Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 4034003..4034631 Replicon chromosome
Accession NZ_CP086177
Organism Streptomyces fungicidicus strain F7

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LL040_RS18275 Protein ID WP_121546814.1
Coordinates 4034221..4034631 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID D9XL36
Locus tag LL040_RS18270 Protein ID WP_004928730.1
Coordinates 4034003..4034224 (+) Length 74 a.a.

Genomic Context

LL040_RS18245LL040_RS18250LL040_RS18255LL040_RS18265LL040_RS18270LL040_RS18275LL040_RS18280LL040_RS18285LL040_RS18290LL040_RS18300LL040_RS18305LL040_RS18260LL040_RS18295LL040_RS18310
Location: 4030103..4030369 (267 bp)
Type: Others
Protein ID: WP_121546811.1
Location: 4030366..4030809 (444 bp)
Type: Others
Protein ID: WP_121546812.1
Location: 4031418..4032245 (828 bp)
Type: Others
Protein ID: WP_228313141.1
Location: 4033502..4033657 (156 bp)
Type: Others
Protein ID: WP_228313001.1
Location: 4034003..4034224 (222 bp)
Type: Antitoxin
Protein ID: WP_004928730.1
Location: 4034221..4034631 (411 bp)
Type: Toxin
Protein ID: WP_121546814.1
Location: 4034665..4034941 (277 bp)
Type: Others
Protein ID: Protein_3594
Location: 4035714..4036077 (364 bp)
Type: Others
Protein ID: Protein_3595
Location: 4036388..4036921 (534 bp)
Type: Others
Protein ID: WP_121546815.1
Location: 4037600..4038190 (591 bp)
Type: Others
Protein ID: WP_033276641.1
Location: 4038196..4038477 (282 bp)
Type: Others
Protein ID: WP_033276642.1
Location: 4032332..4032988 (657 bp)
Type: Others
Protein ID: WP_121546813.1
Location: 4036889..4037284 (396 bp)
Type: Others
Protein ID: WP_203550461.1
Location: 4038474..4039514 (1041 bp)
Type: Others
Protein ID: WP_121546816.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
LL040_RS182454030103..4030369+267WP_121546811.1CopG family transcriptional regulator-
LL040_RS182504030366..4030809+444WP_121546812.1PIN domain-containing protein-
LL040_RS182554031418..4032245+828WP_228313141.1DUF2182 domain-containing protein-
LL040_RS182604032332..4032988-657WP_121546813.1DUF1326 domain-containing protein-
LL040_RS182654033502..4033657+156WP_228313001.1hypothetical protein-
LL040_RS182704034003..4034224+222WP_004928730.1type II toxin-antitoxin system VapB family antitoxinAntitoxin
LL040_RS182754034221..4034631+411WP_121546814.1PIN domain-containing proteinToxin
LL040_RS182804034665..4034941+277Protein_3594integrase-
LL040_RS182854035714..4036077+364Protein_3595pyridine nucleotide-disulfide oxidoreductase-
LL040_RS182904036388..4036921+534WP_121546815.1DUF5994 family protein-
LL040_RS182954036889..4037284-396WP_203550461.1DUF5994 family protein-
LL040_RS183004037600..4038190+591WP_033276641.1DUF5994 family protein-
LL040_RS183054038196..4038477+282WP_033276642.1hypothetical protein-
LL040_RS183104038474..4039514-1041WP_121546816.1acyl-CoA desaturase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-121)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(3-42)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15031.82 Da        Isoelectric Point: 6.2112

>T222644 WP_121546814.1 NZ_CP086177:4034221-4034631 [Streptomyces fungicidicus]
VIYLLDTSGLVRLLRDPKLQSAWYDAIDAGAIASCYVQRAEFLHSARNGREYDEITEMFTDLYPDVSVPKNAGRWIGAVQ
HRMARAGEHRSASAVDLLIAATAAHHGLAVLHDDADYRAIARHASDLTEHNVHDIA

Download         Length: 411 bp

>T222644 NZ_CP117979:c2432885-2432523 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8561.59 Da        Isoelectric Point: 7.3209

>AT222644 WP_004928730.1 NZ_CP086177:4034003-4034224 [Streptomyces fungicidicus]
MSVTQIDIDDDALERAMALAHVRTKKEAVNLALNFYAEQQERAARISRHFERAREWGAVEDAERLHRAEKRNR

Download         Length: 222 bp

>AT222644 NZ_CP117979:c2433052-2432882 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBD9XL36

References