Detailed information of TA system TA222641

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/Fic(toxin)
• Location: 2966147..2966712
• Replicon: chromosome
• Accession: NZ_CP086177
• Organism: Streptomyces fungicidicus strain F7

Toxin (Protein)

• Gene name: doc
• Uniprot ID: -
• Locus tag: LL040_RS13300
• Protein ID: WP_121546168.1
• Coordinates: 2966147..2966515 (-)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: -
• Locus tag: LL040_RS13305
• Protein ID: WP_121546169.1
• Coordinates: 2966515..2966712 (-)
• Length: 66 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LL040_RS13280	2961223..2962200	+	978	WP_121546166.1	glycine betaine ABC transporter substrate-binding protein	-
LL040_RS13285	2962197..2962988	-	792	WP_121546167.1	S16 family serine protease	-
LL040_RS13290	2963297..2963938	-	642	WP_040907076.1	helix-turn-helix domain-containing protein	-
LL040_RS13295	2964223..2966022	-	1800	WP_004930870.1	DEAD/DEAH box helicase	-
LL040_RS13300	2966147..2966515	-	369	WP_121546168.1	Fic family protein	Toxin
LL040_RS13305	2966515..2966712	-	198	WP_121546169.1	hypothetical protein	Antitoxin
LL040_RS13310	2966745..2968205	-	1461	WP_121546170.1	MFS transporter	-
LL040_RS13320	2968547..2969770	+	1224	WP_228312966.1	hypothetical protein	-
LL040_RS13325	2969787..2970965	-	1179	WP_121546172.1	SUKH-4 family immunity protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Fido domain (4-80)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13745.67 Da
• Isoelectric Point: 4.6413

>T222641 WP_121546168.1 NZ_CP086177:c2966515-2966147 [Streptomyces fungicidicus]
MYYLTLPELLNLAKRLGEDVVRDYGLLDSALARPQSSVFGQDAYPDVWQKAAALMESLARNHALVDGNKRLAWYATWVFL
HMNGHPLDPDFDVDEAEQFVLDVCQGALDVPKIAAQLPRFAR

Nucleotide

• Length: 369 bp

>T222641 NZ_CP117979:c107227-106961 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCGGCGAAGTTAGATTTAAAGAAAATAAAACATCCTTATTTAAAGAAGAC
ATTTATAGAAATTGTTGAGACTTTAAAAAAAAATCCTTATAAAATAACACAATCCTTTGAAAAATTAGAACCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCTTCAGCACAGGGTCGTCTATACCATAGATGATCGAAATAAAGTAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin

Protein

• Length: 66 a.a.
• Molecular weight: 7349.21 Da
• Isoelectric Point: 5.5900

>AT222641 WP_121546169.1 NZ_CP086177:c2966712-2966515 [Streptomyces fungicidicus]
MAGLNLRFTDEELDALRERAAAEGRSMQTFAHDAVIKAINEHSRLFNEAADHVLRASEELNRRLA

Nucleotide

• Length: 198 bp

>AT222641 NZ_CP117979:c107484-107227 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGTAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATGT
ATCTTGTATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA