point: 4.9736

>AT222660 WP_011408759.1 NZ_CP086181:c2816419-2816141 [Xanthomonas oryzae]
MVTATSIKLDDELKGRVQHLAESRRRTPHWIMREAIEQYVEREEKREALNRDTLKAWDEFQATGLHVTAEEVDKWLASWG
TDDELPPPECHK

Nucleotide

• Length: 279 bp

>AT222660 NZ_CP117993:c3851302-3851000 [Enterobacter hormaechei]
ATGAGCATCGTTAAACATAAACGCGGTAGTGCACCGGAAGTGAGTGCGCGCCGGGAGGCTGAACTCAAAGCGCTGGCGGA
TAAACCCGACAGGGAAATTGATTACAGCGATATACCGGCCACGGAGGATGATCGCTGGGCCGGTGCCGTGCGGGGAAAAT
TCTATCGACCGCTCAAAACTCAGGCATCAGTACGCATTGACGCCGACGTGATGGAGTGGCTTAAACGGCCAGGGAAAGGT
TACCAGACGCGGCTTAATGCCATTTTGCGCGAGGCGATGCTGCGCGATCAGAACAAAAAATAA

Structures

Antitoxin

• AlphaFold DB: A0A854CIX2