Detailed information of TA system TA222628

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 4033568..4034196
• Replicon: chromosome
• Accession: NZ_CP086173
• Organism: Streptomyces fungicidicus strain ATCC 21013

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: LL044_RS18275
• Protein ID: WP_121546814.1
• Coordinates: 4033786..4034196 (+)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: D9XL36
• Locus tag: LL044_RS18270
• Protein ID: WP_004928730.1
• Coordinates: 4033568..4033789 (+)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LL044_RS18245	4029668..4029934	+	267	WP_121546811.1	CopG family transcriptional regulator	-
LL044_RS18250	4029931..4030374	+	444	WP_121546812.1	PIN domain-containing protein	-
LL044_RS18255	4030983..4031810	+	828	WP_228313141.1	DUF2182 domain-containing protein	-
LL044_RS18260	4031897..4032553	-	657	WP_121546813.1	DUF1326 domain-containing protein	-
LL044_RS18265	4033067..4033222	+	156	WP_228313001.1	hypothetical protein	-
LL044_RS18270	4033568..4033789	+	222	WP_004928730.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
LL044_RS18275	4033786..4034196	+	411	WP_121546814.1	PIN domain-containing protein	Toxin
LL044_RS18280	4034230..4034506	+	277	Protein_3592	integrase	-
LL044_RS18285	4035279..4035642	+	364	Protein_3593	pyridine nucleotide-disulfide oxidoreductase	-
LL044_RS18290	4035953..4036486	+	534	WP_121546815.1	DUF5994 family protein	-
LL044_RS18295	4036454..4036849	-	396	WP_203550461.1	DUF5994 family protein	-
LL044_RS18300	4037165..4037755	+	591	WP_033276641.1	DUF5994 family protein	-
LL044_RS18305	4037761..4038042	+	282	WP_033276642.1	hypothetical protein	-
LL044_RS18310	4038039..4039079	-	1041	WP_121546816.1	acyl-CoA desaturase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-121)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (3-42)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 15031.82 Da
• Isoelectric Point: 6.2112

>T222628 WP_121546814.1 NZ_CP086173:4033786-4034196 [Streptomyces fungicidicus]
VIYLLDTSGLVRLLRDPKLQSAWYDAIDAGAIASCYVQRAEFLHSARNGREYDEITEMFTDLYPDVSVPKNAGRWIGAVQ
HRMARAGEHRSASAVDLLIAATAAHHGLAVLHDDADYRAIARHASDLTEHNVHDIA

Nucleotide

• Length: 411 bp

>T222628 NZ_CP117976:c197648-197163 [Salmonella enterica]
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTCGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGCGACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGTGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8561.59 Da
• Isoelectric Point: 7.3209

>AT222628 WP_004928730.1 NZ_CP086173:4033568-4033789 [Streptomyces fungicidicus]
MSVTQIDIDDDALERAMALAHVRTKKEAVNLALNFYAEQQERAARISRHFERAREWGAVEDAERLHRAEKRNR

Nucleotide

• Length: 222 bp

>AT222628 NZ_CP117976:c197923-197636 [Salmonella enterica]
ATGCTATACAAAGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCAGGCAGCCGAGAAAGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATCAATCTGCTTGATGCACCGGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTGTAA

Structures

Antitoxin

• AlphaFold DB: D9XL36