Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 3241520..3242045 Replicon chromosome
Accession NZ_CP086175
Organism Streptomyces fungicidicus strain F9

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag LL042_RS14440 Protein ID WP_121546319.1
Coordinates 3241779..3242045 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A7H8J816
Locus tag LL042_RS14435 Protein ID WP_040908670.1
Coordinates 3241520..3241786 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LL042_RS14405 3236984..3237745 + 762 WP_121546315.1 cobalt ECF transporter T component CbiQ -
LL042_RS14410 3237733..3238503 + 771 WP_121546316.1 ABC transporter ATP-binding protein -
LL042_RS14415 3238515..3238985 + 471 WP_004930328.1 MarR family transcriptional regulator -
LL042_RS14420 3239043..3240263 + 1221 WP_121546317.1 serine hydrolase domain-containing protein -
LL042_RS14425 3240264..3240539 - 276 WP_121546318.1 DUF1876 domain-containing protein -
LL042_RS14430 3240620..3241465 - 846 WP_004930321.1 DMT family transporter -
LL042_RS14435 3241520..3241786 + 267 WP_040908670.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LL042_RS14440 3241779..3242045 + 267 WP_121546319.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LL042_RS14445 3242152..3244359 - 2208 WP_121546320.1 MMPL family transporter -
LL042_RS14450 3244460..3245059 - 600 WP_004930314.1 TetR/AcrR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(9-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(6-57)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10199.72 Da        Isoelectric Point: 10.2960

>T222634 WP_121546319.1 NZ_CP086175:3241779-3242045 [Streptomyces fungicidicus]
VSSGYRTVFRPEAQAELRKIPRDMALRILVKLTELETDPLGFRTTALVSRPDRRRLRVGDYRVIYTIDNGELTVWVVHVG
HRSTVYDT

Download         Length: 267 bp

>T222634 NZ_CP117976:c3191309-3191206 [Salmonella enterica]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10218.61 Da        Isoelectric Point: 4.5329

>AT222634 WP_040908670.1 NZ_CP086175:3241520-3241786 [Streptomyces fungicidicus]
MTEMPIESIRDVRAHLAEVVERADRDDTPTVITRRGKQVAAVVSMEVLRKYQEWEEREINRIIDERMANPAAGIPIEDVM
RETLERGE

Download         Length: 267 bp

>AT222634 NZ_CP117976:3191204-3191347 [Salmonella enterica]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7H8J816

References