Detailed information of TA system TA222640

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 4033996..4034624
• Replicon: chromosome
• Accession: NZ_CP086176
• Organism: Streptomyces fungicidicus strain F8

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: LL041_RS18280
• Protein ID: WP_121546814.1
• Coordinates: 4034214..4034624 (+)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: D9XL36
• Locus tag: LL041_RS18275
• Protein ID: WP_004928730.1
• Coordinates: 4033996..4034217 (+)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LL041_RS18250	4030096..4030362	+	267	WP_121546811.1	CopG family transcriptional regulator	-
LL041_RS18255	4030359..4030802	+	444	WP_121546812.1	PIN domain-containing protein	-
LL041_RS18260	4031411..4032238	+	828	WP_228313141.1	DUF2182 domain-containing protein	-
LL041_RS18265	4032325..4032981	-	657	WP_121546813.1	DUF1326 domain-containing protein	-
LL041_RS18270	4033495..4033650	+	156	WP_228313001.1	hypothetical protein	-
LL041_RS18275	4033996..4034217	+	222	WP_004928730.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
LL041_RS18280	4034214..4034624	+	411	WP_121546814.1	PIN domain-containing protein	Toxin
LL041_RS18285	4034658..4034934	+	277	Protein_3593	integrase	-
LL041_RS18290	4035707..4036070	+	364	Protein_3594	pyridine nucleotide-disulfide oxidoreductase	-
LL041_RS18295	4036381..4036914	+	534	WP_121546815.1	DUF5994 family protein	-
LL041_RS18300	4036882..4037277	-	396	WP_203550461.1	DUF5994 family protein	-
LL041_RS18305	4037593..4038183	+	591	WP_033276641.1	DUF5994 family protein	-
LL041_RS18310	4038189..4038470	+	282	WP_033276642.1	hypothetical protein	-
LL041_RS18315	4038467..4039507	-	1041	WP_121546816.1	acyl-CoA desaturase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-121)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (3-42)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 15031.82 Da
• Isoelectric Point: 6.2112

>T222640 WP_121546814.1 NZ_CP086176:4034214-4034624 [Streptomyces fungicidicus]
VIYLLDTSGLVRLLRDPKLQSAWYDAIDAGAIASCYVQRAEFLHSARNGREYDEITEMFTDLYPDVSVPKNAGRWIGAVQ
HRMARAGEHRSASAVDLLIAATAAHHGLAVLHDDADYRAIARHASDLTEHNVHDIA

Nucleotide

• Length: 411 bp

>T222640 NZ_CP117979:c50330-50064 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8561.59 Da
• Isoelectric Point: 7.3209

>AT222640 WP_004928730.1 NZ_CP086176:4033996-4034217 [Streptomyces fungicidicus]
MSVTQIDIDDDALERAMALAHVRTKKEAVNLALNFYAEQQERAARISRHFERAREWGAVEDAERLHRAEKRNR

Nucleotide

• Length: 222 bp

>AT222640 NZ_CP117979:c50581-50330 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Structures

Antitoxin

• AlphaFold DB: D9XL36