Detailed information of TA system TA222642

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 3241953..3242478
• Replicon: chromosome
• Accession: NZ_CP086177
• Organism: Streptomyces fungicidicus strain F7

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LL040_RS14440
• Protein ID: WP_121546319.1
• Coordinates: 3242212..3242478 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A7H8J816
• Locus tag: LL040_RS14435
• Protein ID: WP_040908670.1
• Coordinates: 3241953..3242219 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LL040_RS14405	3237417..3238178	+	762	WP_121546315.1	cobalt ECF transporter T component CbiQ	-
LL040_RS14410	3238166..3238936	+	771	WP_121546316.1	ABC transporter ATP-binding protein	-
LL040_RS14415	3238948..3239418	+	471	WP_004930328.1	MarR family transcriptional regulator	-
LL040_RS14420	3239476..3240696	+	1221	WP_121546317.1	serine hydrolase domain-containing protein	-
LL040_RS14425	3240697..3240972	-	276	WP_121546318.1	DUF1876 domain-containing protein	-
LL040_RS14430	3241053..3241898	-	846	WP_004930321.1	DMT family transporter	-
LL040_RS14435	3241953..3242219	+	267	WP_040908670.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
LL040_RS14440	3242212..3242478	+	267	WP_121546319.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LL040_RS14445	3242585..3244792	-	2208	WP_121546320.1	MMPL family transporter	-
LL040_RS14450	3244893..3245492	-	600	WP_004930314.1	TetR/AcrR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (9-86)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (6-57)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10199.72 Da
• Isoelectric Point: 10.2960

>T222642 WP_121546319.1 NZ_CP086177:3242212-3242478 [Streptomyces fungicidicus]
VSSGYRTVFRPEAQAELRKIPRDMALRILVKLTELETDPLGFRTTALVSRPDRRRLRVGDYRVIYTIDNGELTVWVVHVG
HRSTVYDT

Nucleotide

• Length: 267 bp

>T222642 NZ_CP117979:c1236297-1236109 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10218.61 Da
• Isoelectric Point: 4.5329

>AT222642 WP_040908670.1 NZ_CP086177:3241953-3242219 [Streptomyces fungicidicus]
MTEMPIESIRDVRAHLAEVVERADRDDTPTVITRRGKQVAAVVSMEVLRKYQEWEEREINRIIDERMANPAAGIPIEDVM
RETLERGE

Nucleotide

• Length: 267 bp

>AT222642 NZ_CP117979:c1236586-1236326 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTATATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Structures

Antitoxin

• AlphaFold DB: A0A7H8J816