Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RelE-Phd |
| Location | 3241520..3242045 | Replicon | chromosome |
| Accession | NZ_CP086175 | ||
| Organism | Streptomyces fungicidicus strain F9 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | - |
| Locus tag | LL042_RS14440 | Protein ID | WP_121546319.1 |
| Coordinates | 3241779..3242045 (+) | Length | 89 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | A0A7H8J816 |
| Locus tag | LL042_RS14435 | Protein ID | WP_040908670.1 |
| Coordinates | 3241520..3241786 (+) | Length | 89 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LL042_RS14405 | 3236984..3237745 | + | 762 | WP_121546315.1 | cobalt ECF transporter T component CbiQ | - |
| LL042_RS14410 | 3237733..3238503 | + | 771 | WP_121546316.1 | ABC transporter ATP-binding protein | - |
| LL042_RS14415 | 3238515..3238985 | + | 471 | WP_004930328.1 | MarR family transcriptional regulator | - |
| LL042_RS14420 | 3239043..3240263 | + | 1221 | WP_121546317.1 | serine hydrolase domain-containing protein | - |
| LL042_RS14425 | 3240264..3240539 | - | 276 | WP_121546318.1 | DUF1876 domain-containing protein | - |
| LL042_RS14430 | 3240620..3241465 | - | 846 | WP_004930321.1 | DMT family transporter | - |
| LL042_RS14435 | 3241520..3241786 | + | 267 | WP_040908670.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| LL042_RS14440 | 3241779..3242045 | + | 267 | WP_121546319.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| LL042_RS14445 | 3242152..3244359 | - | 2208 | WP_121546320.1 | MMPL family transporter | - |
| LL042_RS14450 | 3244460..3245059 | - | 600 | WP_004930314.1 | TetR/AcrR family transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10199.72 Da Isoelectric Point: 10.2960
>T222634 WP_121546319.1 NZ_CP086175:3241779-3242045 [Streptomyces fungicidicus]
VSSGYRTVFRPEAQAELRKIPRDMALRILVKLTELETDPLGFRTTALVSRPDRRRLRVGDYRVIYTIDNGELTVWVVHVG
HRSTVYDT
VSSGYRTVFRPEAQAELRKIPRDMALRILVKLTELETDPLGFRTTALVSRPDRRRLRVGDYRVIYTIDNGELTVWVVHVG
HRSTVYDT
Download Length: 267 bp
>T222634 NZ_CP117976:c3191309-3191206 [Salmonella enterica]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT
Antitoxin
Download Length: 89 a.a. Molecular weight: 10218.61 Da Isoelectric Point: 4.5329
>AT222634 WP_040908670.1 NZ_CP086175:3241520-3241786 [Streptomyces fungicidicus]
MTEMPIESIRDVRAHLAEVVERADRDDTPTVITRRGKQVAAVVSMEVLRKYQEWEEREINRIIDERMANPAAGIPIEDVM
RETLERGE
MTEMPIESIRDVRAHLAEVVERADRDDTPTVITRRGKQVAAVVSMEVLRKYQEWEEREINRIIDERMANPAAGIPIEDVM
RETLERGE
Download Length: 267 bp
>AT222634 NZ_CP117976:3191204-3191347 [Salmonella enterica]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTG
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|