Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 3241953..3242478 Replicon chromosome
Accession NZ_CP086177
Organism Streptomyces fungicidicus strain F7

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag LL040_RS14440 Protein ID WP_121546319.1
Coordinates 3242212..3242478 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A7H8J816
Locus tag LL040_RS14435 Protein ID WP_040908670.1
Coordinates 3241953..3242219 (+) Length 89 a.a.

Genomic Context

LL040_RS14405LL040_RS14410LL040_RS14415LL040_RS14420LL040_RS14435LL040_RS14440LL040_RS14425LL040_RS14430LL040_RS14445LL040_RS14450
Location: 3237417..3238178 (762 bp)
Type: Others
Protein ID: WP_121546315.1
Location: 3238166..3238936 (771 bp)
Type: Others
Protein ID: WP_121546316.1
Location: 3238948..3239418 (471 bp)
Type: Others
Protein ID: WP_004930328.1
Location: 3239476..3240696 (1221 bp)
Type: Others
Protein ID: WP_121546317.1
Location: 3241953..3242219 (267 bp)
Type: Antitoxin
Protein ID: WP_040908670.1
Location: 3242212..3242478 (267 bp)
Type: Toxin
Protein ID: WP_121546319.1
Location: 3240697..3240972 (276 bp)
Type: Others
Protein ID: WP_121546318.1
Location: 3241053..3241898 (846 bp)
Type: Others
Protein ID: WP_004930321.1
Location: 3242585..3244792 (2208 bp)
Type: Others
Protein ID: WP_121546320.1
Location: 3244893..3245492 (600 bp)
Type: Others
Protein ID: WP_004930314.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
LL040_RS144053237417..3238178+762WP_121546315.1cobalt ECF transporter T component CbiQ-
LL040_RS144103238166..3238936+771WP_121546316.1ABC transporter ATP-binding protein-
LL040_RS144153238948..3239418+471WP_004930328.1MarR family transcriptional regulator-
LL040_RS144203239476..3240696+1221WP_121546317.1serine hydrolase domain-containing protein-
LL040_RS144253240697..3240972-276WP_121546318.1DUF1876 domain-containing protein-
LL040_RS144303241053..3241898-846WP_004930321.1DMT family transporter-
LL040_RS144353241953..3242219+267WP_040908670.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
LL040_RS144403242212..3242478+267WP_121546319.1type II toxin-antitoxin system RelE/ParE family toxinToxin
LL040_RS144453242585..3244792-2208WP_121546320.1MMPL family transporter-
LL040_RS144503244893..3245492-600WP_004930314.1TetR/AcrR family transcriptional regulator-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(9-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(6-57)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10199.72 Da        Isoelectric Point: 10.2960

>T222642 WP_121546319.1 NZ_CP086177:3242212-3242478 [Streptomyces fungicidicus]
VSSGYRTVFRPEAQAELRKIPRDMALRILVKLTELETDPLGFRTTALVSRPDRRRLRVGDYRVIYTIDNGELTVWVVHVG
HRSTVYDT

Download         Length: 267 bp

>T222642 NZ_CP117979:c1236297-1236109 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10218.61 Da        Isoelectric Point: 4.5329

>AT222642 WP_040908670.1 NZ_CP086177:3241953-3242219 [Streptomyces fungicidicus]
MTEMPIESIRDVRAHLAEVVERADRDDTPTVITRRGKQVAAVVSMEVLRKYQEWEEREINRIIDERMANPAAGIPIEDVM
RETLERGE

Download         Length: 267 bp

>AT222642 NZ_CP117979:c1236586-1236326 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTATATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A7H8J816

References