Detailed information of TA system TA222638

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 3241946..3242471
• Replicon: chromosome
• Accession: NZ_CP086176
• Organism: Streptomyces fungicidicus strain F8

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LL041_RS14445
• Protein ID: WP_121546319.1
• Coordinates: 3242205..3242471 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A7H8J816
• Locus tag: LL041_RS14440
• Protein ID: WP_040908670.1
• Coordinates: 3241946..3242212 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LL041_RS14410	3237410..3238171	+	762	WP_121546315.1	cobalt ECF transporter T component CbiQ	-
LL041_RS14415	3238159..3238929	+	771	WP_121546316.1	ABC transporter ATP-binding protein	-
LL041_RS14420	3238941..3239411	+	471	WP_004930328.1	MarR family transcriptional regulator	-
LL041_RS14425	3239469..3240689	+	1221	WP_121546317.1	serine hydrolase domain-containing protein	-
LL041_RS14430	3240690..3240965	-	276	WP_121546318.1	DUF1876 domain-containing protein	-
LL041_RS14435	3241046..3241891	-	846	WP_004930321.1	DMT family transporter	-
LL041_RS14440	3241946..3242212	+	267	WP_040908670.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
LL041_RS14445	3242205..3242471	+	267	WP_121546319.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LL041_RS14450	3242578..3244785	-	2208	WP_121546320.1	MMPL family transporter	-
LL041_RS14455	3244886..3245485	-	600	WP_004930314.1	TetR/AcrR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (9-86)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (6-57)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10199.72 Da
• Isoelectric Point: 10.2960

>T222638 WP_121546319.1 NZ_CP086176:3242205-3242471 [Streptomyces fungicidicus]
VSSGYRTVFRPEAQAELRKIPRDMALRILVKLTELETDPLGFRTTALVSRPDRRRLRVGDYRVIYTIDNGELTVWVVHVG
HRSTVYDT

Nucleotide

• Length: 267 bp

>T222638 NZ_CP117977:12942-13340 [Salmonella enterica]
ATGCTGAAGTTTATGCTGGATACTAACATCTGCATTTTCACGATAAAAAACAAACCTGCCAGCGTCAGGGAGCGTTTTAA
CCTGAACCAGGGGAGAATGTGTATCAGCTCGGTCACCCTGATGGAGCTGATTTACGGTGCCGAAAAAAGCCAGATGCCCG
AAAGAAATCTCGCTGTGATAGAGGGGTTTGTTTCCCGACTTGATGTTCTGGATTATGACACGCCGGCCGCCACCCATACG
GGGCAGATCAGGGCAGAGCTTGCCCGTCAGGGACGCCCTGTCGGGCCATTCGATCAGATGATTGCCGGTCACGCACGCAG
CCGGGGACTGATTGTTGTCACGAACAACACCCGGGAGTTTGAACGTGTGGGTGGACTGAGAACTGAGGACTGGAGCTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10218.61 Da
• Isoelectric Point: 4.5329

>AT222638 WP_040908670.1 NZ_CP086176:3241946-3242212 [Streptomyces fungicidicus]
MTEMPIESIRDVRAHLAEVVERADRDDTPTVITRRGKQVAAVVSMEVLRKYQEWEEREINRIIDERMANPAAGIPIEDVM
RETLERGE

Nucleotide

• Length: 267 bp

>AT222638 NZ_CP117977:12715-12942 [Salmonella enterica]
ATGGAAACCAGCGTATTTCTCAGTAACCGAAGTCAGGCGGTCAGACTGCCAAAAGCAGTGGCATTGCCGGAACATGTAAA
ACGTGTGGAAGTTATCGCTGTCGGGCGAACCCGGATCATCACGCCGGCCGGAGAATCGTGGGATGAATGGTTCGACGGGA
ACAACGTCAGCGCCGATTTTATGGATAACCGGGAACAACCCTCTGTGCAGGAACGGGAATCATTCTGA

Structures

Antitoxin

• AlphaFold DB: A0A7H8J816