Detailed information of TA system TA222636

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 4033570..4034198
• Replicon: chromosome
• Accession: NZ_CP086175
• Organism: Streptomyces fungicidicus strain F9

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: LL042_RS18275
• Protein ID: WP_121546814.1
• Coordinates: 4033788..4034198 (+)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: D9XL36
• Locus tag: LL042_RS18270
• Protein ID: WP_004928730.1
• Coordinates: 4033570..4033791 (+)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LL042_RS18245	4029670..4029936	+	267	WP_121546811.1	CopG family transcriptional regulator	-
LL042_RS18250	4029933..4030376	+	444	WP_121546812.1	PIN domain-containing protein	-
LL042_RS18255	4030985..4031812	+	828	WP_228313141.1	DUF2182 domain-containing protein	-
LL042_RS18260	4031899..4032555	-	657	WP_121546813.1	DUF1326 domain-containing protein	-
LL042_RS18265	4033069..4033224	+	156	WP_228313001.1	hypothetical protein	-
LL042_RS18270	4033570..4033791	+	222	WP_004928730.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
LL042_RS18275	4033788..4034198	+	411	WP_121546814.1	PIN domain-containing protein	Toxin
LL042_RS18280	4034232..4034508	+	277	Protein_3592	integrase	-
LL042_RS18285	4035281..4035644	+	364	Protein_3593	pyridine nucleotide-disulfide oxidoreductase	-
LL042_RS18290	4035955..4036488	+	534	WP_121546815.1	DUF5994 family protein	-
LL042_RS18295	4036456..4036851	-	396	WP_203550461.1	DUF5994 family protein	-
LL042_RS18300	4037167..4037757	+	591	WP_033276641.1	DUF5994 family protein	-
LL042_RS18305	4037763..4038044	+	282	WP_033276642.1	hypothetical protein	-
LL042_RS18310	4038041..4039081	-	1041	WP_121546816.1	acyl-CoA desaturase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-121)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (3-42)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 15031.82 Da
• Isoelectric Point: 6.2112

>T222636 WP_121546814.1 NZ_CP086175:4033788-4034198 [Streptomyces fungicidicus]
VIYLLDTSGLVRLLRDPKLQSAWYDAIDAGAIASCYVQRAEFLHSARNGREYDEITEMFTDLYPDVSVPKNAGRWIGAVQ
HRMARAGEHRSASAVDLLIAATAAHHGLAVLHDDADYRAIARHASDLTEHNVHDIA

Nucleotide

• Length: 411 bp

>T222636 NZ_CP117976:c4351200-4350802 [Salmonella enterica]
ATGCTGAAATTCATGCTTGATACCAATACCTGTATTTTCACCATCAAAAATAAGCCCGAACACATCAGAGAACGCTTCAA
CCTCAATACATCCCGAATGTGTATCAGCTCCATCACCTTAATGGAGCTGATTTACGGTGCTGAAAAAAGCCTGGCGCCGG
AGCGTAATCTTGCCGTCGTGGAGGGATTTATCTCCCGCCTTGAGGTTCTGGATTACGATACACAGGCAGCGATACATACC
GGTCAAATCCGTGCCGAACTGGCCCGCAAGGGAACACCTGTCGGGCCTTATGACCAGATGATTGCTGGCCATGCCCGTAG
CCGCGGACTGGTCGTCGTCACAAACAATCTCCGCGAGTTTGAACGCATTCCGGGTATCCGAATCGAAGACTGGTGCTAA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8561.59 Da
• Isoelectric Point: 7.3209

>AT222636 WP_004928730.1 NZ_CP086175:4033570-4033791 [Streptomyces fungicidicus]
MSVTQIDIDDDALERAMALAHVRTKKEAVNLALNFYAEQQERAARISRHFERAREWGAVEDAERLHRAEKRNR

Nucleotide

• Length: 222 bp

>AT222636 NZ_CP117976:c4351427-4351200 [Salmonella enterica]
ATGCACACAACACTTTTTTTTAGTAACCGGACCCAGGCAGTCAGATTGCCTAAATCGATATCCTTTCCGGATGATGTGAA
ACATGTCGAAATCATTGCGGTTGGCAGAAGCAGAATCATTACTCCAGTCGGAGAATCCTGGGACAGCTGGTTCGATGGCG
AAGGCGCCAGTACTGATTTTATGAGTACCAGAGAACAACCCGCAGTACAGGAACGGGAAGGATTCTGA

Structures

Antitoxin

• AlphaFold DB: D9XL36