Detailed information of TA system TA222652

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 4033566..4034194
• Replicon: chromosome
• Accession: NZ_CP086179
• Organism: Streptomyces fungicidicus strain F1

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: LLI13_RS18275
• Protein ID: WP_121546814.1
• Coordinates: 4033784..4034194 (+)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: D9XL36
• Locus tag: LLI13_RS18270
• Protein ID: WP_004928730.1
• Coordinates: 4033566..4033787 (+)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LLI13_RS18245	4029666..4029932	+	267	WP_121546811.1	CopG family transcriptional regulator	-
LLI13_RS18250	4029929..4030372	+	444	WP_121546812.1	PIN domain-containing protein	-
LLI13_RS18255	4030981..4031808	+	828	WP_228313141.1	DUF2182 domain-containing protein	-
LLI13_RS18260	4031895..4032551	-	657	WP_121546813.1	DUF1326 domain-containing protein	-
LLI13_RS18265	4033065..4033220	+	156	WP_228313001.1	hypothetical protein	-
LLI13_RS18270	4033566..4033787	+	222	WP_004928730.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
LLI13_RS18275	4033784..4034194	+	411	WP_121546814.1	PIN domain-containing protein	Toxin
LLI13_RS18280	4034228..4034504	+	277	Protein_3592	integrase	-
LLI13_RS18285	4035277..4035640	+	364	Protein_3593	pyridine nucleotide-disulfide oxidoreductase	-
LLI13_RS18290	4035951..4036484	+	534	WP_121546815.1	DUF5994 family protein	-
LLI13_RS18295	4036452..4036847	-	396	WP_203550461.1	DUF5994 family protein	-
LLI13_RS18300	4037163..4037753	+	591	WP_033276641.1	DUF5994 family protein	-
LLI13_RS18305	4037759..4038040	+	282	WP_033276642.1	hypothetical protein	-
LLI13_RS18310	4038037..4039077	-	1041	WP_121546816.1	acyl-CoA desaturase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-121)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (3-42)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 15031.82 Da
• Isoelectric Point: 6.2112

>T222652 WP_121546814.1 NZ_CP086179:4033784-4034194 [Streptomyces fungicidicus]
VIYLLDTSGLVRLLRDPKLQSAWYDAIDAGAIASCYVQRAEFLHSARNGREYDEITEMFTDLYPDVSVPKNAGRWIGAVQ
HRMARAGEHRSASAVDLLIAATAAHHGLAVLHDDADYRAIARHASDLTEHNVHDIA

Nucleotide

• Length: 411 bp

>T222652 NZ_CP117988:c1555806-1555309 [Vibrio campbellii]
ATGATGAATACGGTACTTCTAGATAAAGCTAAACACGATAGAAACCGATTCAACTGTGGTATCGAAGCTCTCAATAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCAAAAAAAGACAACACCAGAACATTTGTTTTGGAAGATGATAACGACAACTCAC
ATGTCATCGGCTTTTACACGCTAACAATGACACCAATTGACTTAAAGGCATTGCCCGATAAGTTACAAAAAAAACACCAA
TCATCCACCTCTGGTGGTCTGATTGCCCGCCTTGCTGTCGATGACCGATACAAAGGGAAAGGCTTTGGTGAGTGGCTGCT
TATTGACGCACTCAGAAAGCTATTAGCTGCAAGTGATAGCGTTGCATTTCCAGTTGTTATCGTTGATGCCAAAGACGGTG
CGAAACACTTCTATGAACGCTATGGTTTTCAAGCATTTGAAGACGCTGAAAATAAACTCTTCATCACCATTGCTGATGTG
AGAGCAAGCTTAGGCTAG

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8561.59 Da
• Isoelectric Point: 7.3209

>AT222652 WP_004928730.1 NZ_CP086179:4033566-4033787 [Streptomyces fungicidicus]
MSVTQIDIDDDALERAMALAHVRTKKEAVNLALNFYAEQQERAARISRHFERAREWGAVEDAERLHRAEKRNR

Nucleotide

• Length: 222 bp

>AT222652 NZ_CP117988:c1556075-1555803 [Vibrio campbellii]
ATGGCTACTACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACACAAGACTTACTTACTAAGGCTGCCGCGATCGC
CGGTATGTCTAGCATCAACTCGTTCGTTCTAAGCGCTGCAATCGAAAAAGCTAAACAAGTCATCGAACGTGAACAGGCTT
TAAAACTGAGCCAAGCAGATGCGATGTTGCTCATGGAAGCTTTAGACCGTCCTGCAACACAGAACTCAAAACTAAAAGCT
GCTGCTGATCGATACGAGAGCAAAATTCAATGA

Structures

Antitoxin

• AlphaFold DB: D9XL36