Detailed information of TA system TA222630

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 3241518..3242043
• Replicon: chromosome
• Accession: NZ_CP086174
• Organism: Streptomyces fungicidicus strain F10

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LL043_RS14440
• Protein ID: WP_121546319.1
• Coordinates: 3241777..3242043 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A7H8J816
• Locus tag: LL043_RS14435
• Protein ID: WP_040908670.1
• Coordinates: 3241518..3241784 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LL043_RS14405	3236982..3237743	+	762	WP_121546315.1	cobalt ECF transporter T component CbiQ	-
LL043_RS14410	3237731..3238501	+	771	WP_121546316.1	ABC transporter ATP-binding protein	-
LL043_RS14415	3238513..3238983	+	471	WP_004930328.1	MarR family transcriptional regulator	-
LL043_RS14420	3239041..3240261	+	1221	WP_121546317.1	serine hydrolase domain-containing protein	-
LL043_RS14425	3240262..3240537	-	276	WP_121546318.1	DUF1876 domain-containing protein	-
LL043_RS14430	3240618..3241463	-	846	WP_004930321.1	DMT family transporter	-
LL043_RS14435	3241518..3241784	+	267	WP_040908670.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
LL043_RS14440	3241777..3242043	+	267	WP_121546319.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LL043_RS14445	3242150..3244357	-	2208	WP_121546320.1	MMPL family transporter	-
LL043_RS14450	3244458..3245057	-	600	WP_004930314.1	TetR/AcrR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (9-86)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (6-57)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10199.72 Da
• Isoelectric Point: 10.2960

>T222630 WP_121546319.1 NZ_CP086174:3241777-3242043 [Streptomyces fungicidicus]
VSSGYRTVFRPEAQAELRKIPRDMALRILVKLTELETDPLGFRTTALVSRPDRRRLRVGDYRVIYTIDNGELTVWVVHVG
HRSTVYDT

Nucleotide

• Length: 267 bp

>T222630 NZ_CP117976:1010823-1011107 [Salmonella enterica]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGAAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGGTCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGTCTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTCGCGGTCGGCAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10218.61 Da
• Isoelectric Point: 4.5329

>AT222630 WP_040908670.1 NZ_CP086174:3241518-3241784 [Streptomyces fungicidicus]
MTEMPIESIRDVRAHLAEVVERADRDDTPTVITRRGKQVAAVVSMEVLRKYQEWEEREINRIIDERMANPAAGIPIEDVM
RETLERGE

Nucleotide

• Length: 267 bp

>AT222630 NZ_CP117976:1010591-1010833 [Salmonella enterica]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAAGATGCATTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Structures

Antitoxin

• AlphaFold DB: A0A7H8J816