Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 4033568..4034196 Replicon chromosome
Accession NZ_CP086173
Organism Streptomyces fungicidicus strain ATCC 21013

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LL044_RS18275 Protein ID WP_121546814.1
Coordinates 4033786..4034196 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID D9XL36
Locus tag LL044_RS18270 Protein ID WP_004928730.1
Coordinates 4033568..4033789 (+) Length 74 a.a.

Genomic Context

LL044_RS18245LL044_RS18250LL044_RS18255LL044_RS18265LL044_RS18270LL044_RS18275LL044_RS18280LL044_RS18285LL044_RS18290LL044_RS18300LL044_RS18305LL044_RS18260LL044_RS18295LL044_RS18310
Location: 4029668..4029934 (267 bp)
Type: Others
Protein ID: WP_121546811.1
Location: 4029931..4030374 (444 bp)
Type: Others
Protein ID: WP_121546812.1
Location: 4030983..4031810 (828 bp)
Type: Others
Protein ID: WP_228313141.1
Location: 4033067..4033222 (156 bp)
Type: Others
Protein ID: WP_228313001.1
Location: 4033568..4033789 (222 bp)
Type: Antitoxin
Protein ID: WP_004928730.1
Location: 4033786..4034196 (411 bp)
Type: Toxin
Protein ID: WP_121546814.1
Location: 4034230..4034506 (277 bp)
Type: Others
Protein ID: Protein_3592
Location: 4035279..4035642 (364 bp)
Type: Others
Protein ID: Protein_3593
Location: 4035953..4036486 (534 bp)
Type: Others
Protein ID: WP_121546815.1
Location: 4037165..4037755 (591 bp)
Type: Others
Protein ID: WP_033276641.1
Location: 4037761..4038042 (282 bp)
Type: Others
Protein ID: WP_033276642.1
Location: 4031897..4032553 (657 bp)
Type: Others
Protein ID: WP_121546813.1
Location: 4036454..4036849 (396 bp)
Type: Others
Protein ID: WP_203550461.1
Location: 4038039..4039079 (1041 bp)
Type: Others
Protein ID: WP_121546816.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
LL044_RS182454029668..4029934+267WP_121546811.1CopG family transcriptional regulator-
LL044_RS182504029931..4030374+444WP_121546812.1PIN domain-containing protein-
LL044_RS182554030983..4031810+828WP_228313141.1DUF2182 domain-containing protein-
LL044_RS182604031897..4032553-657WP_121546813.1DUF1326 domain-containing protein-
LL044_RS182654033067..4033222+156WP_228313001.1hypothetical protein-
LL044_RS182704033568..4033789+222WP_004928730.1type II toxin-antitoxin system VapB family antitoxinAntitoxin
LL044_RS182754033786..4034196+411WP_121546814.1PIN domain-containing proteinToxin
LL044_RS182804034230..4034506+277Protein_3592integrase-
LL044_RS182854035279..4035642+364Protein_3593pyridine nucleotide-disulfide oxidoreductase-
LL044_RS182904035953..4036486+534WP_121546815.1DUF5994 family protein-
LL044_RS182954036454..4036849-396WP_203550461.1DUF5994 family protein-
LL044_RS183004037165..4037755+591WP_033276641.1DUF5994 family protein-
LL044_RS183054037761..4038042+282WP_033276642.1hypothetical protein-
LL044_RS183104038039..4039079-1041WP_121546816.1acyl-CoA desaturase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-121)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(3-42)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15031.82 Da        Isoelectric Point: 6.2112

>T222628 WP_121546814.1 NZ_CP086173:4033786-4034196 [Streptomyces fungicidicus]
VIYLLDTSGLVRLLRDPKLQSAWYDAIDAGAIASCYVQRAEFLHSARNGREYDEITEMFTDLYPDVSVPKNAGRWIGAVQ
HRMARAGEHRSASAVDLLIAATAAHHGLAVLHDDADYRAIARHASDLTEHNVHDIA

Download         Length: 411 bp

>T222628 NZ_CP117976:c197648-197163 [Salmonella enterica]
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTCGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGCGACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGTGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8561.59 Da        Isoelectric Point: 7.3209

>AT222628 WP_004928730.1 NZ_CP086173:4033568-4033789 [Streptomyces fungicidicus]
MSVTQIDIDDDALERAMALAHVRTKKEAVNLALNFYAEQQERAARISRHFERAREWGAVEDAERLHRAEKRNR

Download         Length: 222 bp

>AT222628 NZ_CP117976:c197923-197636 [Salmonella enterica]
ATGCTATACAAAGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCAGGCAGCCGAGAAAGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATCAATCTGCTTGATGCACCGGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBD9XL36

References